Inhalant acetylcysteine solution and preparation method of inhalant acetylcysteine solution

A technology of acetylcysteine ​​and solution, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problem of reducing the allergenicity of acetylcysteine ​​​​solutions. And other issues

Active Publication Date: 2015-07-29
WUHAN WUYAO SCI & TECH
View PDF5 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, none of the existing inventions mentions reducing

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Inhalant acetylcysteine solution and preparation method of inhalant acetylcysteine solution
  • Inhalant acetylcysteine solution and preparation method of inhalant acetylcysteine solution
  • Inhalant acetylcysteine solution and preparation method of inhalant acetylcysteine solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: Preparation of control sample: preparation of acetylcysteine ​​solution for inhalation without adding physiological sea water (0.3g: 3ml)

[0032] Prescription: Acetylcysteine ​​10kg

[0033] Disodium EDTA 25g

[0034] Add water for injection to 100000ml

[0035] Made 20000 pieces

[0036] Preparation Process:

[0037] (1) Add water for injection of about 60%-80% of the total volume, heat to boil, vacuumize the liquid mixing tank and pipeline, fill with nitrogen to cool the water for injection to 25°C-40°C, and maintain the nitrogen-filled state;

[0038] (2) Take disodium ethylenediaminetetraacetate according to the prescription amount, and stir until completely dissolved;

[0039] (3) Accurately weigh the acetylcysteine ​​according to the prescription amount, and stir until completely dissolved;

[0040] (4) Add 0.1% (w / v) activated carbon according to the concentrated volume of the medicinal solution, and stir for 20 minutes;

[0041] (5) Use a 0...

Embodiment 2

[0047] Embodiment 2: one of the preparation (0.3g:3ml) of acetylcysteine ​​solution for inhalation:

[0048] Prescription: Acetylcysteine ​​10kg

[0049] Disodium EDTA 25g

[0050] Physiological sea water 25000ml

[0051] Add water for injection to 100000ml

[0052] Made 20000 pieces

[0053] Preparation Process:

[0054] (1) Add about 40%-50% of the total volume of water for injection and physiological sea water of the prescribed amount, heat to boiling, vacuumize the liquid mixing tank and pipeline, fill with nitrogen to cool the water for injection to 25°C-40°C, Keep the state filled with nitrogen;

[0055] (2) Take disodium ethylenediaminetetraacetate according to the prescription amount, and stir until completely dissolved;

[0056] (3) Accurately weigh the acetylcysteine ​​according to the prescription amount, and stir until completely dissolved;

[0057] (4) Add 0.1% (w / v) activated carbon according to the concentrated volume of the medicinal solution, and stir ...

Embodiment 3

[0065] Embodiment 3: Preparation (0.3g:3ml) of acetylcysteine ​​solution for inhalation (2)

[0066] Prescription: Acetylcysteine ​​10kg

[0067] Disodium EDTA 25g

[0068] Physiological sea water 10000ml

[0069] Add water for injection to 100000ml

[0070] Made 20000 pieces

[0071] Preparation Process:

[0072] (1) Add about 40%-50% of the total volume of water for injection and physiological sea water of the prescribed amount, heat to boiling, vacuumize the liquid mixing tank and pipeline, fill with nitrogen to cool the water for injection to 25°C-40°C, Keep the state filled with nitrogen;

[0073] (2) Take disodium ethylenediaminetetraacetate according to the prescription amount, and stir until completely dissolved;

[0074] (3) Accurately weigh the acetylcysteine ​​according to the prescription amount, and stir until completely dissolved;

[0075] (4) Add 0.1% (w / v) activated carbon according to the concentrated volume of the medicinal solution, and stir for 20 m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of a medicine preparation and relates to an inhalant acetylcysteine solution and a preparation method of the inhalant acetylcysteine solution. Physiological seawater is added into the solution, so that the sensitization of the acetylcysteine solution is effectively reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an acetylcysteine ​​solution for inhalation and a preparation method thereof. Background technique [0002] Acetylcysteine ​​(acetylcysteine, NAC), the chemical name is N-acetyl-L-cysteine, is the acetyl compound of L-cysteine, and its molecular weight is 163.2, because it contains active sulfhydryl (- SH), was used clinically as an expectorant in the early 1960s, and is an expectorant for the treatment of respiratory infections with good curative effect and high safety. Its molecular formula is as follows: [0003] [0004] Acetylcysteine, as a cysteine ​​derivative, is a mucolytic drug, mainly through the sulfhydryl group in the molecule to break the disulfide bond (-S-S-) of the acidic glycoprotein polypeptide in the mucus sputum, purulent sputum The DNA lysis in the middle can exert a strong sputum dissolving effect on white sticky sputum or sticky sputum purul...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/46A61K9/08A61K31/198A61P11/12
Inventor 向文殿杨波于艳春詹慧郭婷婷
Owner WUHAN WUYAO SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products