54 results about "Glyceric acid" patented technology

The invention discloses a method for preparing glyceric acid by catalytically oxidizing glycerol with a non-noble metal catalyst, which comprises the following steps of: catalytically oxidizing glycerol under the action of oxygen by taking a CuZrOx composite oxide as a catalyst to obtain glyceric acid; wherein the CuZrOx composite oxide is prepared by a deposition-precipitation method through high-temperature calcination. The internal structure of the catalyst is changed due to introduction of Cu, two metal components are combined more tightly and have strong interaction due to doping of Cu, and meanwhile, compared with a single-metal catalyst, the number of oxygen vacancies of the composite oxide catalyst is increased, the number of strongly acidic sites and strongly basic sites on the surface is increased, and the catalytic activity of the catalyst is improved. According to the present invention, the catalyst has a certain acid-base property so as to produce the good catalysis effect, such that the high glycerol conversion rate and the high glyceric acid selectivity are achieved while the production cost is reduced, and the catalyst can be repeatedly used.

The invention relates to a bio-based sulfur-phosphorus-free nitrogen-containing borate organic molybdenum antifriction agent and a preparation method and application thereof.The preparation method comprises the following steps that A1, monoglyceride and boric acid are dissolved in methylbenzene and subjected to a heating reaction, triethanolamine is added, the reaction continues, and OBN is obtained; a2, OBN and MoO3 obtained in the step A1 are dissolved in methylbenzene, a heating reaction is conducted in the inert atmosphere, and OBN-Mo is obtained; or B1, dissolving monoglyceride and boric acid in toluene, carrying out a heating reaction, adding triethanolamine, and continuing the reaction to obtain OBN; b2, the OBN obtained in the step B1 and molybdenum acetylacetonate are subjected to a heating reaction in ethyl alcohol, and OBN-Mo-OBN is obtained. Compared with the prior art, the two bio-based sulfur and phosphorus-free nitrogen-containing borate organic molybdenum antifriction agents OBN-Mo and OBN-Mo-OBN can be compounded with ZDDP to prepare lubricating oil, so that the wear resistance of the lubricating oil has a synergistic interaction effect.

The invention discloses a nano noble metal-based oxidation catalyst as well as preparation and application thereof, and belongs to the technical fields of preparation of nano catalysts and catalytic conversion of biomass derivatives. The nano noble metal-based oxidation catalyst comprises a core-shell structure as a carrier and nano noble metal particles (such as Pt) loaded on the core-shell structure; wherein the core-shell structure takes a cerium-based oxide as a core and takes a metal oxide as a shell; pt is loaded on the surface of the cerium-based oxide. When the catalyst is used for catalyzing glycerol oxidation to prepare glyceric acid, high glycerol conversion rate (as high as 90%) and high glyceric acid selectivity (as high as 99%) under an alkali-free condition can be realized.

The invention belongs to the technical field of aquaculture, and particularly relates to a feed additive for aquaculture as well as a preparation method and application of the feed additive. The preparation method of the feed additive comprises the following steps: (1) weighing the raw material medicines, adding water for soaking, boiling with strong fire, then decocting with slow fire, and collecting first filtrate and first filter residues; (2) adding water into the first filter residue, boiling with strong fire, decocting with slow fire, collecting a second filtrate, and concentrating to obtain a traditional Chinese medicine composition extracting solution; (3) adding yeast powder, peptone, dipotassium phosphate, inositol galactoside and 1, 3-diphosphoglyceric acid into the traditional Chinese medicine composition extracting solution to obtain a fermentation culture medium; and (4) inoculating the lactobacillus fermentum liquid and the bacillus subtilis liquid into the fermentation culture medium for fermentation to obtain a fermentation mixture, and performing centrifugation and freeze drying to obtain the lactobacillus fermentum and bacillus subtilis compound feed. The feed additive for aquaculture is added into feed, so that the growth and development capability of animals can be effectively promoted, the immunocompetence of the animals is improved, and the feed additive has a wide application prospect.

