Application of long-chain non-coding RNA CRCAL-3 inhibitor in preparation of product for treating radiotherapy-resistant breast cancer

A long-chain non-coding and inhibitor technology, applied in the field of biomedicine, can solve problems such as unclear mechanism of action, lack of treatment methods, lack of research on radiotherapy-resistant breast cancer, etc., to improve radiotherapy sensitivity, improve radiotherapy effect, and solve Poor results from treatment
CN114832110AActive Publication Date: 2022-08-02SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
Publication Date
2022-08-02

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Abstract

The invention relates to the technical field of biological medicines, in particular to application of a long-chain non-coding RNA CRCAL-3 inhibitor in preparation of a product for treating radiotherapy-resistant breast cancer. The CRCAL-3 inhibitor is used for inhibiting proliferation of radiotherapy-resistant breast cancer cells, and it is found that the CRCAL-3 inhibitor can reverse radiotherapy resistance of the radiotherapy-resistant breast cancer, so that the radiotherapy-resistant breast cancer can recover sensitivity to radiotherapy. A new strategy is provided for treatment and prevention of radiotherapy resistant breast cancer, the survival rate of a patient is increased, and the survival time of the patient is prolonged. Meanwhile, on the basis of CRCAL-3 mechanism research, various treatment strategies of IGF2BP2 inhibition and UBR5 inhibition are provided, so that more effective treatment modes and drugs for resisting breast cancer by radiotherapy are provided, and development of the direction of tumor treatment by radiotherapy is promoted.
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Description

technical field

[0001] The present invention relates to the technical field of biomedicine, and more particularly, to the use of a long-chain non-coding RNA CRCAL-3 inhibitor in the preparation of a product for treating radiotherapy-resistant breast cancer. Background technique

[0002] Breast cancer is the most common malignant tumor in women. The 2021 Cancer Statistics Report shows that the incidence of breast cancer ranks first among all cancers. Radiation therapy is an integral part of the current comprehensive treatment of breast cancer. Radiation therapy for patients with early breast cancer after breast conserving surgery has now become the standard treatment mode for early breast cancer and has been widely used in clinical practice. This treatment method can protect the organ function of patients with breast cancer to the greatest extent; For patients undergoing total mastectomy, as long as there is more than one axillary lymph node metastasis or the primary tumor ...

Claims

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