55results about How to "Improve the effect of radiotherapy" patented technology

The invention discloses a magnetic-resonance head-neck fixing device. The magnetic-resonance head-neck fixing device comprises head-neck-shoulder padding plates and a head-neck fixing part; the head-neck fixing part comprises a head-neck thermoplastic film and clamping blocks; the head-neck-shoulder padding plates include the head-neck padding plate and the shoulder padding plate connected with the head-neck padding plate; the head-neck padding plate and the shoulder padding plate are put into a head-neck combining coil during using, and are attached to the inner surface of the head-neck combining coil; the head-neck padding plate comprises an arc supporting plate for supporting the head neck part, at least one edge connected to the arc supporting plate and arc enclosing plates extending upwards; a locking part for fixing the head-neck thermoplastic filmis installed on the inner surface of each arc enclosing plate; the shoulder padding plate comprises a shoulder-back supporting plate and arc plates, the arc plates are connected to the edge of the shoulder-back supporting plate and the edge of the head-neck padding plate, a containing cavity for containing the shoulder and the backis enclosed through the arc plates and the shoulder-back supporting plate; installing plates extending in the direction of the head-neck padding plate are located on the arc plates on the two sides ofthe head-neck padding plate, and shoulder pressing mechanisms for pressing the shoulders of a patient are assembled on the installing plates.

The invention relates to a source applicator for anal canal tumor radiotherapy, the source applicator comprises a cylindrical source applicator body of which the diameter is 3cm, wherein the front end of the source applicator body is a spherical arc, the front segment of the source applicator body is a right cylinder segment of which the length is 8.5cm, the right cylinder segment comprises the spherical arc at the front end, the rear segment of the source applicator body is bent in a manner of a 150-degree arc, the arc length of an introvert of an arc-shaped bent segment is 5cm, the source applicator body is internally and axially provided with three source applying tubes which are eccentrically arranged in a semicircle of the introvert side of the cross section of the source applicator body and distributed in a manner of a circular curve, and the distance between the center of each source applying tube and the outer wall of the introvert side of the source applicator body is 5.5cm; an arc between the circle center of the first source applying tube and the circle center of the second source applying tube is equal to an arc between the circle center of the second source applying tube and the circle center of the third source applying tube, and a central angle corresponding to the arc is 60 degrees. The source applicator has a good radiotherapy effect on nidus that part carcinoma of the anal canal spreads outside the anus edge, reduces the possibility of tumor recurrence and facilitates radical cure of the tumor.

The application discloses an on-line analysis method for real-time monitoring of the dose of a radiotherapy patient, comprising the following steps: step 1, a first set of detectors on a head of a connected radiotherapy machine collect the beaming dose data of the radiotherapy machine during each radiotherapy treatment in real time, and transmits the data to a microcontroller in real time, and then the microcontroller transmits the data to a special database in a memory for storage; step two, through a second set of detectors arranged on a human body surface, the real-time radiation dose actually received by the human body surface is sent to the microcontroller through a network, and then passed to the special database in the memory via the microcontroller; and step three, by calling the two sets of data in the special database, the microcontroller uses a comparative analysis module for real-time comparative analysis and calculates the dose error, and through continuous iteration of historical data in the special database, the model is optimized once the error is calculated, so that a recommended dose calculated the next time is more optimized.

The invention relates to an accelerator and an MRI(magnetic resonance imaging)-guided X-ray radiotherapy machine. The accelerator is provided with a magnetron, the magnetron comprises a tube core and a magnet, the magnet employs a master magnet of an MRI system, the tube core is arranged in a main magnetic field, generated by the main magnet, of the MRI system, the axial direction of the tube core is along the direction of the magnetic line of the main magnetic field; and the MRI-guided radiotherapy machine is composed of a radiotherapy machine and an online MRI device, the radiotherapy machine is provided with a linear accelerator and/or a cyclotron for acceleration of charged particles, the linear accelerator and the cyclotron are provided with a magnetron, the online MRI device is provided with a main magnet for forming an MRI main magnetic field, the tube core of the magnetron is arranged in the MRI main magnetic field, the MRI main magnetic field is taken as a constant magnetic field of the magnetron, and the linear accelerator is disposed outside the main magnet. The accelerator provided by the invention is smaller and more compact and generates higher-energy electron beams; and the radiotherapy machine is more compact and can rapidly and accurately deliver the beams to specific irradiation positions.

