108 results about "Cysteic acid" patented technology

A group of new compounds, N-(all-trans-Retinoyl)-L-cysteic acid, N-(13-cis-Retinoyl)-L-cysteic acid, N-(all-trans-Retinoyl)-L-cysteinesulfinic acid, N-(13-cis-Retinoyl)-L-cysteinesulfinic acid, N-(all-trans-Retinoyl)-L-homocysteic acid, N-(13-cis-Retinoyl)-L-homocysteic acid, and sodium salts of these compounds, including sodium salts of their esters and amides, is shown to exhibit therapeutic effects per se, and which compounds in combination with cytotoxic compounds, such as docetaxel, paclitaxel, doxorubicin and mitoxantrone, exhibit a synergistic effect. These compounds make it possible to manufacture new formulations of poorly soluble pharmaceutical compounds, and the present invention discloses a process of manufacturing water-soluble formulations of such compounds, exemplified by docetaxel, and paclitaxel, exhibiting enhanced pharmacological activity, and formulations of water-soluble pharmaceuticals exemplified by doxorubicin and mitoxantrone, exhibiting improved therapeutic efficacy.

Synthesis of amphoteric soluble starch is carried out by taking starch as raw material, taking any kind from sodium chloroacetate, butanedioic anhydride and 3-chlorine-2-cysteic acid as anion reagent, taking any kind from 3-chlorine-2-hydroxypropyl trimethyl-ammonia chloride and N-(2,3-epoxide)trimethyl-ammonia chloride as cation reagent, catalyzing by composite catalyst, synthesizing the final product at 30-150 degree for 1-8hrs by semi-drying method. It' simple, cheap and efficient, has no after-treatment and waste ejection.

The invention discloses a pharmaceutical composition containing 18 amino acids. The pharmaceutical composition is characterized in that a compound amino acid injection (18AA-V) with varied concentration is prepared by using the following components according to the following ratios of parts by weight: 2.89 of arginine hydrochloride, 2.46 of histidine hydrochloride, 3.79 of leucine, 1.70 of isoleucine, 3.33 of lysine hydrochloride, 2.83 of phenylalanine, 1.97 of threonine, 1.36 of valine, 1.06 of methionine, 0.39 of tryptophan, 3.24 of glycine, 1.88 of alanine, 1.00 of proline, 0.11 of tyrosine, 0.67 of serine, 0.44 of cysteine hydrochloride, 1.15 of aspartic acid, 1.97 of glutamic acid, 50 of xylitol, 0.10 to 0.30 of citric acid and injection water with proper amount. The pharmaceutical composition does not contain a sulfite antioxidant so that the pharmaceutical composition is clinically used in a safer manner. After an accelerated test and a quality test, results show that the pharmaceutical composition is as stable as or more stable than like products (18AA-V) which are sold in the markets and contain sulfites.

This invention relates to C34 peptide derivatives having improved aqueous solubility that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory synctial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

The invention provides a homocysteine dry chemical detection strip and a preparation method thereof. The invention aims to provide a detection strip and a preparation method thereof for fast semiquantitatively/quantitatively detecting homocysteine. The strip is composed of an elongated upper support layer, an elongated lower support layer and test layers in the middle and is divided into a hand-held area and a test area. A diffusion layer, a filtration layer, an enzyme reagent layer and a colour development reagent layer are arranged in the test area from top to bottom. Various grid materials of synthetic fibre materials can be used to prepare the diffusion layer, various filterable materials for separating blood can be used to prepare the filtration layer, and various asymmetric synthetic membranes can be used to prepare the enzyme reagent layer and the colour development reagent layer. A loading hole is arranged in the upper support layer, a sample is sent from the loading pole to the diffusion layer, the sample then permeates into the filtration layer, the enzyme reagent layer and the colour development reagent layer, chemical reactions are performed in the enzyme reagent layer and the colour development reagent layer to change the colour, and the change of optical density in reaction process can be tested through a test pole of the lower support layer.

