5 results about "Phenylbutyrate" patented technology

An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone deacetylase, resulting in cell cycle gene expression modulation, reduced cell proliferation, increased cell differentiation, and apoptosis. This agent also initiates fragmentation of genomic DNA, resulting in decreased DNA synthesis and the inhibition of tumor cell migration and invasion. Check for http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41827&idtype=1 active clinical trials or http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41827&idtype=1&closed=1 closed clinical trials using this agent. (http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1440 NCI Thesaurus)