The invention provides a method for preparing glyceric acid through oxidation of ethylene glycol under photoelectrocatalysis, and belongs to the technical field of photoelectrocatalysis. Firstly, a photoelectrode is prepared, then an ethylene glycol aqueous solution added with potassium chloride and potassium sulfate is used as a reaction solution, after the pH value is adjusted by sodium hydroxide, a photoelectrocatalysis ethylene glycol oxidation reaction is carried out, and C3 products such as glyceric acid are prepared. According to the invention, preparation of C3 products such as glyceric acid from a C2 raw material (ethylene glycol) is realized innovatively based on a broken bond coupling process of ethylene glycol, and development and application of ethylene glycol oxidation reaction in the photoelectric field are greatly broadened; compared with a thermocatalysis mode, ethylene glycol is adopted as a single raw material for the first time, catalysis under the conditions of high temperature, high pressure, precious metal or strong alkalinity is not needed, and an innovative solution is provided for efficient and high-selectivity value-added conversion of ethylene glycol and green synthesis of glyceric acid; and a new technical route is provided for realizing preparation of a long-chain compound by increasing a carbon chain.

A polypropylene resin composition comprising: A) from 10% to 70% by weight of an ultra high molecular weight propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units; b) from 30% to 90% by weight of an organic material selected from the group consisting of: organic acid esters; adipate and glycerate; a phosphate ester; paraffin; wax; and mineral oil.

A lipid-containing composition, by weight, includes phospholipids, and one or more of vegetable oil, medium-chain triglycerides, antioxidants, and sodium oleate. It has been verified that the various compositions provided by this invention competitively capture protein-bound toxoids in the blood, thereby achieving the purpose of clearing protein-bound toxoids from the blood, especially for patients with liver failure, and also alleviating oxidative stress in patients during dialysis treatment.

Presented herein are plants with altered photorespiratory characteristics. Disruption of transport proteins involved in shuttling glycolate and / or glycerate results in reductions in photosynthetic rates, reduced plant growth and alterations in gene expression and photosynthetic metabolite profiles. Such disruptions are also combined with introduced genes expressing components of alternate photorespiratory enzyme pathways to increase photosynthetic efficiency.

The application discloses a kind of metal ion doped dimanganese trioxide, preparation method and application thereof, manganese salt and metal nitrate are dissolved in glycerol and isopropyl alcohol, the ratio of manganese salt, metal nitrate and glycerol is (0.5-2) mmol: (0.1-0.5) mmol: (4-8) mL, to obtain mixed solution;The mixed solution is kept at 160-200 DEG C, and then the precipitate in the obtained reaction liquid is separated and then washed, dried, to obtain metal ion doped manganese glycerate;Metal ion doped manganese glycerate is calcined at 700-800 DEG C in oxygen atmosphere, to obtain metal ion doped dimanganese trioxide, by metal ion doping, adjust the electronic structure of dimanganese trioxide, improve the conductivity and optimize the ion transmission characteristics, to realize higher specific capacity, longer cycle life and better charge-discharge performance.

The application belongs to the technical field of inorganic nanometer material synthesis, and relates to a molybdenum cobalt telluride heterostructure material and a preparation method and application thereof. A divalent cobalt salt, a hexavalent molybdenum salt and glycerol are co-precipitated in isopropyl alcohol at a temperature of 160-200 DEG C to synthesize molybdenum cobalt glycerate precursor nanospheres; the molybdenum cobalt glycerate precursor nanospheres are heated to 500-600 DEG C in an air atmosphere for annealing and oxidation treatment to obtain molybdenum cobalt oxide; the molybdenum cobalt oxide and a tellurium source are heated to 550-650 DEG C in a mixed atmosphere of inert and reducing gas for annealing and tellurization treatment, and the molybdenum cobalt telluride heterostructure material is obtained. The molybdenum cobalt telluride heterostructure material provided by the application has a kind of strawberry-like structure formed by cross-linking of nanometer particles, and the molybdenum cobalt telluride heterostructure material with the structure has excellent reversibility and fast sodium storage kinetics and exhibits excellent sodium storage performance.

