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Vitacoxib long-acting injection as well as preparation method and application thereof

A technology of Vitacoxib and injection, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problem of inability to achieve long-term drug effects and low dissolution of Vitacoxib , poor effect and other problems, to achieve the effect of easy promotion and industrial production, significant long-acting effect and mild conditions

Active Publication Date: 2021-03-12
BEIJING ORBIEPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a long-acting Vitacoxib injection and its preparation method, aiming to solve the problem of the low dissolution and absorption of the active ingredient Vitacoxib in the existing Vitacoxib pharmaceutical composition. Its effect is poor and the problem of inability to achieve long-term drug effect

Method used

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  • Vitacoxib long-acting injection as well as preparation method and application thereof
  • Vitacoxib long-acting injection as well as preparation method and application thereof
  • Vitacoxib long-acting injection as well as preparation method and application thereof

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preparation example Construction

[0025] A kind of preparation method of Vitacoxib long-acting injection of the present invention comprises the following steps:

[0026] 1) Take solvent A and solvent B and mix to obtain a mixed solvent;

[0027] 2) Take the vitacoxib raw material, add it to the mixed solvent obtained in step 1), and fully mix and dissolve to obtain a medicinal solution;

[0028] 3) Filter the medicinal liquid obtained in step 2), pack in cans, and sterilize to obtain a long-acting injection.

[0029] Specifically, in the step 3), when filtering, the pore size of the filter membrane is 0.45-1.00 μm.

[0030] Preferably, in the step 2), the temperature of the medicinal solution is 25-50°C.

[0031] Further, in the step 2), the temperature of the medicinal solution is 30-40°C.

[0032] More specifically, in the step 3), the sterilization temperature is 121° C., and the sterilization time is 30 minutes.

[0033]An application of the vitacoxib long-acting injection of the present invention, the...

Embodiment 1

[0035] A kind of preparation method of Vitacoxib long-acting injection of the present invention comprises the following steps:

[0036] 1) Take solvent A - 5.6L of glycerin formal and solvent B - 4.4L of propylene glycol, and mix to obtain a mixed solvent;

[0037] 2) Take 200 g of vitacoxib crude drug, add it to the mixed solvent obtained in step 1), fully mix and dissolve to obtain a medicinal solution;

[0038] 3) Filter the medicinal liquid obtained in step 2), pack in cans, and sterilize to obtain a long-acting injection.

Embodiment 2

[0040] A kind of preparation method of Vitacoxib long-acting injection of the present invention comprises the following steps:

[0041] 1) Take solvent A—4.0L of glycerin formal and solvent B——polyethylene glycol 6.0L, and mix them to obtain a mixed solvent;

[0042] 2) Take 10 g of vitacoxib crude drug, add it to the mixed solvent obtained in step 1), fully mix and dissolve to obtain a medicinal solution, and the temperature of the medicinal solution is 30°C;

[0043] 3) Filter the medicinal liquid obtained in step 2) with a filter membrane with a pore size of 1 μm, fill the Vitacoxib injection into a vial through the filling equipment, and autoclave it at 121° C. for 30 minutes, and store it. long-acting injections.

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Abstract

The invention provides a Vitacoxib long-acting injection as well as a preparation method and an application thereof. The Vitacoxib long-acting injection comprises Vitacoxib and a mixed solvent, wherein the mass percentage of Vitacoxib in the long-acting injection is 0.1-5.0%; wherein the mixed solvent comprises a solvent A and a solvent B, and the volume percentage of the solvent A in the mixed solvent is 20-80%; wherein the solvent A is glycerol formal, and the solvent B is any one or more of polyethylene glycol 400, polyethylene glycol 200, propylene glycol, ethanol, soybean oil and polyoxyethylene (35) castor oil. The invention also provides the preparation method of the long-acting injection, which comprises the following steps: adding the Vitacoxib raw material medicine into a mixed solvent, mixing, filtering, canning and sterilizing to obtain the long-acting injection. Compared with a traditional preparation, the long-acting injection has the advantages that the administration frequency is reduced, the effective treatment purpose is achieved, the toxic and side effects are reduced, the long-acting effect in clinical use is remarkable, and the long-acting injection is a safe,economical and efficient anti-inflammatory analgesic for pets.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a vitacoxib long-acting injection and its preparation method and application. Background technique [0002] As a new type of compound, Vitacoxib is a cyclooxygenase-2 (COX-2) inhibitor, which has a unique mechanism of action that specifically inhibits COX-2, and is suitable for alleviating the pain caused by osteoarthritis. Pain and inflammation, drugs used in the therapeutic management of bone or soft tissue surgery. [0003] In recent years, the role of Vitacoxib in pet care has become more and more obvious. Vitacoxib is by far the safest selective cyclooxygenase-2 inhibitor for pets. The results of toxicology studies show that Vitacoxib The results of acute toxicity and subchronic toxicity tests of coxib are better than those of similar drugs already on the market, and it is administered continuously for one week at five times the clinically recommended dose, with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/44A61K31/4439A61P29/00
CPCA61K9/0019A61K9/08A61K47/10A61K47/44A61K31/4439A61P29/00
Inventor 周晶何丹婷崔海峰李靖高腾刘传立王松
Owner BEIJING ORBIEPHARM
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