46 results about "Glycerol formal" patented technology

The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.

A composition prepared for treating animals suffering from parasites which parasites are known to be susceptible to at least one of the avermectins, milbemycins or salicylanilides, comprises for example ivermectin in an amount of from 0.1 to 10%(w / v), a solvent selected from the group consisting of glycerol formal, propylene glycol, polyethylene glycol and combinations thereof, and a salicylanilide such as closantel in a required dosage amount for the animal to be treated, typically about 2.5 mg / kg live weight of the animal to be treated, a polymeric species selected from the group consisting of polyvinylpyrrolidone and polyoxypropylene / polyoxyethylene block copolymers, the said polymeric species improving the bioavailability of closantel to the extend that blood plasma levels of the said compound greater than about 20 ppm over period of treatment are achievable.

The invention relates to a low temperature resistant alcohol clean fuel oil, comprising 10% to 30% of ethanol, 65% to 86% of gasoline component oil and 0.01% to 5% of glycerin and / or glycerol formal; and the percentages are weight percentages. The preparation method is as follows: at normal temperature and pressure, gasoline component oil, ethanol, glycerin and / or glycerol formal are added to a reaction kettle in turn; and the required product is obtained after stirring. The invention has very good low temperature resistant effect, and can still be normally used at the temperature of -20 DEG C. Moreover, the invention has simple preparation technology, low production cost, good alcohol oil intersolubility, and difficult lay separation. The fuel in the invention can be used at low temperature, thereby not only having broad market prospect but also having important social meaning.

This invention describes the preparation of fatty acid esters of glycerol formal either by a triglyceride transesterification process or, alternatively, by an esterification process of fatty acids previously obtained from the hydrolysis of triglycerides (fat splitting), with glycerol formal in the presence of an acid or basic catalyst. Also the invention describes the use of these fatty acid esters of glycerol formal prepared by said process as biofuel. In an embodiment, such biofuel is used in the preparation of other biofuels by its mixture with a product selected from a group formed by: glycerol formal, biodiesel, petrol-derived diesel, and mixtures thereof. The biofuels thus obtained are characterized to allow the complete incorporation of the glycerol obtained in the current biodiesel production process in a biodiesel fuel.

The invention discloses an ivermectin slow release injection, which is prepared from the following raw materials in parts by weight: 0.2 to 0.6 part of ivermectin, 1.5 to 4.5 parts of glycerol formal, 10 to 16 parts of propanediol, 2 to 4 parts of ethyl cellulose, 4 to 8 parts of ethyl oleate, 0.2 to 0.4 part of non-ionic surface active agents, wherein the non-ionic surface active agents are tween-80, tween-60 or tween-40. The propanediol and the glycerol formal are used as a solvent and a latent solvent; the ethyl oleate is used as a slow release agent; the product quality and the bioavailability can be well improved; the anthelminthic effect is obvious; the pharmacological activities of the ivermectin can be sufficiently achieved, so that the medicine effect is improved; a better solving scheme is provided for clinically expelling and treating parasites in bodies of livestock.

The present invention discloses a composing prescription of a compound ivermectin injection and a preparation method of the compound ivermectin injection, and belongs to the veterinary medicine technology. The compound ivermectin injection comprises main drugs, a solvent and an antioxidant so as to prepare the stable high-concentration compound ivermectin injection. The injection has characteristics of advanced technology, good stability, broad spectrum, high efficiency, low irritation on the injected site, easy use, and clinical efficiency superior to the single-formula injection. According to the present invention, the raw materials comprise 0.5-5.0% of ivermectin, 2-20.0% of mebendazole, 0.5-5.0% of levamisole hydrochloride, 0.1-1% of the antioxidant, and the balance of the solvent, wherein the antioxidant is one or a mixture selected from thiourea, L-cysteamine hydrochloride, vitamin C, ethylenediamine, sodium hydrogen sulfite, anhydrous sodium sulfite, sodium formaldehydesulfoxylate dihydrate, sodium metabisulfite and the like, and the solvent is one or a mixture selected from propylene glycol, ethanol, glycerol, glycerol formal, dimethylformamide, dimethylacetamide, 2-pyrrolidone and the like.

The invention discloses ivermectin injection of an anti-parasite drug for animals and a preparation method of the ivermectin injection, and belongs to the field of preparations for animals. The ivermectin injection comprises, by weight, 1-3 parts of ivermectin B1, 2-5 parts of vitamin E, 1-4 parts of vitamin D3, 50-100 parts of absolute ethyl alcohol, 1-5 parts of glycerol formal, 0.1-2 parts of ginkgo leaf extracts, 0.5-2 parts of hairyvein agrimonia rhizome extracts, 0.1-3 parts of betelnutpalm seed extracts, 0.1-2 parts of stone-like omphalia extracts and 0.2-1 part of Japanese stemona rootextracts. The vitamins and the plant extracts are added, the ivermectin injection is conveniently absorbed by the animals, an insect-resistant spectrum is widened, drug resistance is reduced, side effects are decreased, growth of the animals is facilitated, and the preparation method is simple and suitable for popularization and use.

The invention discloses a veterinary compound sodium closantel injection which reduces poisoning probability generated when killing the parasites of cows and sheep. The invention belongs to a medical product which contains organic effective components. The preparation method thereof is as follows: 30 to 100kg of sodium closantel is added into 50 to 200L of propanediol, heated to the temperature of 50 to 60 DEG C and stirred for 10 to 25min until the mixture is clear; 1 to 20kg of ivermectin is added into 200L of glycerol formal and stirred for 15 to 20min until the liquid is clear; after the two obtained liquids are combined, the glycerol formal is added to 1000L, stirred uniformly and maintained for 15 to 20min; and after the medicine liquid is clear, the veterinary compound sodium closantel injection is obtained. The invention adopts a compound preparation, is highly effective to the parasites of cows and sheep, can be broadly applied to the parasites of cows and sheep, reduce the infection rate of the parasites and increase the weights of cows and sheep.

