9 results about "Phenylbutyrate" patented technology

A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention / suppression agent.

Described herein are methods for disease or disorder associated with GABA transporter 1 (GAT-1) dysfunction. In one aspect described herein, the disease or disorder is associated with one or more solute carrier Family 6 Member 1 (SLC6A1) mutations, and 4-phenylbutyrate, or the pharmaceutically acceptable salt thereof, is administered at a dose of 75 mg / kg / day to 125 mg / kg / day. In another embodiment, the method comprises combined GAT-1 gene therapy combined with administration of 4-phenylbutyrate.

The present invention features palatable pharmaceutical compositions including sodium phenylbutyrate and methods for the treatment of inborn errors of metabolism (e.g., Maple Syrup Urine Disease or Urea Cycle Disorders), neurodegenerative disorders such as Parkinson's disease, spinal muscular atrophy, dystonia, or inclusion-body myositis with such compositions.

The invention discloses application of sodium 4-phenylbutyrate in a product for improving dyszoospermia of obese males, and belongs to the technical field of biological medicines. High-fat feed is adopted to construct a rat obesity model, the protection effect of 4-PBA on the reproductive function of obese rats is studied, and experimental results show that after the 4-PBA intervenes the obese rats, the testosterone content can be obviously increased, the estradiol level can be reduced, the sperm motility can be improved, the sperm malformation rate can be reduced, the spermatogenic dysfunction can be obviously relieved, and the anti-obesity effect on testis tissue morphology, testis tissue morphology, testis tissue morphology, testis tissue morphology and testis tissue morphology can be improved. The functions of supporting cell mitochondria, endoplasmic reticulum and MAM structures are obviously improved, and a new treatment strategy and a new drug target are provided for intervening and controlling obesity induced testis dyszoospermia and improving fertility of obese males.

This invention relates to albumin-bound BODIPY derivatives, their preparation, and applications, belonging to the field of pharmaceutical technology. The albumin-bound BODIPY derivative of this invention couples BODIPY with the albumin-free non-covalent binder 4-(p-iodophenyl)butyric acid (IP), and can be further coupled with a boron thiol compound (BSH). 4-(p-iodophenyl)butyric acid has excellent albumin-binding ability; by utilizing the EPR effect of albumin, tumor-targeted delivery of boron-containing modules (BODIPY or BSH) can be achieved, overcoming the dependence of traditional boron drugs 4-dihydroxyboron-L-phenylalanine (BPA) on the LAT1 transporter protein, and exhibiting a certain degree of broad-spectrum targeting. Simultaneously, the fluorine-18 (…) introduced into the BODIPY structure… 18 The F) atom allows for real-time monitoring of the distribution of boron-containing drugs in vivo via PET-CT, enabling integrated diagnosis and treatment of tumors. This conjugate exhibits high safety and low toxicity, high in vitro cellular uptake, and in vivo animal distribution experiments confirming its excellent tumor targeting properties. This invention can serve as a broad-spectrum targeted boron-containing drug in integrated BNCT diagnosis and treatment.

The invention relates to the technical field of organic synthesis, and provides an impurity compound of phenylbutyrin as well as a preparation method and application thereof. The preparation method of the impurity compound comprises the following steps: reacting phenylbutyric acid with 1, 3-diphenoxy-2-propanol to prepare an intermediate III; replacing the intermediate III with nitrogen and hydrogen, and reacting to obtain an intermediate IV; reacting the intermediate IV with 4-oxo-4-phenylbutyric acid overnight to prepare an intermediate V; sodium borohydride is added into the intermediate V for reduction, and the impurity compound 2-((4-phenylbutyryloxy) propane-1, 3-diyl bis (4-hydroxy-4-phenylbutyrate)) of the phenylbutyrin is obtained. According to the technical scheme, the problem that the quality control related research cannot be promoted due to the lack of effective preparation means of the newly degraded impurities in the storage stage of the phenylbutyrin is solved.

The invention belongs to the technical field of biology, and particularly relates to application of 4-phenylbutyric acid to preparation of medicine for preventing and treating ischemia reperfusion injury, the ischemia reperfusion injury is intestinal ischemia reperfusion injury, and the 4-phenylbutyric acid can be used for preventing and treating the ischemia reperfusion injury by improving the survival rate of the intestinal ischemia reperfusion injury. The 4-phenylbutyric acid can be used for preventing and treating the ischemia reperfusion injury by relieving the intestinal tissue pathological morphology injury and inflammatory factor expression induced by the intestinal ischemia reperfusion and relieving the intestinal barrier function injury induced by the intestinal ischemia reperfusion, and a novel pharmaceutical application is provided for the 4-phenylbutyric acid on the basis of the content disclosed by the invention. A new thought is provided for preventing and treating the ischemia reperfusion injury.

The invention discloses an application of 2-amino-3-phenylbutyric acid in relieving phytotoxicity of plants. Natural 2-amino-3-phenylbutyric acid is subjected to seed soaking treatment, so that plant phytotoxicity can be effectively relieved, the yield of plants is increased, and the germination rate, bud length and root length of plant seeds are remarkably increased. The 2-amino-3-phenylbutyric acid is low in dosage in the application of relieving the plant phytotoxicity, is environmentally friendly, has very high environmental and biological safety, can effectively relieve the plant phytotoxicity, belongs to the field of green and efficient biochemical pesticides, and has very high utilization value and application prospects in agricultural production.

The present application discloses an erythritol analog of phenylbutyrate, and compositions including same. Also disclosed are methods of using the erythritol analog of phenylbutrate.