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131 results about "Glyceric acid" patented technology

Glyceric acid is a natural three-carbon sugar acid obtained from the oxidation of glycerol.

Natural oil-based petrolatum and method of making same

The disclosure relates to a composition comprising a triglyceride component wherein: the triglyceride component comprises a mixture of triglycerides and wherein the mixture of triglycerides comprises individual triglycerides comprising one or more ester containing fatty acids and wherein the esters of the ester containing fatty acids are C8-C22 branched or straight chain fatty acid esters and wherein the composition has a drop melting point of between 30° and 70° C. and / or a combined monoglyceride and diglyceride content of between 0.5 and 10 percent.
Owner:CARGILL INC

Method for preparing glyceric acid by catalytically oxidizing glycerol with non-noble metal catalyst

The invention discloses a method for preparing glyceric acid by catalytically oxidizing glycerol with a non-noble metal catalyst, which comprises the following steps of: catalytically oxidizing glycerol under the action of oxygen by taking a CuZrOx composite oxide as a catalyst to obtain glyceric acid; wherein the CuZrOx composite oxide is prepared by a deposition-precipitation method through high-temperature calcination. The internal structure of the catalyst is changed due to introduction of Cu, two metal components are combined more tightly and have strong interaction due to doping of Cu, and meanwhile, compared with a single-metal catalyst, the number of oxygen vacancies of the composite oxide catalyst is increased, the number of strongly acidic sites and strongly basic sites on the surface is increased, and the catalytic activity of the catalyst is improved. According to the present invention, the catalyst has a certain acid-base property so as to produce the good catalysis effect, such that the high glycerol conversion rate and the high glyceric acid selectivity are achieved while the production cost is reduced, and the catalyst can be repeatedly used.
Owner:BEIFANG UNIV OF NATITIES

System and method for triglyceride manufacture

A method can include receiving an oxygenate sample, fractioning the oxygenate sample into one or more fractions, and separating the fractions (e.g. using FAME fractionation, FAEE fractionation, crystallization, solvent extraction, or other similar methods). The fractions can optionally be separated independently. The method can optionally include esterifying carboxylic acids separated from the fractions with glycerol and deodorizing the glycerides.
Owner:SAVOR FOODS LTD

Amorphous-crystalline palladium-based heterophase nanostructures

A general method for synthesizing a series of novel amorphous-crystalline palladium (Pd) -based heterophase nanocatalysts for various promising electrocatalytic applications. The synthesized amorphous-crystalline Pd-PdAu core-island nanocatalyst exhibits high activity, fast reaction kinetics, and excellent long-term catalytic stability toward glycerol oxidation reaction (GOR). Remarkably, the main product of glycerol catalyzed by amorphous-crystalline Pd-PdAu core-island heterostructure is glyceric acid, which possesses the highest commercial value among all the GOR products. The one-pot synthesized amorphous-crystalline Pd-PdPt Janus heterostructure shows remarkable catalytic activity, and fast reaction kinetics towards formic acid oxidation reaction (FOR) in alkaline solution in comparison with commercial Pt / C catalyst and amorphous Pd nanoparticles (NPs), which benefits the development of advanced electrocatalysts for practical applications. The synthesized amorphous-crystalline PdCu Janus heterostructures with bcc phase exhibit high activity, fast reaction kinetics, and excellent long-term catalytic stability for hydrogen evolution reaction (HER) and 5-hydroxymethylfurfural oxidation reaction (HMFOR), benefiting the development of advanced electrocatalysts for practical applications.
Owner:CITY UNIVERSITY OF HONG KONG

Personal care product containing natural oil-based petrolatum

The disclosure relates to a personal care formulation comprising a natural oil-based petrolatum compositions and a method of making the same. The natural oil-based petrolatum comprises a triglyceride component wherein: the triglyceride component contains a plurality hydroxyl containing fatty acid chains and wherein a plurality of the hydroxyl containing fatty acid chains are esterified with a C8-C22 branched or straight chain fatty acid and wherein the triglyceride component: a) contains less than 10% combined monoglycerides and diglycerides or b) has a drop melting point measured by AOCS Standard Procedure Cc 18-80 of between 35 and 70 degrees C.
Owner:CARGILL INC