The invention discloses a pharmaceutical composition containing 18 amino acids. The pharmaceutical composition is characterized in that a compound amino acid injection (18AA-II) with varied concentration is prepared by using the following components according to the following ratios of parts by weight: 1.50 of aspartic acid, 2.50 of glutamic acid, 1.90 of serine, 3.00 of histidine, 3.50 of glycine, 2.50 of threonine, 7.20 of alanine, 4.90 of arginine, 0.20 of tyrosine, 0.20 of cystine, 3.20 of valine, 2.50 of methionine, 0.85 of tryptophan, 3.50 of phenylalanine, 2.50 of isoleucine, 3.40 of leucine, 5.50 of lysine acetate, 2.90 of proline, 0.10 of cysteine hydrochloride and 0.20 of lemon acid. The composition does not contain a sulfite antioxidant so that the pharmaceutical composition is clinically used in a safer manner. After an accelerated test, a test result shows that the pharmaceutical composition containing 18 amino acids is as stable as or more stable than like products which are sold in the markets and contain sulfites.

The invention discloses an acetylcysteine granule and a preparation method thereof, which belong to the new technical field of pharmaceutical preparation, and relates to a new composition of the acetylcysteine granule and the perpetration technology thereof. In the new composition and the preparation technology thereof, the granule mainly consists of acetylcysteine, acrylic resin, mannitol, aspartame and orange essence, and weight ratio of the main constituents is 10:1-50:2-200:0-1:0-1. After being coated with the acrylic resin, the acetylcysteine is mixed with the dry mannitol granule, the aspartame and the orange essence to prepare the acetylcysteine granule; and the prepared acetylcysteine granule has obviously improved stability in wet environment, and the taste of the acetylcysteine granule is greatly improved.

The invention discloses a preparation method and an application of an erythrocyte membrane-coated acid-sensitive polymer prodrug nano drug delivery system, wherein the polymer is formed by connecting sodium polyglutamate and carbocisteine through a peptide bond and then is bonded with an anti-cancer drug taxol to form the polymer prodrug; and the polymer prodrug is coated by an erythrocyte membrane to obtain an erythrocyte membrane-coated acid-sensitive polymer drug delivery system. The drug delivery system has the following characteristics that the particle size is about 100nm, and the shape is a sphere; the drug delivery system is relatively stable in a phosphate buffer and serum; the drug release character is relatively good in an acid environment; the toxicity is obviously reduced in cell experiments; the ingestion of the system by macrophage is obviously reduced; without destructive effect on erythrocyte, the system can be applied to intravenous injection; the circulating time of the system in blood is remarkably longer than that of polymer; and the system has an obvious inhibiting effect on the tumor growth of lung cancer.

The invention discloses a moxifloxacin gelatin capsule, whose contents comprises moxifloxacin or its salts and/or its hydrate and additive, the additive is at least one selected from the following substances: sodium sulfite, sodium acid sulfite, low-molecular proanthocyanidin, L-glutathion, sesame polyphenols, green tea polyphenols, tocopherol, ascorbic acid, isoascorbic acid, vitamin B1, vitamin B2, beta-carotene, soybean isoflavones, L-sulfo-aminolactic acid, pyrophosphoric acid, polyphosphoric acid and their medicinal salts.

A group of new compounds, N-(all-trans-Retinoyl)-L-cysteic acid, N-(13-cis-Retinoyl)-L-cysteic acid, N-(all-trans-Retinoyl)-L-cysteinesulfinic acid, N-(13-cis-Retinoyl)-L-cysteinesulfinic acid, N-(all-trans-Retinoyl)-L-homocysteic acid, N-(13-cis-Retinoyl)-L-homocysteic acid, and sodium salts of these compounds, including sodium salts of their esters and amides, is shown to exhibit therapeutic effects per se, and which compounds in combination with cytotoxic compounds, such as docetaxel, paclitaxel, doxorubicin and mitoxantrone, exhibit a synergistic effect. These compounds make it possible to manufacture new formulations of poorly soluble pharmaceutical compounds, and the present invention discloses a process of manufacturing water-soluble formulations of such compounds, exemplified by docetaxel, and paclitaxel, exhibiting enhanced pharmacological activity, and formulations of water-soluble pharmaceuticals exemplified by doxorubicin and mitoxantrone, exhibiting improved therapeutic efficacy.