The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate. The skin repairing composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of skin repairing polysaccharide; 1%-5% of a yeast lysate; 1%-10% of PEG-5 (Polyethylene Glycol) glycerate triisostearate; and the balance of cosmetically acceptable matrix. The polysaccharide is mannan which is obtained by fermenting Paenibacillus sp.1538, and the weight-average molecular weight of the mannan is 6.15 * 10 < 6 > Da. The specific ultra-high molecular weight polysaccharide is compounded with the saccharomyces cerevisiae extract, and the low-irritation PEG-5 glycerate triisostearate is introduced, so that the compatibility problem that the high molecular weight polysaccharide is easy to flocculate is effectively solved. The composition can form a film immediately, deeply resist inflammation, relieve and repair a physical barrier of scalp, has an excellent synergistic effect, and solves the problem of scalp chemical stimulation injury caused by a traditional surfactant from the source.

The present invention relates to a carbonyl reductase mutant and its application in preparing a key intermediate of diltiazem, belonging to the field of bioengineering technology. Specifically, it relates to a carbonyl reductase mutant derived from Candida parapsilosis with significantly improved specific activity, its encoding nucleic acid, a recombinant expression vector and a recombinant expression transformant containing the recombinant carbonyl reductase mutant gene, and the use of the carbonyl reductase mutant as a catalyst in preparing the key intermediate of diltiazem, 2-chloro-3-(4-methoxyphenyl)-3(S)-hydroxypropionic acid methyl ester. Compared with the parent enzyme, the carbonyl reductase mutant of the present invention catalyzes asymmetric reduction to prepare the chiral hydroxy compound 2-chloro-3(S)-hydroxy-3-phenylpropionic acid methyl ester. The chiral hydroxy compound can further generate the cardiovascular drug diltiazem chiral intermediate methyl glycidyl (2R, 3S)-p-methoxyphenyl glycidyl ester through intramolecular cyclization, which has good industrial application prospects.

The invention belongs to the technical field of analysis and detection, and particularly relates to a method for determining glyceric acid in a biological sample, which comprises the following steps: mixing the biological sample with an extracting solution, and extracting to obtain supernate; evaporating and concentrating the supernate, re-dissolving the supernate in an acetonitrile aqueous solution, and filtering to obtain a solution to be detected; the extracting solution comprises an internal standard solution and a solvent, the internal standard solution comprises DL-glyceric acid-2, 3, 3-d3 calcium salt dihydrate and a methanol / water solution, and the solvent is acetonitrile; and testing the to-be-tested solution through liquid chromatography-tandem mass spectrometry, and obtaining the content of glyceric acid in the to-be-tested solution according to the standard curve. The determination steps are simple and convenient, and a large number of samples can be rapidly and simultaneously treated. By adopting an isotope internal standard method for quantification, the matrix effect can be greatly eliminated, and accurate quantification can be achieved. And reference can be provided for clinical early diagnosis of gestational diabetes mellitus.

This invention discloses a two-component multi-shell hollow sulfide nanomaterial, its preparation method, and its applications. The method includes: performing a sulfidation reaction between a cobalt-based binary transition metal glycerate complex and a sulfur source in an organic solvent to prepare the two-component multi-shell hollow sulfide nanomaterial. The preparation method of the two-component multi-shell hollow sulfide nanomaterial provided by this invention is simple, easy to implement, and low in cost; moreover, the prepared two-component multi-shell hollow sulfide nanomaterial exhibits excellent photocatalytic water splitting and hydrogen production activity, with a maximum H2 yield of up to 16.94 mmol·g. ‑1 ·h ‑1 .

The invention relates to the technical field of genetic engineering, in particular to a recombinant bacterium for high-yield serine and application of the recombinant bacterium in fermentation production of serine. The ptsI gene of escherichia coli is knocked out, a glucose PTS system is blocked, glucose transport and phosphorylation and PEP-pyruvic acid associated reaction are relieved, and pyruvic acid is synthesized by reducing serine synthesis precursor 3-phosphoglyceric acid branches. Growth adaptive evolution is further carried out on escherichia coli with the ptsI gene knocked out, an obtained mutant strain is sequenced, the mutation condition is shown in a table 2, and finally the growth rate accelerating chassis bacterium is obtained. Afterwards, by enhancing the expression serine key genes serA, serB and serC of the mutant strain and knocking out serine degradation pathway genes sdaA, sdaB and tdcG, the engineering bacterium for fermentation production of serine is constructed, and the serine yield of the engineering bacterium is remarkably improved.

Process for the preparation of menthanecarbaldehyde, comprising the following steps: - Reaction of menthone with a haloacetic acid ester of the formula XCH2COOR, with X = chlorine or bromine and R = methyl or ethyl, to form the ester of menthaneglycitic acid, - Reaction of the ester of menthaneglycitic acid thus prepared to menthanecarbaldehyde, wherein, in order to react the prepared ester of menthaneglycitic acid to menthanecarbaldehyde, the ester is reacted with a strong base such that the ester is hydrolyzed, and the hydrolysis product, as menthaneglycitic acid or as a salt of menthaneglycitic acid, is decarboxylated after intermediate isolation or without intermediate isolation.

The application discloses brake fluid for One-Box brake-by-wire system and a preparation method thereof, the brake fluid comprises triethylene glycol monomethyl ether borate, glycerol acid ester, triethylene glycol monobutyl ether, tetraethylene glycol monomethyl ether, diethylene glycol, anti-rust agent, antioxidant and pH value regulator. The brake fluid can reduce the friction coefficient to <=0.14 under the SRV test condition, the friction coefficient is reduced by 10% compared with that of traditional brake fluid, the abnormal sound and wear problem caused by poor lubrication of the brake system is effectively solved, and the reliability and safety of the brake system of the new energy vehicle are remarkably improved; in addition, the brake fluid also has low temperature kinetic viscosity (-40 DEG C) <=1000mm 2 / s, the pH value is controlled to be 7.5-8.0, and excellent corrosion prevention performance of the product is ensured.

The invention provides low-viscosity modified natural ester insulating oil and a preparation method thereof, and relates to the technical field of insulating media. Glycerate in the natural ester is converted into short-chain fatty acid ester through transesterification of the natural ester and short-chain alcohol, and then the kinematic viscosity of the product at 40 DEG C is reduced to 8 mm / s or below. According to the prepared low-viscosity modified natural ester insulating oil, the kinematic viscosity is remarkably reduced while excellent biodegradability is reserved, and the bottlenecks of low heat dissipation efficiency, high circulating energy consumption and the like caused by high viscosity of traditional natural ester are effectively overcome; meanwhile, the product also has better low-temperature fluidity and good oxidation stability.

The application discloses a preparation method of a double-shell molybdenum carbide / carbon nanosphere composite wave-absorbing material, which comprises the following steps: preparing molybdenum glycerate nanospheres, preparing polydopamine precursor nanospheres, preparing double-shell hollow structure Mo2C / C nanospheres, and detecting wave-absorbing performance, and the like. Advantages of the application are as follows: during the carbon thermal reduction process, the polydopamine is converted into a carbon skeleton while a reduction reaction occurs with the molybdenum glycerate nanospheres, a layered structure is formed while the molybdenum glycerate nanospheres are converted into molybdenum carbide and a carbon skeleton; a high carbon thermal reduction temperature improves the graphitization degree of the carbon skeleton, which is beneficial to enhancing the dielectric loss capacity of the composite material; the air stored in the double-shell hollow structure improves the inherent impedance of the material; the double-shell hollow structure forms a network structure for confining incident electromagnetic waves, enhances multiple reflection attenuation of the incident electromagnetic waves, and forms a main electromagnetic energy consumption area in the carbon shell, thereby improving electromagnetic energy loss and enhancing wave-absorbing performance.