Bio-based sulfur-phosphorus-free nitrogen-containing borate organic molybdenum antifriction agent as well as preparation method and application of bio-based sulfur-phosphorus-free nitrogen-containing borate organic molybdenum antifriction agent

The invention relates to a bio-based sulfur-phosphorus-free nitrogen-containing borate organic molybdenum antifriction agent and a preparation method and application thereof.The preparation method comprises the following steps that A1, monoglyceride and boric acid are dissolved in methylbenzene and subjected to a heating reaction, triethanolamine is added, the reaction continues, and OBN is obtained; a2, OBN and MoO3 obtained in the step A1 are dissolved in methylbenzene, a heating reaction is conducted in the inert atmosphere, and OBN-Mo is obtained; or B1, dissolving monoglyceride and boric acid in toluene, carrying out a heating reaction, adding triethanolamine, and continuing the reaction to obtain OBN; b2, the OBN obtained in the step B1 and molybdenum acetylacetonate are subjected to a heating reaction in ethyl alcohol, and OBN-Mo-OBN is obtained. Compared with the prior art, the two bio-based sulfur and phosphorus-free nitrogen-containing borate organic molybdenum antifriction agents OBN-Mo and OBN-Mo-OBN can be compounded with ZDDP to prepare lubricating oil, so that the wear resistance of the lubricating oil has a synergistic interaction effect.
Owner:SHANGHAI INST OF TECH

Bio-based composite materials and method for manufacturing the same

To provide a bio-based composite material with excellent mechanical properties and high environmental performance.SOLUTION: A bio-based composite material comprises: 45 to 75 pts.wt. of polypropylene; and 25 to 55 pts.wt. of biomass material, wherein the biomass material is any one of or a combination of two or three of a plasticized starch, a modified biogenic calcium, and a modified cellulose. The bio-based composite material further comprises: 1 to 3 pts.wt. of a linear low-density polyethylene as a modifier; 3 to 5 pts.wt. of an ethylene-vinyl acetate copolymer as a modifier; 2 to 3 pts.wt. of a monoglyceride as a surfactant; 2 to 3 pts.wt. of a polyethylene wax as a modifier; 2 to 3 pts.wt. of a silane coupling agent as a modifier; 0.1 to 0.2 pts.wt. of an antioxidant; and 0 to 3 pts.wt. of a polypropylene graft maleic anhydride as a modifier.SELECTED DRAWING: Figure 1
Owner:VASU NETWORKS HK LTD

Nano noble metal-based oxidation catalyst as well as preparation and application thereof

The invention discloses a nano noble metal-based oxidation catalyst as well as preparation and application thereof, and belongs to the technical fields of preparation of nano catalysts and catalytic conversion of biomass derivatives. The nano noble metal-based oxidation catalyst comprises a core-shell structure as a carrier and nano noble metal particles (such as Pt) loaded on the core-shell structure; wherein the core-shell structure takes a cerium-based oxide as a core and takes a metal oxide as a shell; pt is loaded on the surface of the cerium-based oxide. When the catalyst is used for catalyzing glycerol oxidation to prepare glyceric acid, high glycerol conversion rate (as high as 90%) and high glyceric acid selectivity (as high as 99%) under an alkali-free condition can be realized.
Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI

Biomarker composition and application thereof in glioblastoma screening

The invention belongs to the technical field of biological detection, and particularly relates to a biomarker composition and application thereof in glioblastoma screening. The biomarker combination is prepared from one or more of the following metabolites: L-aspartic acid, 3-phosphoric acid-D-glyceric acid, 2-phosphoric acid glyceric acid, hexadecanamide ethanol, D-red sphingosine-1-phosphoric acid, L-goose carnosine, L-alanine-L-lysine, docosahexaenoic acid, leukotriene C4 and urea glutaric acid. According to the invention, a patient with glioblastoma is identified through a plurality of biomarkers, so that the accuracy and comprehensiveness of diagnosis are improved. And the detection can be completed by acquiring body fluid, the sampling is convenient, and the kit is suitable for screening the glioblastoma patients in a large scale, and can effectively overcome the individual difference of the glioblastoma patients.
Owner:ZHUJIANG HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY +1

Alditol oxidase and application thereof

ActiveUS20250115937A1BiofuelsMicroorganism based processesGluconic acidSaturated mutagenesis
An alditol oxidase and application thereof. The method uses D-glucose as a substrate to dock the alditol oxidase derived from Streptomyces coelicolor A3, and selects amino acid residues around an active center for saturation mutagenesis, and screens for alditol oxidase with D-glucose oxidizing activity by plate color development. An amino acid sequence of the alditol oxidase is shown in SEQ ID NO: 2 or SEQ ID NO: 4. The alditol oxidase has the activity of converting D-glucose to D-gluconic acid and D-glyceraldehyde to D-glyceric acid. By using the alditol oxidase, the conversion of D-glucose to pyruvic acid is realized by only three enzymes for the first time and does not depend on any coenzyme.
Owner:SOUTH CHINA UNIV OF TECH

Method for preparing yolk shell structure high-entropy phosphide FeCoNiCrMn-P catalyst by using low-temperature phosphating method

The invention relates to the technical field of crossing of material chemistry and water electrolysis oxygen evolution, in particular to a method for preparing a yolk shell structure high-entropy phosphide FeCoNiCrMn-P catalyst through a low-temperature phosphating method. The method comprises the following steps: dissolving a plurality of nitrates in isopropanol and a glycerin solvent to react to obtain high-entropy glycerate; carrying out hydrothermal reaction on the reacted high-entropy glycerate to generate a high-entropy hydroxide; the high-entropy hydroxide and a phosphorus source are subjected to a low-temperature phosphating reaction to generate the high-entropy phosphide catalyst. According to the invention, the reactant FeCoNiCrMn-P with a graded egg yolk shell structure not only exposes more active sites and provides abundant mass transfer channels, but also provides a uniform environment for heterogeneous catalysis, so that OER is promoted. In addition, the shell layer can also play a role of a protective layer, prevents the active components from deforming and dissolving in the catalytic process, and enhances the stability of the active components. When the current density is 10 mA cm <-2 >, the FeCoNiCrMn-P2 has the best OER performance, and the overpotential of the FeCoNiCrMn-P2 is 329 mV, so that the FeCoNiCrMn-P2 has high practical application value.
Owner:SHANGHAI UNIV

Feed additive for aquaculture as well as preparation method and application of feed additive

The invention belongs to the technical field of aquaculture, and particularly relates to a feed additive for aquaculture as well as a preparation method and application of the feed additive. The preparation method of the feed additive comprises the following steps: (1) weighing the raw material medicines, adding water for soaking, boiling with strong fire, then decocting with slow fire, and collecting first filtrate and first filter residues; (2) adding water into the first filter residue, boiling with strong fire, decocting with slow fire, collecting a second filtrate, and concentrating to obtain a traditional Chinese medicine composition extracting solution; (3) adding yeast powder, peptone, dipotassium phosphate, inositol galactoside and 1, 3-diphosphoglyceric acid into the traditional Chinese medicine composition extracting solution to obtain a fermentation culture medium; and (4) inoculating the lactobacillus fermentum liquid and the bacillus subtilis liquid into the fermentation culture medium for fermentation to obtain a fermentation mixture, and performing centrifugation and freeze drying to obtain the lactobacillus fermentum and bacillus subtilis compound feed. The feed additive for aquaculture is added into feed, so that the growth and development capability of animals can be effectively promoted, the immunocompetence of the animals is improved, and the feed additive has a wide application prospect.
Owner:HUNAN HONGYUE TECH CO LTD

Emulsifying cosmeceutical compositions

Emulsifier compositions with certain ingredients have been shown to emulsify large amounts of dermatologically active ingredients, such as botanical ingredients. Some of the ingredients in these emulsifier compositions include lecithin, glyceryl stearate, cetaryl alcohol, and cetaryl olivate. Successfully emulsified cosmeceutical compositions with 20% dermatologically active ingredients have been generated. These cosmeceutical emulsions were shown to be stable for months of heat or cold, as well as repeated freeze-thaw cycles.
Owner:SWEET CHEMISTRY INC

A novel feed-additive composition

The present invention relates to a novel feed-additive composition for use as prophylactic and therapeutic agents for the treatment of fungal, viral and bacterial infections in humans, animals and aquatic animals, including white spot shrimp virus (WSSV) infection in aquatic species, including crab and shrimp. The additive composition comprises glycerol monolaurate, rosemary oil, nisin peptide, calcium carbonate, piperin, sodium alginate, and carboxymethyl cellulose, and additive composition comprises glycerol monolaurate and saponin-rich extract in the ratio disclosed hereinabove. The said additive composition in a lower concentration can be used for prevention and in a higher concentration can be used for treatment of WSSV infection in aquaculture species. The present invention also relates to a process of manufacturing of the additive composition such as hereinbefore described.
Owner:KYNTOX BIOTECH INDIA PTE LTD

Lubricating oil compositions and use thereof for improving journal bearing durability in internal combustion engines

ActiveUS20250115822A1Crankshaft bearingsBearing componentsGlycerol dioleatePhysical chemistry
This invention relates to a lubricating oil composition comprising or resulting from the admixing of: (i) a base oil; (ii) one or more overbased metal based detergents; and (3) a friction modifier comprising glycerol monooleate, glycerol dioleate, glycerol trioleate or combinations thereof at from 0.2 to 1.0 wt. % of the composition. The composition has a total sulfated ash of less than or equal to 1.0 wt. %, a high temperature high shear viscosity at 150° C. (HTHS) as determined according to ASTM D4683-20 of greater than or equal to 1.8 mPa·s and less than or equal to 2.9 mPa·s, and a total phosphorous level of less than or equal to 0.080 wt. %. The inventive composition provides a 10% to 80% decrease in journal bearing wear as measured by wear scar volume in μm3 using the MTM-R test method compared to a lubricating oil composition of comparable HTHS, but not including a friction modifier comprising glycerol monooleate, glycerol dioleate, glycerol trioleate or combinations thereof. Also provided are a method of decreasing journal bearing wear in an internal combustion engine and a method of making the lubricating oil composition.
Owner:INFINEUM INT LTD

Lip Balm Containing Caffeine, Nicotine or Testosterone

A lip balm formulation for applying to a lip including at least one lipid, a surfactant, and a nicotine active, wherein the lip balm formulation includes about 25 wt. % to 60 wt. % of the surfactant based on the total weight of the formulation; wherein the surfactant includes a mixture of mono- and diglycerides and propylene glycol; wherein the surfactant has an HLB of 4; wherein the lip balm formulation includes about 30 wt. % to 60 wt. % of the at least one lipid based on the total weight of the formulation; wherein the at least one lipid includes hydrogenated palm oil; and wherein the surfactant minimizes the surface tension of the at least one lipid.
Owner:SHEARKERSHMAN LAB

Recombinant host cells and methods for the production of glyceric acid and downstream products

Methods and materials related to producing glyceric acid and downstream products are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
Owner:LYGOS INC

Method for preparing glyceric acid through oxidation of ethylene glycol under photoelectrocatalysis