The present invention relates to compound glycyrrhizin type powder injection and the preparation method thereof, in particular to compound glycyrrhizin for injection, compound glycyrrhizic acid mono-ammonium S powder injection and the preparation method thereof, which are characterized in that the powder injection consisting of glycyrrhizin (or mono-ammonium glycyrrhizinate), glycine and cysteine hydrochloride that are taken as the active ingredient and the bearer acceptable in medicine and the preparation method are included in the prescription; wherein, the bearer acceptable in medicine contains dextran. The compound glycyrrhizin type powder injection of the present invention can be preserved at room temperature, thus remarkably improving the stability of the medicine, better guaranteeing safety and significance of the medicine and effectively decreasing the storage and transportation cost in production and transportation processes of the medicine.

The present invention relates to a compound glycyrrhizin powder injection preparation and its preparation method. It is made up by using monoammonium salt glycyrrhizinate, cysteine L-hydrochloride, glycine, anhydrous sodium sulfite, calcium sodium egtazate sodium hydroxide solution and sterile injection water through a certain preparation process.

The invention aims to provide a more stable acetylcysteine pharmaceutical composition and a preparation method thereof. The acetylcysteine pharmaceutical composition comprises acetylcysteine and medically acceptable excipients, and the aqueous solution of the composition has a pH value of 7.0-7.5.

The invention discloses an N-acetylcysteine pharmaceutical composition and a preparation method thereof. The pharmaceutical composition comprises an active component and excipients, wherein the active component is N-acetylcysteine and the excipients are cane sugar, sweet orange essence, aspartame, sunset yellow and flow aid. The preparation method is as follows: first, granulating the excipients of cane sugar, sweet orange essence, aspartame and sunset yellow and drying the obtained granules and then carrying out size stabilization to the dried granules; and then mixing with the active component N-acetylcysteine and the flow aid to obtain the granular N-acetylcysteine pharmaceutical composition. The granular N-acetylcysteine pharmaceutical composition provided by the invention is simple in preparation, wherein the raw material N-acetylcysteine is more stable, difficult to be destroyed, and is easy to mix with other excipients.

The invention belongs to the field of a medicine preparation and relates to an inhalant acetylcysteine solution and a preparation method of the inhalant acetylcysteine solution. Physiological seawater is added into the solution, so that the sensitization of the acetylcysteine solution is effectively reduced.

The invention relates to a method for detecting acetylcysteine and related substances thereof. The method adopts a high performance liquid chromatography, wherein the chromatographic condition is that styrene-divinylbenzene copolymer type superpolymer chromatographic column, namely MKF-RP-MH is 4 to 10 mu meters and (100-300)*(8.0-4.0) millimeters (I.D.); the volume ratio of phosphate buffer (pH is between 2 and 5) with mobile phase compositions of 0.01-0.05 mol/L to acetonitrile is 80-95:20-5; the flowing speed is between 0.8 and 1.2 mL/min; the detecting wavelength detected by an ultraviolet detector is 210nm; and the sample size is between 10 and 20 mu liters. The method does not use ionpairreagent, overcomes the defects that ODS column detecting method does not have acid resistance or low organic phase resistance when detecting the acetylcysteine.

The invention discloses an application of a coptis extract used as plant dye in hair dye. The hair dye comprises hair processing agent and a dye preparation, wherein the processing agent is prepared in such as way that thickening agent and water are added into thioglycollic acid amine, sodium thiosulfate, cysteine homologous compound and a derivative and salt thereof or the penetrating agent of clove, ginger and azone; and the dye preparation is prepared in such as way that the coptis extract is used as the plant dye, and the thickening agent and the water are added. During hair dyeing, the hair processing agent and the dye preparation are used together. The product is safe, has no poison and no side effect, and ensures that the dyed hair has smooth and nature hair quality and nature and stable color and luster.

The present invention relates to a compound glycyrrhizin lyophilized powder injection and a preparation method thereof, particularly to compound glycyrrhizin for injection, a compound monoammonium glycyrrhizinate S lyophilized powder injection for injection, and a preparation method thereof. According to the present invention, the prescription contains a lyophilized powder injection comprising glycyrrhizin (monoammonium glycyrrhizinate) adopted as an active component, glycine, cysteine hydrochloride and a disodium hydrogen phosphate-sodium dihydrogen phosphate or dipotassium hydrogen phosphate-potassium dihydrogen phosphate pH buffer, and a preparation method of the lyophilized powder injection; and the drug liquid content is stable during the compound glycyrrhizin lyophilized powder injection preparation process, the finished product can be stored at a room temperature, the injection stability is significantly improved, the safety and the effectiveness of the injection are well ensured, and the warehousing transportation cost during the injection production storage and transportation process is effectively reduced.