This invention provides a multi-enzyme cascade catalytic reaction system and its application, belonging to the field of enzyme catalysis production technology. Using glycerol as a raw material, it includes a first module, a second module, and a third module. The first module involves the production of glyceric acid from glycerol under the catalysis of alditol oxidase. The second module contains glyceric acid, ATP, and NAD+. + L-glutamic acid is synthesized into phosphoserine via glycerate kinase, D-3-phosphoglycerate dehydrogenase, and phosphoserine transaminase. The third module involves phosphoserine and nucleophiles being catalyzed by phosphoserine thioylase to synthesize L-cysteine ​​or a non-natural L-α-amino acid. The multi-enzyme cascade catalytic reaction system provided by this invention can catalyze a variety of nucleophiles, yields high products, is low in cost, causes minimal environmental pollution, and is easily industrialized.

The present invention relates to the technical field of solid propellants, and specifically discloses a polycyanide-polyhydroxy bonding agent, a preparation method, and its application in hydroxybutyl propellant. When preparing the bonding agent, acrylonitrile is added dropwise to polyethylene polyamine, and the temperature is raised to react to prepare an intermediate; then glyceric acid is added to the intermediate, the temperature is raised to carry out an amidation reaction, and then distilled until no liquid is distilled out to obtain the target bonding agent. The bonding agent has a polycyanide-polyhydroxy molecular structure, in which the hydroxyl groups can enter a cross-linked network through chemical bonding with toluene diisocyanate, and the cyano group can produce a strong physical adsorption effect with the surface of nitramine oxidant particles, and is used as a nitramine or nitramine-modified hydroxybutyl solid propellant system. After adding the bonding agent provided by the present invention to the solid propellant system, the room temperature, high and low temperature mechanical properties of the solid propellant are significantly improved.

The lipid-containing composition comprises phospholipid, and one or more of vegetable oil, medium-chain triglyceride, an antioxidant and sodium oleate according to a weight ratio. Through verification, various compositions provided by the invention have the effect of competitively capturing the protein-binding toxoid in the blood, so that the purpose of removing the protein-binding toxoid in the blood is achieved, and particularly, the effect of removing the protein-binding toxoid in the blood of a liver failure patient is more obvious; the oxidative stress state of a patient in the dialysis treatment process is also relieved.

The application provides a mycoplasma hyopneumoniae culture medium capable of significantly improving the strain titer and an application thereof, and belongs to the field of veterinary biological products. The mycoplasma hyopneumoniae culture medium is obtained by adding L-asparagine, myo-inositol, arachidonic acid, urea, histamine, sodium pyruvate, valproic acid, glyceric acid, lysophosphatidic acid, L-citrulline, L-glutamine and L-leucine into a KM2 culture medium containing Bama pig serum. The culture medium can significantly improve the growth rate and viable bacterial titer of the mycoplasma hyopneumoniae under a low serum concentration, and reduces the production cost.

The present application relates to a sustained-release pharmaceutical composition of GLP-1 receptor agonist and a preparation method thereof. The composition comprises 0.05-0.5 wt% active ingredient, 45-85 wt% sustained-release agent, and 15-55 wt% viscosity reducer, or comprises 0.05-0.5 wt% active ingredient and 45-99.95 wt% thermal sensitive sustained-release agent. The active ingredient is GLP-1 receptor agonist, the sustained-release agent is polyorthoester, and the viscosity reducer is preferably glycerate compound. The present application also provides a pharmaceutical combination product comprising the sustained-release pharmaceutical composition, and application of the composition in treating metabolic related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improve patient compliance, and shows excellent effects in improving blood glucose control, promoting weight loss, and improving blood lipid level.

