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2 results about "Ornithine aspartate" patented technology
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L-Ornithine L-aspartate (LOLA), a stable salt of ornithine and aspartic acid, has been used in the treatment of cirrhosis. Weast, Robert C., ed. (1981). Weber AL, Miller SL (1981). "Reasons for the occurrence of the twenty coded protein amino acids" (PDF). "Ornithine Biosynthesis".
Use of ornithine L-aspartate in the preparation of a drug for treating systemic senescence
This invention discloses the application of ornithine aspartate in the preparation of drugs for treating systemic aging. By applying ornithine aspartate to regulate the systemic aging process, this invention can effectively improve hepatocyte dysfunction, restore cell proliferation activity, alleviate cell cycle arrest, and reduce the abnormal expression of aging-related genes and proteins in multiple tissues and organs such as the liver, kidneys, heart, muscles, and fat, thereby delaying the aging process. This technical solution can significantly improve the structural disorder and lipid deposition in aging liver tissue, reduce serum transaminase levels, improve liver function, reduce insulin resistance, inhibit the overexpression of SASP-related inflammatory factors, and maintain metabolic homeostasis. Furthermore, it effectively improves aging phenotypes in multiple tissues and organs. Therefore, this invention has significant technical effects and application potential in delaying systemic aging and improving motor function and metabolic abnormalities.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
Use of ornithine L-aspartate in the preparation of a drug for treating systemic senescence
The application discloses application of ornithine aspartate in preparation of a medicine for treating systematic aging, and the ornithine aspartate is used to regulate the systematic aging process of a body, so that the liver cell dysfunction can be effectively improved, cell proliferation activity can be recovered, cell cycle arrest can be reduced, abnormal expression of aging-related genes and proteins in multiple tissues and organs such as liver, kidney, heart, muscle and fat can be reduced, and the aging process can be delayed. The technical scheme can significantly improve structural disorder and lipid deposition of the aging liver tissue, reduce the serum transaminase level, improve the liver function, reduce insulin resistance, inhibit excessive expression of SASP-related inflammatory factors, and maintain metabolic homeostasis. And the aging phenotype in multiple tissues and organs can be effectively improved. Therefore, the application has significant technical effects and application potential in delaying systematic aging, improving exercise function and metabolic abnormalities.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH