Injection acetylcysteine powdery medicinal composition and its making method

Abstract

An acetylcysteine composition in the form of powder injection with high solubility and stability is prepared from acetylcysteine and pH regulate chosen from sodium dicarbonate, sodium carbonate, sodium hydroxide and bisodium dicarbonate in weight ratio of 1: (0.25-1). Its preparing process is also disclosed.

Description

technical field

[0001] The invention relates to a powder injection pharmaceutical composition and a preparation method thereof, in particular to a powder injection pharmaceutical composition containing acetylcysteine ​​aseptic powder and a preparation method thereof. Background technique

[0002] Acetylcysteine ​​(NAC) is the precursor of intracellular glutathione, which can increase the biosynthesis of intracellular glutathione. Recent studies have proved that NAC can act as a carrier of nitric oxide molecules in vivo to exert nitric oxide Physiological effects, promote the dilation of contracted microcirculation blood vessels, effectively increase the oxygen delivery and release of blood to tissues, correct tissue hypoxia, and reduce the occurrence of multiple organ failure. It has been used abroad as a therapeutic drug for acute fulminant hepatic failure caused by drug poisoning, and it has been included in the 1993 and 1998 editions of the British Pharmacopoeia, and its ...