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Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy

A technology of radiotherapy and chemotherapy, applied in the field of application of pharmaceutical compositions in the preparation of medicaments that increase the effects of radiotherapy and chemotherapy, a method and pharmaceutical composition that can solve the problem of no mention of the therapeutic effects of radiotherapy and chemotherapy Detailed and reliable data, lack of experimental research on preparation methods and doses, lack of other issues, to achieve the effect of increasing radiation sensitivity, enhancing radiation sensitivity, and alleviating symptoms

Inactive Publication Date: 2005-11-02
SUNNY PHARMTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in the current research results on histone deacetylation inhibitors, there is no detailed and reliable data on the use of this substance in the preparation of methods and pharmaceutical compositions for increasing the therapeutic effect of radiotherapy and chemotherapy, let alone the use of this substance. Experimental studies on methods and doses of formulations administered
It also lacks whether the active compounds of different structures in the histone deacetylation inhibitor have similar beneficial effects, etc., so that they cannot be widely and easily used by the society

Method used

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  • Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy
  • Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy
  • Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0067] Preparation Example 1: Preparation of phenyl butyrate oily ointment

[0068] 470 grams of white petrolatum (Riedel-de Haen) (purchased from Merck), 25 grams of paraffin wax 50 / 52 (purchased from Merck), and 5 grams of 4-butyrate (Merck) were placed in a beaker Mix in medium and heat to 70°C to form a paste. The paste was stirred on an electric stirrer at 400 rpm for 1 hour and allowed to cool to room temperature.

preparation Embodiment 2

[0069] Preparation Example 2, the preparation of phenyl butyrate oily ointment

[0070] 65 grams of white petrolatum (Riedel-de Haen), 15 grams of stearyl alcohol (Riedel-de Haen), 260 grams of soft paraffin (Merck), 155 grams of liquid paraffin (Merck), and 5 grams of 4 - Phenyl butyrate (Merck) was mixed in a beaker and heated to 70°C to form a paste. The paste was stirred at 400 rpm for 1 hour and cooled to room temperature.

preparation Embodiment 3

[0071] Preparation Example 3, the preparation of phenyl butyrate emulsion

[0072] First ingredient: 70 grams of Tefose 63®, 20 grams of Superpolystate®, 10 grams of Coster 5000®, 15 grams of Myriyl 318®, 15 grams of Coster 5088® and 15 grams of GMS SE® (available from Merck) were mixed in a beaker and heated to 70°C.

[0073] Second component: 5.739 grams of sodium 4-phenylbutyrate (Triple Crown America, Inc.), 0.125 grams of methylparaben (Merck & Co.), 0.075 grams of propylparaben (propylparaben) (Merck & Co.), and 149.061 grams of deionized water were mixed in a beaker and heated to 70°C.

[0074]The second ingredient was slowly added to the first ingredient and stirring continued at 400 rpm for 5 minutes until a mixture was formed. 2% Stabileze QM(R) (prepared by dissolving 2 g of Stabileze QM(R) in 98 g of deionized water, heating at 70°C with stirring to form a paste, and cooling to room temperature) was added to the mixture and stirred for 5 minutes. The pH of the m...

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Abstract

The present invention provides the use of one kind of medicine composition in preparing medicine for raising the treating effect of radiotherapy and chemotherapy. The medicine composition includes acetylated histone in therapeutically effective amount or its pharmaceutically acceptable salt and pharmaceutically acceptable carrier. The preparation process of the medicine composition includes mixing acetylated histone and the carrier, heating to form paste, stirring and cooling. The medicine composition is used to stimulate the regeneration of epithelium, inhibit proliferation of fibroblast, reduce collagen deposition, inhibit fibrosis factor, reduce pre-inflammatory cell factor, regulate cell period gene and the expression of tumor inhibitor and tumor gene and raise the treating effect of radiotherapy and chemotherapy.

Description

technical field [0001] The present invention relates to the application of the pharmaceutical composition in the treatment of injury induced by chemotherapy and / or radiotherapy, more particularly, relates to the application of a pharmaceutical composition in the preparation of a medicament for increasing the therapeutic effect of radiotherapy and chemotherapy. Background technique [0002] Radiation therapy alone or concurrently or sequentially with chemotherapy is indicated for cancers of the head and neck, chest, skin, anogenital tract, and certain non-malignant diseases such as keloid, desmoid tumor, hemangioma ), arteriovenous malformation (arteriovenous malformation), and histocytosis X (histocytosis X) effective therapy. However, the therapeutic benefit is limited by the mucosal epithelial injury and epidermal radiation syndrome (CRS) induced by radiotherapy or chemotherapy, which include acute reactions such as tissue edema, mucositis, dermatitis, desquamation, etc. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00
Inventor 钟邑林
Owner SUNNY PHARMTECH
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