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7 results about "Glutamate receptor" patented technology
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Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system and especially prominent in the human brain where it is the body's most prominent neurotransmitter, the brain's main excitatory neurotransmitter, and also the precursor for GABA, the brain's main inhibitory neurotransmitter. Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.
Agent for alleviating clozapine-induced sialorrhea
An object of the present invention to provide a clozapine-induced sialorrhea alleviator. The clozapine-induced sialorrhea alleviator of the present invention contains as an active ingredient dextromethorphan, a compound having an antagonistic action on an NMDA-type glutamate receptor, or a compound having an agonistic action on a sigma-1 receptor.
Owner:CHIBA UNIV
Nucleic Acid-Based Motor End Plate Regulation
The present invention relates to a nucleic acid molecule for modulating neuromuscular transmission, said nucleic acid molecule comprising a sequence encoding one or more motor endplate receptors or fragments thereof. The present invention further relates to a fusion protein, preferably comprising one or more features of one or more of the foregoing Claims, said fusion protein comprising a motor endplate receptor and / or fragments thereof, wherein said motor endplate receptor is an acetylcholine receptor (AChR), a muscle-specific tyrosine kinase (MuSK) receptor, and / or a glutamate receptor, and / or fragments thereof, and / or a neurotoxin, wherein said neurotoxin is botulinum toxin (BoNT) and / or tetanus toxin.
Owner:PRECLINICS DISCOVERY GMBH
Gene editing to provide insect resistance in crops
Methods and compositions to produce insect resistance in plants deploy an engineered glutamate receptor-like protein (GLR3.3) that functions in transmitting wound-induced signals from local to systemic plant organs to trigger synthesis of jasmonic acid, a defense hormone.
Owner:RGT UNIV OF CALIFORNIA
Nanocomposite material capable of adjusting synaptic plasticity and preparation method thereof
The invention discloses a nano composite material capable of adjusting synaptic plasticity and a preparation method thereof, and belongs to the technical field of nano materials. Polylactic acid and polyamino acid form a copolymer, the nano composite material is formed, the polyamino acid is subjected to graft modification, and a glutamic acid receptor inhibitor passes through the polyamino acid terminal, so that the synaptic plasticity can be adjusted. By regulating and controlling the synapses, the transient sensitization of the synapses is accurately intervened, and the abnormal expression of long-term enhancement of the synapses of the central nervous system is controlled, so that the chronic oral pain is relieved.
Owner:SOUTHERN MEDICAL UNIV STOMATOLOGICAL HOSPITAL (GUANGDONG STOMATOLOGICAL HOSPITAL GUANGDONG DENTAL DISEASE PREVENTION & TREATMENT GUIDANCE CENT)
Pharmaceutical composition and application thereof in preparation of drugs for preventing and / or treating erectile dysfunction
PendingCN120617251ASexual disorderHeterocyclic compound active ingredientsSexual impotenceDepressant
The invention belongs to the technical field of biological medicines, and relates to a pharmaceutical composition and application thereof in preparation of medicines for preventing and / or treating erectile dysfunction. A novel brain-gonad axis regulation target medicine for treating obstructive sleep apnea related low testosterone is researched and explored, and through combined medication of a glutamate receptor activator and a GABA receptor inhibitor, signal transmission of olfactory sensory neurons-olfactory bulb GnRH neurons-hypothalamic GnRH neurons-anterior pituitary can be activated, so that the low-testosterone brain-gonad axis regulation target medicine for treating obstructive sleep apnea related low testosterone can be used for treating obstructive sleep apnea related low testosterone. Therefore, the ED symptom is improved, and the treatment of the ED is further realized.
Owner:SHANDONG UNIV QILU HOSPITAL
Clozapine-induced salivation ameliorating agent
The purpose of the present invention is to provide an ameliorating agent for clozapine-induced salivation. The clozapine-induced salivation ameliorating agent according to the present invention contains dextromethorphan, a compound having an antagonistic effect on NMDA-type glutamate receptors, or a compound having an agonistic effect on sigma-1 receptors as an active ingredient.
Owner:CHIBA UNIV
Nucleic acid-based regulation of the motor end plate
PCT designated stageWO2025176788A1Polypeptide with localisation/targeting motifCell receptors/surface-antigens/surface-determinantsTetanusTyrosine
The invention relates to a nucleic acid molecule for modulating neuromuscular transmission, the nucleic acid molecule comprising a sequence encoding one or more receptors of the motor end plate or fragments thereof. The invention further relates to a fusion protein, preferably comprising one or more features of any one or more of the preceding claims, said fusion protein comprising a receptor of the motor end plate and / or fragments thereof, wherein said receptor of the motor end plate is an acetylcholine receptor (AChR), a muscle-specific receptor tyrosine kinase (MuSK), and / or a glutamate receptor, and / or fragments thereof, and / or a neurotoxin, wherein the neurotoxin is a botulinum toxin (BoNT) and / or a tetanus toxin.
Owner:PRECLINICS DISCOVERY GMBH