Multi-thorn nanogold memory alloy stent with radiotherapy sensitization function as well as preparation method and application of multi-thorn nanogold memory alloy stent
A technology of memory alloy and nano-gold, which is applied in the field of medical devices, can solve the problems of tumor restenosis and inability to treat tumors, so as to improve the effect of radiotherapy, increase the average cross-section and absorption coefficient, and improve the effect of metastasis and deposition
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[0039] The present invention also provides a method for preparing the prickly nano-gold memory alloy stent described in the above technical solution, comprising the following steps:
[0040] Mixing the scaffold and dopamine in Tris buffer to obtain a polydopamine-coated scaffold;
[0041] mixing the polydopamine-coated stent with a chloroplatinic acid solution, and performing a thermal decomposition reaction to obtain a platinum-coated stent;
[0042] The platinum-coated stent is mixed with ascorbic acid solution and chloroauric acid solution, and an in-situ reduction reaction is carried out to obtain a prickly nano-gold memory alloy stent.
[0043] In the present invention, unless otherwise specified, the preparation materials used are commercially available products well known to those skilled in the art.
[0044]In the present invention, the scaffold and dopamine are mixed in Tris buffer to obtain the polydopamine-coated scaffold. In the present invention, preferably, the...
Embodiment 1
[0061] (1) Preparation of polydopamine-coated stent: firstly, after cleaning the surface of the nickel-titanium alloy stent, the stent is immersed in 8 mmol / L Tris-HCl buffer solution (pH=8.5); dopamine is added to the solution to make the final concentration 2 mg / mL; quickly stir in the dark for 8 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.
[0062] (2) Preparation of platinum-coated stent: immerse the polydopamine-coated stent in 400mL of ethylene glycol, add 1.5mL, 10mg / mL chloroplatinic acid solution; then heat the solution to 110°C for thermal decomposition React for 1 hour; take out the stent, and wash the platinum-coated stent three times with deionized water.
[0063] (3) Preparation of prickly nano-gold memory alloy stent: immerse the platinum-coated stent in 400mL, 100mmol / L ascorbic acid solution, add 1.5mL, 20mg / mL chloroauric acid solution at a stirring speed of 1000rpm, and carry out After the in situ reduc...
Embodiment 2
[0066] (1) Preparation of polydopamine-coated stent: firstly, after cleaning the surface of the nickel-titanium alloy stent, the stent is immersed in 10 mmol / L Tris-HCl buffer solution (pH=8.5); dopamine is added to the solution to make its final concentration 5 mg / mL; quickly stir in the dark for 12 hours; take out the stent, and wash the polydopamine-coated stent three times with deionized water.
[0067] (2) Preparation of platinum-coated stent: immerse the polydopamine-coated stent in 400mL of ethylene glycol, add 2mL, 15mg / mL of chloroplatinic acid solution; then heat the solution to 110°C for thermal decomposition reaction 1h; take out the stent, and wash the platinum-coated stent three times with deionized water.
[0068] (3) Preparation of prickly nano-gold memory alloy stent: immerse the platinum-coated stent in 400mL, 100mmol / L ascorbic acid solution, add 1.5mL, 20mg / mL chloroauric acid solution at a stirring speed of 1000rpm, and carry out After the in situ reducti...
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