A polypropylene resin composition comprising: A) from 10% to 70% by weight of a polypropylene homopolymer composition comprising: T1) from 30% to 70% by weight of a first propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units, T1) from 30% to 70% by weight of a second propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units, and T2) from 30% to 70% by weight of a third propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units; the ethylene derived units have: an intrinsic viscosity (IV), measured in tetrahydronaphthalene at 135 DEG C, ranging from 8.0 dl / g to 13.0 dl / g; t2) from 30% to 70% by weight of a second propylene homopolymer, optionally containing up to 1.0% by weight of ethylene derived units having: an intrinsic viscosity (IV), measured in tetrahydronaphthalene at 135 DEG C, ranging from 2.0 dl / g to 4.5 dl / g; b) from 30% to 90% by weight of an organic material selected from the group consisting of: organic acid esters; adipate; a glycerate; a phosphate ester; paraffin; wax; and mineral oil; wherein the sum of the amount of component A) and the amount of component B) in wt% is equal to 100 wt%.

Provided are a sustained-release pharmaceutical composition of a GLP-1 receptor agonist and a preparation method therefor. The composition contains 0.05 wt% to 0.5 wt% of an active ingredient, 45 wt% to 85 wt% of a sustained-release agent, and 15 wt% to 55 wt% of a viscosity-reducing agent, or contains 0.05 wt% to 0.5 wt% of an active ingredient, and 45 wt% to 99.95 wt% of a thermal sensitive sustained-release agent, wherein the active ingredient is a GLP-1 receptor agonist, the sustained-release agent is a polyorthoester, and the viscosity-reducing agent is preferably a glyceryl ester compound. Further provided are a drug-medical device combination product containing the sustained-release pharmaceutical composition, wherein the drug is the above-described sustained-release drug, and the medical device is a jet microneedle capable of injecting high-viscosity substances, and the use of the composition in the treatment of metabolism-related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improves patient compliance, and exhibits good effects in improving blood glucose control, promoting weight loss, improving blood lipid levels, etc.

The application discloses a composite boronated glyceric acid ester extreme pressure anti-wear additive, which comprises a borate, compound (I), compound (II) and compound (III), and the mass ratio of the compound (I), the compound (II) and the compound (III) is 9-11:47-53:36-46. The application further discloses a preparation method of the composite boronated glyceric acid ester extreme pressure anti-wear additive, specifically comprising the following steps: mixing glycerol, a borate and a solid acid catalyst, adding C4-C 24 fatty acids to perform esterification reaction to obtain a boronated fatty acid glyceride mixture; mixing a boronating agent and a solvent, and adding the boronated fatty acid glyceride mixture to perform reaction. The application further discloses application of the composite boronated glyceric acid ester extreme pressure anti-wear additive in lubricating oil. The anti-wear additive has good oil solubility, excellent extreme pressure anti-wear performance, good thermal stability, and does not have adverse effects on corrosion performance of the lubricating oil.

A lipid-containing composition, by weight, includes phospholipids, and one or more of vegetable oil, medium-chain triglycerides, antioxidants, and sodium oleate. It has been verified that the various compositions provided by this invention competitively capture protein-bound toxoids in the blood, thereby achieving the purpose of clearing protein-bound toxoids from the blood, especially for patients with liver failure, and also alleviating oxidative stress in patients during dialysis treatment.

Presented herein are plants with altered photorespiratory characteristics. Disruption of transport proteins involved in shuttling glycolate and / or glycerate results in reductions in photosynthetic rates, reduced plant growth and alterations in gene expression and photosynthetic metabolite profiles. Such disruptions are also combined with introduced genes expressing components of alternate photorespiratory enzyme pathways to increase photosynthetic efficiency.

This invention provides a recombinant bacterium and its applications. After specific genetic engineering modifications, this recombinant bacterium can synthesize polyhydroxybutyrate (PHB) using one-carbon compounds such as methanol or carbon dioxide as a carbon source. Specifically, the metabolic pathway of the recombinant bacterium, after optimization, enables the efficient synthesis of PHB from methanol as a raw material via metabolic intermediates such as formaldehyde, 3-phosphoglyceric acid, and acetyl-CoA. The recombinant bacterium constructed in this invention can effectively utilize low-cost carbon sources such as methanol or carbon dioxide to produce PHB, and has promising prospects for industrial application.