The invention discloses a special radiotherapy device for a doctor and belongs to the technical field of medical devices. The device comprises a radiotherapy bed body mechanism, a ray machine mechanism and a control system. A human body center line marking device comprising a fixed locking piece, a moving locking piece and a center sheet plate is arranged on the radiotherapy be body. An infrared detector is arranged in the center of a ray outlet of the ray machine and is used for detecting a human body center line. An annular sleeve is arranged between the ray machine and a connection column so that the ray machine is allowed to face the lower part all the time. An infrared emitter is arranged at the joint of the communication column and a rotary disc. An annular infrared receiver is arranged at the center of the rotary disc so as to finish determination of the rotation angle of the emitter in an auxiliary manner. According to the invention, the radiation machine is enabled to be precisely aligned to the center line of the body of a patient; the distance between the radiation machine and the body of the patient is precisely adjusted to be a demand value; precise positioning of a radiotherapy part is conveniently carried out; and in the radiotherapy processes, the distance between the radiation machine and the body of the patient is kept to be the demand value.

The invention discloses a magnetic resonance image-induced radiation therapy system. Magnetic resonance imaging is utilized for carrying out image guiding in a radiotherapy process, and the advantagesof relatively high soft tissue imaging resolution and no ionization radiation hazard are realized; a therapy ray bundle is parallel to the direction of a main magnetic field, so that influence of themain magnetic field on the therapy ray bundle can be reduced to the utmost extent; hardware of a magnetic resonance component and a radiotherapy component can hold still respectively, and irradiatingtreatment in different angles is carried out by adjusting a position of a patient; a support and the magnetic resonance component are compatible, radio frequency interference can not be produced to the magnetic resonance imaging, and in a process that the patient is subjected to treatment in a standing or sitting posture, a position of a lesion always can be in a range of the therapy ray bundle by adjusting the position of the support; and a huge magnet of the magnetic resonance component does not need to be rotated, so that mechanical design complexity is reduced, field intensity of the designed main magnetic field can be improved, and a tumor imaging region is accurately divided.

The present invention belongs to the field of medicine technology, and discloses one kind of mechanical composition, which consists of kurarione, glossy ganoderma or glossy ganoderma polysaccharide, and lentinan. It is used in treating liver cancer, lung cancer, osophagus cancer, hepatitis, etc and may be also used in the operational treatment, radiotherapy and chemotherapy of cancer. It has synergistic effect of the components, may be prepared into different forms and possesses wide application foreground.

An anticancer medical composition for treating cancers, leukemia, hepatitis, hepatocirrhosis, etc is proportionally prepared from gynostemma pentaphyllum or its extract, cordyceps or its extract, cantharidin or its derivative or its analog, and/or toad venom or its extract. It can be used the relative medicine by mixing it with the pharmacologically acceptable auxiliaries.

The invention discloses an ultra-small gold nanoparticle with characteristics of tumor cell mitochondria targeting and rapid kidney clearance. The diameter of the nanoparticle is 2.5 to 5.5 nm. The nanoparticle is prepared by modifying the surface of a gold nanoparticle with cell-penetrating peptide. The cell-penetrating peptide is composed of an FrFKFrFK sequence, a VGPLGV sequence and an EKEKEKEKEKEK sequence. According to the invention, the ultra-small gold nanoparticle is small in size, is beneficial to kidney metabolism and has good biological safety; the multifunctional responsive surface is stable under normal physiological conditions, and internal mitochondria targeting molecules are exposed after the multifunctional responsive surface responds to a tumor microenvironment, so thatthe multifunctional responsive surface is efficiently swallowed by liver tumor cells and targets mitochondria; the enrichment degree of the gold nanoparticle in tumors is increased, and the residencetime of the gold nanoparticle in tumors is prolonged; the gold nanoparticle is in contact with mitochondria, so that the structure and the function of the mitochondria can be destroyed more effectively under the irradiation of radioactive rays; and a better radiotherapy sensitization effect is achieved.

