Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy
A technology of radiotherapy and chemotherapy, applied in the field of application of pharmaceutical compositions in the preparation of medicaments that increase the effects of radiotherapy and chemotherapy, a method and pharmaceutical composition that can solve the problem of no mention of the therapeutic effects of radiotherapy and chemotherapy Detailed and reliable data, lack of experimental research on preparation methods and doses, lack of other issues, to achieve the effect of increasing radiation sensitivity, enhancing radiation sensitivity, and alleviating symptoms
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Publication Date
- 2005-11-02
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
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Abstract
Description
technical field
[0001] The present invention relates to the application of the pharmaceutical composition in the treatment of injury induced by chemotherapy and / or radiotherapy, more particularly, relates to the application of a pharmaceutical composition in the preparation of a medicament for increasing the therapeutic effect of radiotherapy and chemotherapy. Background technique
[0002] Radiation therapy alone or concurrently or sequentially with chemotherapy is indicated for cancers of the head and neck, chest, skin, anogenital tract, and certain non-malignant diseases such as keloid, desmoid tumor, hemangioma ), arteriovenous malformation (arteriovenous malformation), and histocytosis X (histocytosis X) effective therapy. However, the therapeutic benefit is limited by the mucosal epithelial injury and epidermal radiation syndrome (CRS) induced by radiotherapy or chemotherapy, which include acute reactions such as tissue edema, mucositis, dermatitis, desquamation, etc. ...
Examples
preparation Embodiment 1
[0067] Preparation Example 1: Preparation of phenyl butyrate oily ointment
[0068] 470 grams of white petrolatum (Riedel-de Haen) (purchased from Merck), 25 grams of paraffin wax 50 / 52 (purchased from Merck), and 5 grams of 4-butyrate (Merck) were placed in a beaker Mix in medium and heat to 70°C to form a paste. The paste was stirred on an electric stirrer at 400 rpm for 1 hour and allowed to cool to room temperature.
preparation Embodiment 2
[0069] Preparation Example 2, the preparation of phenyl butyrate oily ointment
[0070] 65 grams of white petrolatum (Riedel-de Haen), 15 grams of stearyl alcohol (Riedel-de Haen), 260 grams of soft paraffin (Merck), 155 grams of liquid paraffin (Merck), and 5 grams of 4 - Phenyl butyrate (Merck) was mixed in a beaker and heated to 70°C to form a paste. The paste was stirred at 400 rpm for 1 hour and cooled to room temperature.
preparation Embodiment 3
[0071] Preparation Example 3, the preparation of phenyl butyrate emulsion
[0072] First ingredient: 70 grams of Tefose 63®, 20 grams of Superpolystate®, 10 grams of Coster 5000®, 15 grams of Myriyl 318®, 15 grams of Coster 5088® and 15 grams of GMS SE® (available from Merck) were mixed in a beaker and heated to 70°C.
[0073] Second component: 5.739 grams of sodium 4-phenylbutyrate (Triple Crown America, Inc.), 0.125 grams of methylparaben (Merck & Co.), 0.075 grams of propylparaben (propylparaben) (Merck & Co.), and 149.061 grams of deionized water were mixed in a beaker and heated to 70°C.
[0074]The second ingredient was slowly added to the first ingredient and stirring continued at 400 rpm for 5 minutes until a mixture was formed. 2% Stabileze QM(R) (prepared by dissolving 2 g of Stabileze QM(R) in 98 g of deionized water, heating at 70°C with stirring to form a paste, and cooling to room temperature) was added to the mixture and stirred for 5 minutes. The pH of the m...