This invention discloses a heat-inactivated
Lactobacillus rhamnosus. rhamnosus This invention relates to strain CQFP202442 and its application in alleviating exercise-induced fatigue, belonging to the field of microbial technology. The preservation number of this heat-inactivated strain is CGMCC No. 29612. This invention demonstrates that this heat-inactivated strain can significantly prolong the time to exhaustion during running in mice and reduce the degree of
muscle damage; it can increase the levels of T-AOC, CAT, GSH, and GLU in mouse serum, as well as the relative
mRNA expression levels of SOD1, SOD2, and CAT in mouse
muscle tissue; simultaneously, it can upregulate the relative expression levels of related mRNAs in
muscle tissue; and downregulate the levels of LDH, BUN, and CRE in mouse serum. The heat-inactivated strain of this invention can effectively alleviate exercise-induced fatigue through a
dual mechanism of regulating
oxidative stress and myofibrillary protection, exhibiting high safety and good stability.