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Preparation method of L-ornithine-L-aspartate

A technology for aspartate and ornithine, which is applied in the field of aspartate preparation, can solve problems such as application limitations, and achieve the effects of good product quality and high yield

Inactive Publication Date: 2010-09-29
SHANGHAI TIANYE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, barium hydroxide is a toxic substance, and the presence of trace amounts of barium hydroxide limits the application of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of L-ornithine-L-aspartate, the method comprises the following steps:

[0019] (1) 5 kilograms of L-ornithine hydrochloride and 50 kilograms of deionized water are mixed and fed, stirred and reacted at room temperature for 1 hour until the L-ornithine salt is completely dissolved, then add strong basic anion exchange resin, use 20wt % silver nitrate solution to detect chloride ions;

[0020] (2) After the chloride ions have been adsorbed, add 3.95 kg of aspartic acid to the solution, stir and heat to 50°C for 5 hours, filter to remove the anion exchange resin, and concentrate the filtrate at 90°C to a concentration of 1.5 g / ml At this time, add 100 grams of activated carbon to decolorize for 60 minutes. After filtration, heat the filtrate to 60 degrees, stop heating, dropwise add 10 kilograms of absolute ethanol, and cool to room temperature. After the crystallization is complete, filter and reclaim the mother liquor to obtain a wet product. Dry th...

Embodiment 2

[0023] A preparation method of L-ornithine-L-aspartate, the method comprises the following steps:

[0024] (1) Mix 1kgL-ornithine sulfate with 2kg deionized water, stir and react at room temperature for 2h until L-ornithine sulfate is completely dissolved, add strong basic anion exchange resin, continue stirring to obtain a mixed solution, and Utilize concentration to be the silver nitrate solution of 0.1wt% to detect the chloride ion content in the mixed solution;

[0025] (2) After the chloride ions in the mixed solution have been adsorbed by the resin, add 0.8kg of aspartic acid, control the reaction temperature to 40°C, stir and react for 10h, filter and remove the anion exchange resin therein, control the temperature to 40°C, and dissolve the filtrate Concentrate to a concentration of 0.5g / ml to obtain a concentrate;

[0026] (3) Add 10 g of activated carbon to the concentrated solution for decolorization for 60 minutes, then filter to remove the activated carbon, heat t...

Embodiment 3

[0028] A preparation method of L-ornithine-L-aspartate, the method comprises the following steps:

[0029] (1) Mix 1kgL-ornithine phosphate with 20kg deionized water, stir and react at room temperature for 1h until L-ornithine phosphate is completely dissolved, add weakly basic anion exchange resin, continue stirring to obtain a mixed solution, and Utilize the silver nitrate solution that concentration is 50wt% to detect the chloride ion content in the mixed solution;

[0030] (2) After the chloride ions in the mixed solution are completely adsorbed by the resin, add 1.2kg of aspartic acid, control the reaction temperature to 100°C, stir and react for 1h, remove the anion exchange resin by filtering, control the temperature to 90°C, and dissolve the filtrate Concentrate to a concentration of 1.5g / ml to obtain a concentrate;

[0031] (3) Add 0.1 kg of activated carbon to the concentrated solution for decolorization for 20 minutes, then filter to remove the activated carbon the...

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Abstract

The invention relates to a preparation method of L-ornithine-L-aspartate, which comprises the following steps: mixing L-ornithine hydrochloride and deionized water; adding anion exchange resin and continue stirring to obtain a mixed solution; detecting chloride ion content by utilizing a silver nitrate solution; then adding aspartate; removing the resin and concentrating the filtrate after stirring reaction is ended; adding activated carbon for decoloration and dropwise adding absolute ethyl alcohol; then cooling the decolorized filtrate to the room temperature for separating out crystal; and drying the obtained crystal for 8-30h after the filtering is ended. Compared with the prior art, the preparation method does not generate exhaust gas or waste residues, generates low amount of waste water, basically does not need COD (chemical oxygen demand) and BOD (biochemical oxygen demand), almost does not pollute the environment and has high total product yield which can reach more than 80 percent, does not use poisonous raw materials and has higher product quality.

Description

technical field [0001] The invention relates to a preparation method of aspartic acid salt, in particular to a preparation method of L-ornithine-L-aspartic acid salt. Background technique [0002] The existing method for preparing L-ornithine-L-aspartate, such as German patent DE4020980C1, uses arginase to convert arginine into ornithine, and converts arginine into ornithine with L-aspartate during the conversion process. Adjust the pH to directly obtain L-ornithine-L-aspartate. Another example is British patent Brit965,637 and Brit1067,742 and European patent 0477991A1, all use ornithine hydrochloride as raw material, absorb through cation exchange resin, then elute with 3-5% ammonia water, add equivalent amount of Aspartic acid, after concentration, add alcohol or acetone to obtain the product. The disadvantage of adopting the above-mentioned method is that the product yield is not high, only about 50%. Chinese patent CN101100435A uses ornithine sulfate and aspartic aci...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C229/24C07C227/18
Inventor 李华
Owner SHANGHAI TIANYE CHEM
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