The invention provides a method for preparing glyceric acid through oxidation of ethylene glycol under photoelectrocatalysis, and belongs to the technical field of photoelectrocatalysis. Firstly, a photoelectrode is prepared, then an ethylene glycol aqueous solution added with potassium chloride and potassium sulfate is used as a reaction solution, after the pH value is adjusted by sodium hydroxide, a photoelectrocatalysis ethylene glycol oxidation reaction is carried out, and C3 products such as glyceric acid are prepared. According to the invention, preparation of C3 products such as glyceric acid from a C2 raw material (ethylene glycol) is realized innovatively based on a broken bond coupling process of ethylene glycol, and development and application of ethylene glycol oxidation reaction in the photoelectric field are greatly broadened; compared with a thermocatalysis mode, ethylene glycol is adopted as a single raw material for the first time, catalysis under the conditions of high temperature, high pressure, precious metal or strong alkalinity is not needed, and an innovative solution is provided for efficient and high-selectivity value-added conversion of ethylene glycol and green synthesis of glyceric acid; and a new technical route is provided for realizing preparation of a long-chain compound by increasing a carbon chain.
Owner:DALIAN UNIV OF TECH

Polypropylene resin composition

A polypropylene resin composition comprising: A) from 10% to 70% by weight of an ultra high molecular weight propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units; b) from 30% to 90% by weight of an organic material selected from the group consisting of: organic acid esters; adipate and glycerate; a phosphate ester; paraffin; wax; and mineral oil.
Owner:BASELL POLIOLEFINE ITALIA SRL

A method for preparing glyceric acid by electrocatalytic oxidation of glycerol

A method for preparing glyceric acid by electrocatalytic oxidation of glycerol is disclosed. Glycerol is used as a reactant and electrocatalytically oxidized in a potassium hydroxide solution at room temperature and normal pressure to prepare glyceric acid. The catalyst is a platinum catalyst supported on lanthanum oxyfluoride, and the platinum loading is no more than 20 wt%. The catalyst is prepared as follows: lanthanum nitrate and ammonium fluoride are fully dissolved in an aqueous solution at a molar ratio of 1:1, adjusted to a weakly alkaline state, stirred evenly, and then centrifuged, washed, and centrifuged to obtain a lanthanum oxyfluoride carrier; the resulting solid is dried, calcined, and ground to obtain the lanthanum oxyfluoride; platinum nitrate and lanthanum oxyfluoride are heated and stirred in water to evaporate to dryness, so that the platinum is impregnated on the lanthanum oxyfluoride carrier; the resulting solid is dried and calcined, and the platinum nitrate is converted to platinum after calcination. The catalyst for preparing glyceric acid by electrocatalytic oxidation of glycerol has high catalytic reaction activity and simple reaction conditions.
Owner:XIAMEN UNIV

Electrocatalyst and application thereof in oxidation of biomass alcohol terminal hydroxyl

The invention belongs to the field of catalytic oxidation of biomass alcohol, and particularly relates to an electrocatalyst and application thereof in oxidation of hydroxyl at a biomass alcohol terminal. The preparation method of the catalyst comprises the following steps: heating, stirring and dissolving a mixed solution of polyvinylpyrrolidone, ascorbic acid, potassium bromide and ethylene glycol, adding a copper sulfate solution, adding a mixed solution of chloroauric acid and chloropalladic acid, stirring and heating, centrifugally washing, and drying in vacuum to obtain the catalyst. The biomass alcohol terminal hydroxyl group can be green and efficiently converted under the conditions of normal temperature and normal pressure; the method comprises the following steps: loading a catalyst on the surface of carbon paper to serve as an anode of an electrolytic tank, and carrying out electrocatalytic oxidation in a potassium hydroxide solution by taking glycerol, 1, 2-propylene glycol and ethylene glycol as reactants to prepare glyceric acid, lactic acid and glycollic acid; results show that the selectivity of glyceric acid is 52%, the selectivity of lactic acid is 53%, and the selectivity of glycollic acid is 99%. The prepared catalyst is high in catalytic activity, and a new method is provided for catalyzing oxidation of biomass alcohol terminal hydroxyl.
Owner:JIANGSU UNIV

