Compound prepn of ornithine and asparagic acid for preventing and treating hepatosis and hepatic encephalopathy and its prepn process

A technology of aspartic acid and compound preparations, which is applied in the field of medicine, can solve the problems of complex production methods, unstable product quality, and long production cycles of chemical synthesis methods, and achieve shortened production cycles, stable product quality, and simple production methods. Effect

Inactive Publication Date: 2002-12-11
刘万忠
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  • Abstract
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Problems solved by technology

The unilateral preparation of the salt (Ornithine Aspartate, Ornithine Aspartate) prepared by the reaction of ornithine and aspartic acid under certain conditions and its application in medicine have been reported. The main disadvantages are: The production method of the chemical synthesis method is more complicated, the product quality is unstable, the production cycle is longer, the cost is higher, and there is pollution to the environment

Method used

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Examples

Experimental program
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Embodiment Construction

[0052] In conjunction with compound preparation of the present invention and preparation method embodiment, the present invention is further described as follows:

[0053] Example 1, compound tablet 1: 25g of ornithine hydrochloride, 20g of aspartic acid, 10ml of 1% polyvinylpyrrolidone ethanol solution, 10-40 tablets were prepared in total.

[0054] Preparation method: Take 25g of ornithine hydrochloride and 20g of aspartic acid, mix them evenly, use 10ml of 1% polyvinylpyrrolidone ethanol solution to make a soft material, then use a 20-mesh sieve to granulate, and place the wet granules in a hot air circulation drying box. Add 0.5g of magnesium stearate, mix well, sieve through a 20-mesh sieve for granulation, after measuring the content, carry out tabletting according to the specification that each tablet contains 0.5-2g of aspartic acid, polish and pack to obtain tablets.

[0055] Example 2, compound tablet 2: 10g of ornithine sulfate, 100g of calcium aspartate, 20ml of 1%...

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Abstract

A compound preparation consists of ornithine or its salt and asparagic acid or its salt as well as proper amount of supplementary material; and is prepared into oral preparation or injection through mechanical mixing and other process. The said compound preparation is used for treating various acute hepatitis, chronic hepatosis and hepatic encephacopathy and has the obvious effects of protecting liver and strengthening physique. The preparation process is simple, short in production period and low in cost.

Description

technical field [0001] The invention relates to a compound preparation of ornithine and aspartic acid for preventing and treating liver disease and hepatic encephalopathy and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Ornithine (Ornithine) is an essential amino acid, its chemical name is (S)-2,5-diaminovaleric acid. It is clinically used to treat hyperammonemia. Aspartic acid (Aspartic acid) is also an essential amino acid, and its chemical name is (S)-2-aminosuccinic acid; Aspartic acid can participate in the synthesis of nucleic acids in human liver cells to facilitate the repair of damaged cells. Hepatocyte. The unilateral preparation of the salt (Ornithine Aspartate, Ornithine Aspartate) prepared by the reaction of ornithine and aspartic acid under certain conditions and its application in medicine have been reported. The main disadvantages are: The production method of the chemical syn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61P1/16
Inventor 刘万忠
Owner 刘万忠
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