An acetylcysteine composition in the form of powder injection with high solubility and stability is prepared from acetylcysteine and pH regulate chosen from sodium dicarbonate, sodium carbonate, sodium hydroxide and bisodium dicarbonate in weight ratio of 1: (0.25-1). Its preparing process is also disclosed.

The invention belongs to the technical field of pharmaceutical preparations, in particular to a compound monoammonium glycyrrhizinate S pharmaceutical composition and a method for preparing a frozen powder injection. The composition is the monoammonium glycyrrhizinate S frozen powder injection and comprises the following components: monoammonium glycyrrhizinate S, cysteine hydrochloride, glycine, anhydrous sodium sulphite, sodium citrate, sodium chloride, sodium hydroxide and water for injection. The frozen powder injection is more stable and safer.

There is provided an infusion solution for peripheral intravenous administration comprising a multichamber vessel constructed in a connectable manner, which separately houses a sugar solution containing sugars, electrolytes and vitamin B1, and an amino acid solution containing amino acids, electrolytes and a sulfite, whereby the vitamin B1 and amino acids are stably maintained. In the infusion solution for peripheral intravenous administration, the sugar solution contains calcium gluconate, contains no greater than 1.4 g/L sodium lactate, has a pH of 4.0-4.7 and has a titratable acidity of 2-4, the amino acid solution contains 4.0-8.0 g/L sodium lactate, contains no calcium gluconate, has a pH of 6.8-7.2, contains free L-cysteine as cysteine and contains 0.05-0.2 g/L sodium hydrogen sulfite, and after the sugar solution and amino acid solution have been mixed, the infusion solution has a pH of 6.5-7.1 and a titratable acidity of 5-10.

Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH—CH(CH₂—SO₃H)COOH or Arg-Gly-NH—CH(CH₂—SO₃H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers, multimers, cyclic forms, linear forms, drug-conjugates, pro-drugs and their derivatives. Also disclosed are methods for making and using such compounds including methods for inhibiting cellular adhesion to RGD binding sites or delivering other diagnostic or therapeutic agents to RGD binding sites in human or animal subjects.

The invention relates to the technical field of medicines, in particular to a compound monoammonium glycyrrhizate S injection pharmaceutical composition as well as a preparation method and applicationthereof. The pharmaceutical composition is prepared from 400-600g of monoammonium glycyrrhizinate S, 300-500g of cysteine hydrochloride, 4.0-6.0kg of glycine, 400-650g of anhydrous sodium sulfite, 40-60g of disodium edetate, 1.0-3.0kg of sodium chloride and 100-200g of activated carbon; finally, fixing the volume to 180-450L by using water for injection. The preparation method of the pharmaceutical composition comprises the steps of weighing, concentrating, diluting, carrying out sterile filtration, filling and sealing. The compound monoammonium glycyrrhizate S injection pharmaceutical composition can be used for treatment of abnormal liver function caused by acute and chronic and persistent hepatitis, not only improves medicament stability, but also can avoid insoluble particles from generating in medicament, and is good in safety, better in efficacy and more remarkable in curative effect.

The invention discloses an amphiphilic chitosan and its preparation. The amphiphilic chitosan is stearic acid, N-acetyl-L-cysteine grafted chitosan, and has a molecular weight of 10 to 300 kDa. The amphiphilic chitosan of the invention is used as a nano microcapsule embedding wall material, a hydrophobic substance can be embedded to form a water-soluble nano microcapsule solid, or can be used as the embedding wall material of a hydrophilic substance to form water-insoluble nano-capsules. The invention also discloses amphiphilic chitosan-macadamia oil nano microcapsules and a preparation methodand an application thereof. The nano microcapsule is formed by embedding a core material by the wall material, the core material is macadamia oil, and the wall material is the amphiphilic chitosan provided by the invention. The nano-microcapsules provided by the invention have the advantages of high embedding rate, good dispersibility and uniformity, and the macadamia oil has reduced volatility through embedding of the amphiphilic chitosan, and the stability and bioavailability are significantly improved.