2results about How to "Reduce phosphorylation" patented technology

This invention provides the application of wrinkled papaya polyphenols in the preparation of drugs for treating osteoarthritis. The wrinkled papaya polyphenols are used in the preparation of drugs that reduce the release of pro-inflammatory cytokines and the inflammatory mediator NO in primary chondrocytes, and / or reduce the mRNA expression of inflammation-related enzymes, and / or inhibit the phosphorylation of proteins related to the NF-κB signaling pathway. To test and clarify the anti-inflammatory effect of wrinkled papaya polyphenols, an ADTC5 primary chondrocyte inflammation model was constructed for observation. The results showed that wrinkled papaya polyphenols significantly inhibited IL-1β-induced inflammation in ADTC5 primary chondrocytes, effectively reduced the secretion of pro-inflammatory cytokines (IL-6 and TNF-α), inhibited the release of the inflammatory mediator NO, downregulated the mRNA expression of inflammatory enzymes (iNOS and Cox-2), and reduced the phosphorylation of IκBα and p65 proteins.

The invention relates to an RBM-coated CeO2 nano-drug and a preparation method and application thereof.CeO2 nano-particles are wrapped with RBM, then diabetic nephropathy is relieved with the nano RBM drug, and the treatment effect is evaluated; the RBM-CeO2 is passively targeted to the kidney after intravenous injection and releases CeO2 in glomerulus, the RBM-CeO2 enters cells and can inhibit expression of HGMB1 protein, phosphorylation of NF-kB protein is weakened by down-regulation of expression of the HGMB1 protein, glomerular inflammation can be relieved by reduction of phosphorylation of NF-kB, the treatment effect of RBM-CeO2 on relieving of a molecular mechanism of diabetic nephropathy is revealed, and the RBM-CeO2 can be used for treating diabetic nephropathy. The invention aims to provide feasible prevention and treatment measures for patients with diabetic nephropathy.