The invention discloses a fixing device for head tumor radiotherapy. The fixing device comprises a base, an arc-shaped plate and a first arc-shaped frame; the upper side of the base is provided with an arc-shaped groove; upper sides of two ends of the arc-shaped groove are each provided with an annular rotating support; the arc-shaped inner side face of the arc-shaped plate is fixedly provided with an arc-shaped bearing plate; the arc-shaped inner face of the bearing plate is fixedly provided with an arc-shaped fixing headrest; arc-shaped connecting rods are connected between the first arc-shaped frame and the arc-shaped plate; the arc-shaped inner side of the first arc-shaped frame is provided with a second arc-shaped frame; a plurality of springs are connected between the second arc-shaped frame and the first arc-shaped frame; and the arc-shaped inner side of the second arc-shaped frame is provided with an arc-shaped frame movable headrest. The fixing device is ingenious in design and simple in structure, realizes all-round fixation of the head of a patient, and can support rotation of the head of the patient when in use, thereby realizing adjustment of the posture of the head ofpatient; and the fixing device adapts to precise radiotherapy of tumors in different positions in the head, relieves the pain of the patient and the labor intensity of medical workers, and improves the comfort of the patient and the working efficiency of the medical workers.

The invention discloses a nano adjuvant of a poly(lactic acid-glycollic acid) covered immunologic stimulant and catalase. The nano adjuvant has a remarkable effect in radiotherapy and immunotherapy. The catalase can be used for effectively improving a tumor hypoxic microenvironment so that the radiotherapy effect is improved; meanwhile, the immunologic stimulant can be used for guiding the immunotherapy on a living body; the activity of regulatory T cells is inhibited, with the help of an immune checkpoint blocking agent; the immunologic stimulant has the effect of inhibiting tumor growth andmetastasis. The invention also discloses a preparation method and application of the nano adjuvant.

The invention discloses a head and neck protection device for non-head and non-neck radiotherapy. The device comprises a vertical plate which is provided with a fixing assembly for fixing and protecting the head of a patient, wherein two mounting rotating rods are fixed to the outer wall of the vertical plate, a rotatable rotating transverse plate is mounted at the top of one mounting rotating rod, a vertical plate is fixed to the top of the rotating transverse plate, a hole is formed in the outer wall of the vertical plate, a sliding rod capable of sliding and limiting is mounted in the hole, and a mouth biting plate is fixed to the end, close to the vertical plate, of the sliding rod. Through cooperation of the structures, radiotherapy is performed in the oral cavity of a patient, meanwhile, the cheek of the patient is massaged through a massage assembly, muscles of the patient are relaxed, the discomfort of the patient is reduced, besides, the situation that salivary secretion is accelerated due to cheek soreness can be further reduced, besides, through cooperation of a liquid suction assembly, certain cleanliness can be kept in the oral cavity of the patient, influence on radiotherapy is reduced, and the treatment effect is improved.

The invention discloses a polyarylethylenebeta-diketone compound or a pharmaceutically acceptable salt thereof and an application of the polyarylethylenebeta-diketone compound or the pharmaceutically acceptable salt thereof. The polyarylethylenebeta-diketone compound provided by the invention has a radiotherapy sensitization effect, and the radiotherapy effect on various tumors can be remarkably improved at a low dosage; a stronger sensibilization effect is shown on low-oxygen environment tumors; the repair process after DNA damage caused by radiotherapy can be effectively inhibited, and an interferon gene activation protein (STING) signal channel can be effectively and synergistically activated. Therefore, when the polyarylethylenebeta-diketone compound provided by the invention is applied to tumor radiotherapy as a radiotherapy sensitization active component, the tumor radiotherapy effect can be greatly improved.

Disclosed herein is a synchrotron control method. The method comprises the following steps: reducing a voltage of an electrostatic cutting board and a voltage of a lateral high frequency excitation electrode, when illumination of the first beam spot of the synchrotron of the synchrotron meets a preset stop condition, the proton beam intensity output by a radiation head is less than or equal to a preset intensity threshold; when the scanning radiation head satisfies a preset illumination condition, the synchrotron returns to an active state. The invention also discloses a synchrotron control device, a device, and a storage medium.