Molecular marker with auxiliary functions of early diagnosis and prognosis monitoring on colorectal cancer, and application thereof

Abstract

The invention discloses a metabolism marker for screening and monitoring a colorectal cancer. The metabolism marker is beta-hydroxybutyrate, 5-hydroxytryptamine, lysophosphatidyl choline (C14:0), lysophosphatidyl choline (C16:1), alpha-ketobutyrate, fumaric acid, aspartic acid, 2-octene diacid, glycerin, glyceric acid, tryptophan, aconitate, citric acid, ornithine, glycerol monopalmitate, creatinine, methionine and citrulline. The invention also provides a kit with auxiliary functions of early diagnosis and prognosis monitoring on the colorectal cancer. The application of the micromolecule metabolism marker to monitoring of the colorectal cancer not only greatly improves the accuracy, but also has great guiding significance for development of a subsequent clinical application study.

Description

technical field

[0001] The invention relates to the field of biological detection, in particular to molecular markers related to early screening and prognosis monitoring of colorectal cancer and applications thereof. Background technique

[0002] Colorectal cancer (CRC) is one of the four most common malignant tumors in humans today. There are more than one million new cases of colorectal cancer every year in the world, and its mortality rate is as high as 33%, ranking among all cancers. the third. In my country, the morbidity and mortality of colorectal cancer are increasing year by year, and showing a younger trend. The occurrence and development of colorectal cancer is a multi-factor and multi-step process, and the pathogenesis is not yet fully understood. At present, the 5-year survival rate of CRC patients is still lower than 60%, and the clinical efficacy evaluation and prognosis monitoring need to be further improved. The survival rate of CRC patients is closely re...

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