Lipid-containing compositions and their application in clearing protein-bound toxins in liver failure

A lipid-containing composition, by weight, includes phospholipids, and one or more of vegetable oil, medium-chain triglycerides, antioxidants, and sodium oleate. It has been verified that the various compositions provided by this invention competitively capture protein-bound toxoids in the blood, thereby achieving the purpose of clearing protein-bound toxoids from the blood, especially for patients with liver failure, and also alleviating oxidative stress in patients during dialysis treatment.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Polycyanogen polyhydroxyl bonding agent, preparation method and application of polycyanogen polyhydroxyl bonding agent in hydroxyl-terminated polybutadiene propellant

The invention relates to the technical field of solid propellants, and particularly discloses a polycyanide polyhydroxyl bonding agent, a preparation method and application of the polycyanide polyhydroxyl bonding agent in a hydroxyl-terminated polybutadiene propellant.The preparation method of the bonding agent comprises the steps that acrylonitrile is dropwise added into polyethylene polyamine, and a temperature rise reaction is conducted to prepare an intermediate; and adding glyceric acid into the intermediate, heating to carry out amidation reaction, and distilling until no liquid is distilled off to obtain the target bonding agent. The bonding agent is of a polycyanide polyhydroxyl molecular structure, hydroxyl in the bonding agent and toluene diisocynate can enter a cross-linked network through chemical bonding, cyano can generate a very strong physical adsorption effect with the surfaces of nitramine oxidizing agent particles, and the bonding agent is used as a nitramine or nitramine modified hydroxyl-terminated polybutadiene solid propellant system. After the bonding agent provided by the invention is added into a solid propellant system, the normal-temperature, high-temperature and low-temperature mechanical properties of the solid propellant are obviously improved.
Owner:HUBEI SANJIANG AEROSPACE JIANGHE CHEM TECH

Method for producing Anti-tumor aqueous solution and Anti-tumor aqueous solution

To provide an anti-tumor aqueous solution that is produced using a biopolymer as a starting material.SOLUTION: A method for producing an anti-tumor aqueous solution comprises a step of generating a plasma-irradiated aqueous solution by irradiating a chitosan-containing aqueous solution with plasma. In the method for producing the anti-tumor aqueous solution, a gas used as a plasma generation gas for generating the plasma is selected from among Ar gas, a mixed gas of Ar and N2, a mixed gas of Ar, N2, and O2, or a mixed gas of Ar and O2. The plasma-irradiated aqueous solution thus generated is preferably diluted by means of a culture medium. The anti-tumor aqueous solution comprises glyceric acid, ethyl acetate, and tricarballylic acid.SELECTED DRAWING: Figure 4
Owner:NAT UNIV CORP TOKAI NAT HIGHER EDUCATION & RES SYST

Plants with increased photorespiration efficiency

Presented herein are plants with altered photorespiratory characteristics. Disruption of transport proteins involved in shuttling glycolate and / or glycerate results in reductions in photosynthetic rates, reduced plant growth and alterations in gene expression and photosynthetic metabolite profiles. Such disruptions are also combined with introduced genes expressing components of alternate photorespiratory enzyme pathways to increase photosynthetic efficiency.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES

