1results about How to "Reduce phosphorylation" patented technology

This invention provides the application of wrinkled papaya polyphenols in the preparation of drugs for treating osteoarthritis. The wrinkled papaya polyphenols are used in the preparation of drugs that reduce the release of pro-inflammatory cytokines and the inflammatory mediator NO in primary chondrocytes, and / or reduce the mRNA expression of inflammation-related enzymes, and / or inhibit the phosphorylation of proteins related to the NF-κB signaling pathway. To test and clarify the anti-inflammatory effect of wrinkled papaya polyphenols, an ADTC5 primary chondrocyte inflammation model was constructed for observation. The results showed that wrinkled papaya polyphenols significantly inhibited IL-1β-induced inflammation in ADTC5 primary chondrocytes, effectively reduced the secretion of pro-inflammatory cytokines (IL-6 and TNF-α), inhibited the release of the inflammatory mediator NO, downregulated the mRNA expression of inflammatory enzymes (iNOS and Cox-2), and reduced the phosphorylation of IκBα and p65 proteins.