Multi-thorn nanogold memory alloy stent with radiotherapy sensitization function as well as preparation method and application of multi-thorn nanogold memory alloy stent

A technology of memory alloy and nano-gold, which is applied in the field of medical devices, can solve the problems of tumor restenosis and inability to treat tumors, so as to improve the effect of radiotherapy, increase the average cross-section and absorption coefficient, and improve the effect of metastasis and deposition

Inactive Publication Date: 2021-11-19
福州市微纳新创医疗科技有限公司
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Problems solved by technology

However, the self-expanding stent currently used clinically can only rely on physical expansion to treat esophageal stenosis, and cannot treat the tumor itself, nor can it fundamentally solve the problem of restenosis caused by tumor regrowth

Method used

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  • Multi-thorn nanogold memory alloy stent with radiotherapy sensitization function as well as preparation method and application of multi-thorn nanogold memory alloy stent
  • Multi-thorn nanogold memory alloy stent with radiotherapy sensitization function as well as preparation method and application of multi-thorn nanogold memory alloy stent
  • Multi-thorn nanogold memory alloy stent with radiotherapy sensitization function as well as preparation method and application of multi-thorn nanogold memory alloy stent

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preparation example Construction

[0039] The present invention also provides a method for preparing the prickly nano-gold memory alloy stent described in the above technical solution, comprising the following steps:

[0040] Mixing the scaffold and dopamine in Tris buffer to obtain a polydopamine-coated scaffold;

[0041] mixing the polydopamine-coated stent with a chloroplatinic acid solution, and performing a thermal decomposition reaction to obtain a platinum-coated stent;

[0042] The platinum-coated stent is mixed with ascorbic acid solution and chloroauric acid solution, and an in-situ reduction reaction is carried out to obtain a prickly nano-gold memory alloy stent.

[0043] In the present invention, unless otherwise specified, the preparation materials used are commercially available products well known to those skilled in the art.

[0044]In the present invention, the scaffold and dopamine are mixed in Tris buffer to obtain the polydopamine-coated scaffold. In the present invention, preferably, the...

Embodiment 1

[0061] (1) Preparation of polydopamine-coated stent: firstly, after cleaning the surface of the nickel-titanium alloy stent, the stent is immersed in 8 mmol / L Tris-HCl buffer solution (pH=8.5); dopamine is added to the solution to make the final concentration 2 mg / mL; quickly stir in the dark for 8 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.

[0062] (2) Preparation of platinum-coated stent: immerse the polydopamine-coated stent in 400mL of ethylene glycol, add 1.5mL, 10mg / mL chloroplatinic acid solution; then heat the solution to 110°C for thermal decomposition React for 1 hour; take out the stent, and wash the platinum-coated stent three times with deionized water.

[0063] (3) Preparation of prickly nano-gold memory alloy stent: immerse the platinum-coated stent in 400mL, 100mmol / L ascorbic acid solution, add 1.5mL, 20mg / mL chloroauric acid solution at a stirring speed of 1000rpm, and carry out After the in situ reduc...

Embodiment 2

[0066] (1) Preparation of polydopamine-coated stent: firstly, after cleaning the surface of the nickel-titanium alloy stent, the stent is immersed in 10 mmol / L Tris-HCl buffer solution (pH=8.5); dopamine is added to the solution to make its final concentration 5 mg / mL; quickly stir in the dark for 12 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.

[0067] (2) Preparation of platinum-coated stent: immerse the polydopamine-coated stent in 400mL of ethylene glycol, add 2mL, 15mg / mL of chloroplatinic acid solution; then heat the solution to 110°C for thermal decomposition reaction 1h; take out the stent, and wash the platinum-coated stent three times with deionized water.

[0068] (3) Preparation of prickly nano-gold memory alloy stent: immerse the platinum-coated stent in 400mL, 100mmol / L ascorbic acid solution, add 1.5mL, 20mg / mL chloroauric acid solution at a stirring speed of 1000rpm, and carry out After the in situ reducti...

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Abstract

The invention provides a multi-thorn nanogold memory alloy stent with a radiotherapy sensitization function and a preparation method and application of the multi-thorn nanogold memory alloy stent, and relates to the technical field of medical instruments. The multi-thorn nanogold memory alloy stent with the radiotherapy sensitization function provided by the invention comprises a stent body and a multi-thorn nanogold layer covering the surface of the stent body, wherein the multi-thorn nano-gold layer is composed of a plurality of thorn-shaped nano-gold particles; and the stent body is a columnar latticed stent formed by weaving nickel-titanium alloy wires. The multi-thorn nano-gold memory alloy stent provided by the invention not only has the same physical support treatment effect as a common stent, but also has a radiotherapy sensitization effect; and the multi-thorn nano-gold memory alloy stent can be subjected to multiple times of repeated radiation therapy irradiation, and a stable radiation therapy sensitization effect is kept.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a prickly nano-gold memory alloy stent with radiotherapy sensitization function and its preparation method and application. Background technique [0002] Surgery, radiotherapy and chemotherapy are the three major clinical methods for the treatment of esophageal cancer. However, 60% of the patients with esophageal cancer are already in the middle and advanced stages of cancer when they see a doctor, and they basically lose the opportunity for surgical treatment. However, due to their frail health, patients with advanced stages cannot bear the high side effects. Systemic chemotherapy throughout the body. With the development of technology, radiotherapy with X-rays as the main means can gradually achieve higher penetration depth, higher three-dimensional treatment accuracy, stronger treatment effect and lower treatment side effects, becoming the main treatment for esophageal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/02A61L31/16A61N5/10A61F2/04B82Y5/00B82Y30/00
CPCA61L31/022A61L31/088A61L31/16A61F2/04A61N5/10B82Y5/00B82Y30/00A61F2002/044A61N2005/1098A61L2300/102A61L2300/416A61L2300/606A61L2400/12
Inventor 张璇宋继彬吴颖苏礼超
Owner 福州市微纳新创医疗科技有限公司
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