Metal ion-doped dimanganese trioxide, method of preparation and use thereof

The application discloses a kind of metal ion doped dimanganese trioxide, preparation method and application thereof, manganese salt and metal nitrate are dissolved in glycerol and isopropyl alcohol, the ratio of manganese salt, metal nitrate and glycerol is (0.5-2) mmol: (0.1-0.5) mmol: (4-8) mL, to obtain mixed solution;The mixed solution is kept at 160-200 DEG C, and then the precipitate in the obtained reaction liquid is separated and then washed, dried, to obtain metal ion doped manganese glycerate;Metal ion doped manganese glycerate is calcined at 700-800 DEG C in oxygen atmosphere, to obtain metal ion doped dimanganese trioxide, by metal ion doping, adjust the electronic structure of dimanganese trioxide, improve the conductivity and optimize the ion transmission characteristics, to realize higher specific capacity, longer cycle life and better charge-discharge performance.
Owner:SHAANXI UNIV OF SCI & TECH

A molybdenum cobalt telluride heterostructure material, a preparation method and application thereof

The application belongs to the technical field of inorganic nanometer material synthesis, and relates to a molybdenum cobalt telluride heterostructure material and a preparation method and application thereof. A divalent cobalt salt, a hexavalent molybdenum salt and glycerol are co-precipitated in isopropyl alcohol at a temperature of 160-200 DEG C to synthesize molybdenum cobalt glycerate precursor nanospheres; the molybdenum cobalt glycerate precursor nanospheres are heated to 500-600 DEG C in an air atmosphere for annealing and oxidation treatment to obtain molybdenum cobalt oxide; the molybdenum cobalt oxide and a tellurium source are heated to 550-650 DEG C in a mixed atmosphere of inert and reducing gas for annealing and tellurization treatment, and the molybdenum cobalt telluride heterostructure material is obtained. The molybdenum cobalt telluride heterostructure material provided by the application has a kind of strawberry-like structure formed by cross-linking of nanometer particles, and the molybdenum cobalt telluride heterostructure material with the structure has excellent reversibility and fast sodium storage kinetics and exhibits excellent sodium storage performance.
Owner:QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)

Scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate

The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate. The skin repairing composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of skin repairing polysaccharide; 1%-5% of a yeast lysate; 1%-10% of PEG-5 (Polyethylene Glycol) glycerate triisostearate; and the balance of cosmetically acceptable matrix. The polysaccharide is mannan which is obtained by fermenting Paenibacillus sp.1538, and the weight-average molecular weight of the mannan is 6.15 * 10 < 6 > Da. The specific ultra-high molecular weight polysaccharide is compounded with the saccharomyces cerevisiae extract, and the low-irritation PEG-5 glycerate triisostearate is introduced, so that the compatibility problem that the high molecular weight polysaccharide is easy to flocculate is effectively solved. The composition can form a film immediately, deeply resist inflammation, relieve and repair a physical barrier of scalp, has an excellent synergistic effect, and solves the problem of scalp chemical stimulation injury caused by a traditional surfactant from the source.
Owner:GUANGDONG WANGXIANGBAOCHENG IND CO LTD

A carbonyl reductase mutant and its application in preparing a key intermediate of diltiazem

The present invention relates to a carbonyl reductase mutant and its application in preparing a key intermediate of diltiazem, belonging to the field of bioengineering technology. Specifically, it relates to a carbonyl reductase mutant derived from Candida parapsilosis with significantly improved specific activity, its encoding nucleic acid, a recombinant expression vector and a recombinant expression transformant containing the recombinant carbonyl reductase mutant gene, and the use of the carbonyl reductase mutant as a catalyst in preparing the key intermediate of diltiazem, 2-chloro-3-(4-methoxyphenyl)-3(S)-hydroxypropionic acid methyl ester. Compared with the parent enzyme, the carbonyl reductase mutant of the present invention catalyzes asymmetric reduction to prepare the chiral hydroxy compound 2-chloro-3(S)-hydroxy-3-phenylpropionic acid methyl ester. The chiral hydroxy compound can further generate the cardiovascular drug diltiazem chiral intermediate methyl glycidyl (2R, 3S)-p-methoxyphenyl glycidyl ester through intramolecular cyclization, which has good industrial application prospects.
Owner:EAST CHINA UNIV OF SCI & TECH