Branched gold-platinum dual-metal nanoparticle as well as preparation method and application thereof

A technology of bimetallic nanoparticles and gold nanoparticles, which is applied in the field of biomedical materials and nanomedicine, can solve the problems of invasiveness and side effects, and achieve good biocompatibility, easy surface modification and functionalization, and high photothermal conversion efficiency Effect

Active Publication Date: 2017-05-31
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at this stage, synergistic therapy mainly focuses on simultaneous radiotherapy and chemotherapy, which has large invasive side effects.

Method used

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  • Branched gold-platinum dual-metal nanoparticle as well as preparation method and application thereof
  • Branched gold-platinum dual-metal nanoparticle as well as preparation method and application thereof
  • Branched gold-platinum dual-metal nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 0.302g of HAuCl 4 4H 2 O and 30ml of oleylamine (OAm) were mixed evenly and added to a 100ml three-necked flask; 2 In an environment accompanied by vigorous magnetic stirring under certain conditions, the mixed solution was heated to 80 °C at a heating rate of 3 °C / min, the solution turned black, and the reaction was maintained at this temperature for 1 hour; after the reaction was completed, the mixed solution was cooled to room temperature, Wash with absolute ethanol and centrifuge to obtain the described gold nanoparticles; get the above-mentioned gold nanoparticles of 0.1g, platinum acetylacetonate of 0.501g, and 30ml oleylamine into a three-necked flask evenly; 2 In an environment accompanied by vigorous magnetic stirring under certain conditions, the mixed solution was heated to 80 °C at a heating rate of 3 °C / min, the solution turned black, and the reaction was maintained at this temperature for 2 h; after the reaction was completed, the mixed solution was coole...

Embodiment 2

[0044] 0.302g of HAuCl 4 4H 2 O and 30ml of oleylamine (OAm) were mixed evenly and added to a 100ml three-necked flask; 2 In an environment accompanied by vigorous magnetic stirring under certain conditions, the mixed solution was heated to 80 °C at a heating rate of 5 °C / min, the solution turned black, and the reaction was maintained at this temperature for 3 hours; after the reaction was completed, the mixed solution was cooled to room temperature, Wash with absolute ethanol and centrifuge to obtain the described gold nanoparticles; get the above-mentioned gold nanoparticles of 0.1g, platinum acetylacetonate of 0.501g, and 30ml oleylamine into a three-necked flask evenly; 2 In an environment accompanied by vigorous magnetic stirring under certain conditions, the mixed solution was heated to 80 °C at a heating rate of 3 °C / min, the solution turned black, and the reaction was maintained at this temperature for 2 h; after the reaction was completed, the mixed solution was cool...

Embodiment 3

[0047] 0.302g of HAuCl 4 4H 2 O and 30ml of oleylamine (OAm) were mixed evenly and added to a 100ml three-necked flask; 2 In an environment accompanied by vigorous magnetic stirring under the same conditions, the mixed solution was heated to 90 °C at a heating rate of 6 °C / min, the solution turned black, and the reaction was maintained at this temperature for 2 hours; after the reaction was completed, the mixed solution was cooled to room temperature, Wash with absolute ethanol and centrifuge to obtain the gold nanoparticles; get the above-mentioned gold nanoparticles of 0.2g, platinum acetylacetonate of 0.501g, and 30ml oleylamine and evenly add them to a three-necked flask; 2 In an environment accompanied by vigorous magnetic stirring under the same conditions, the mixed solution was heated to 70 °C at a heating rate of 8 °C / min, the solution turned black, and the reaction was maintained at this temperature for 5 h; after the reaction was completed, the mixed solution was c...

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Abstract

The invention discloses a branched gold-platinum dual-metal nanoparticle as well as a preparation method and application thereof. The gold-platinum dual-metal nanoparticle has photo-thermal / radio-sensitization combined treatment performance and structurally contains gold-platinum nanoparticles and polyethylene glycol, wherein the gold-platinum nanoparticles are used for photo-thermal / radio-sensitization combined treatment, and polyethylene glycol is used for the surface modification of a thioctic acid terminal of a hydrophilic polymer. The gold-platinum dual-metal nanoparticle can be applied to the photo-thermal / radio-sensitization combined treatment and has the advantages of simplicity in preparation, low cost and remarkable treatment effect.

Description

technical field [0001] The invention relates to a gold-platinum bimetal nanocomposite particle with photothermal / radiation sensitization combined treatment performance, its preparation method and its application in the preparation of photothermal / radiation sensitization synergistic therapeutic agent for diseases such as tumors, belonging to biomedicine materials and nanomedicine. [0002] technical background [0003] Cancer is a leading cause of death worldwide. It not only seriously endangers the health of our people, but also greatly increases the burden of medical expenses on the government and individuals. High-efficiency treatment is of great significance and urgent demand not only for the majority of patients, but also for the development of medical and health services in the whole country and social harmony and stability. In terms of treatment, surgery, radiotherapy and chemotherapy are the three main means of treating malignant tumors. [0004] Photothermal therap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/60A61K41/00A61K33/38A61K33/24A61K9/14A61P35/00
CPCA61K9/146A61K33/24A61K33/38A61K41/0038A61K41/0057A61K2300/00
Inventor 潘越刘旭
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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