The invention discloses a diclazuril liposome which is prepared by the following raw materials in parts by weight: 3-4 parts of diclazuril, 10-20 parts of alpha-pyrrolidone, 30-50 parts of soybean lecithin, 1-10 parts of glycerolformal and 10-20 parts of cholesterol. Compared with the prior art, the diclazuril liposome disclosed by the invention has good stability, solubility and sustained-release property and solves the problem of use methods of the diclazuril; the drug property of the diclazuril can be effectively utilized, and the clinical usage amount can be reduced, so that the safe conversion of the drug in a human body is ensured.

The invention relates to long-acting veterinary ivermectin injection. Every 1000ml long-acting veterinary ivermectin injection contains 10-15g of ivermectin, 500-600ml propylene glycol, 200-300ml of absolute ethyl alcohol, 80-120ml of glycerolformal and 80-120ml of benzyl alcohol. A preparation method of the long-acting veterinary ivermectin injection comprises the following steps: 1) adding ivermectin and propylene glycol into absolute ethyl alcohol, stirring, and dissolving; and 2) adding glycerolformal and benzyl alcohol into the solution obtained in the step 1), uniformly stirring, maintaining constant volume, carrying out sterile filtration, and encapsulating, thus the long-acting veterinary ivermectin injection is obtained. The long-acting veterinary ivermectin injection is stable in quality, effect can last for 72 hours, anthelminthic effect is remarkable, insect bodies inside and outside livestock and poultry can be dispelled, and diseases like swine, bovine and ovine horned toad can be treated by only injecting the long-acting veterinary ivermectin injection once.

The invention relates to a slow-release ivermectin injection for expelling and treating parasites in livestock bodies and a preparation method thereof. The slow-release ivermectin injection mainly overcomes the disadvantages of complex production process, inconvenience in application, inaccurate dosage, poor insect repellent effects and the like of ivermectin preparation drugs in the prior art, the slow-release ivermectin injection mainly comprises ivermectin, ethyl cellulose, ethyl oleate, glycerolformal and benzyl alcohol, and the preparation method is as follows: weighing the prescription dose of the ivermectin and the ethyl cellulose to dissolving in the prescription dose of the benzyl alcohol and the ethyl oleate, using the glycerolformal to fix to a constant volume, and sterilizing with wet and hot steam at 100 DEG C for 30 minutes. The slow-release ivermectin injection has the advantages of simple production process, stable quality, simple drug application operation, accurate dosage, and significant insect repellent effects.

The invention discloses a method for synthesizing glycerol formal through reaction of glycerol and formaldehyde. The method adopts functional ionic liquid as a catalyst and adopts formaldehyde aqueous solution and glycerol as reactants to synthesize a glycerol formal compound. The method has the advantages of mild reaction condition, high product yield, high hexatomic ring product proportion, repeatable use of the catalyst and the like.

The invention discloses a preparation method of a decoquinate solution. The decoquinate solution comprises a solvent, a cosolvent and a pH modifier, wherein the solvent is dimethylformamide, twain, absolute ethyl alcohol, polyethylene glycol and glycerolformal. The preparation is prepared by the following steps at normal temperature and pressure: (1) stirring dimethylformamide and the cosolvent, adding decoquinate to stir and dissolve, adjusting the pH value of the mixed solution to 3.0-4.5 by virtue of the pH modifier, and stirring evenly for later use; (2) adding absolute ethyl alcohol to polyethylene glycol, heating, stirring, and adding dioxolane-4-methanol after 30 minutes, wherein the heating temperature is 70-80 DEG C; and (3) mixing the solution prepared from the step (1) with the solution prepared from the step (2) evenly, naturally cooling to room temperature, adding twain, stirring evenly, precisely filtering and bulking. The production process of the preparation method is safe; the decoquinate solution can be prepared at normal temperature and pressure; the preparation process is simple; the effect for preventing ball insect diseases of poultry is effect; and compared with other anticoccidial drugs, the cost is relatively low.

The invention relates to a non-oily doramectin injection, a preparation method and application thereof. The non-oily doramectin injection comprises the following components: doramectin, glycerol formal and propylene glycol; wherein, the weight percentage of the doramectin is 0.1%-10%, and the glycerol formal and the The propylene glycol forms a mixed solvent, and the mass ratio of the glycerin formal and the propylene glycol in the mixed solvent is (4-8):(2-6). The non-oily doramectin injection has good stability and low irritation.

The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an organic solvent selected from the group consisting of glycerol, propylene glycol, glycerol formal, and (iv) optionally water. The invention further relates to methods of treating or preventing a condition in an animal comprising administering to the animal in need thereof a pharmaceutical composition of the invention.

The invention provides a preparation method for irsogladine maleate, and belongs to the technical field of medicinal and chemical synthesis. The method comprises the following steps: carrying out a condensation reaction between 2,5-dichlorobenzonitrile and dicyandiamide in a non-protic strong polarity solvent with the existence of a basic catalyst to obtain an intermediate II, and enabling the intermediate II and maleic acid to salify in glyceroformol; re-crystallizing a salt in an acetic acid-acetone mixed solution to obtain the irsogladine maleate. The preparation method is easy to operate, high in yield and high in purity, can effectively shorten reaction time, and has a good industrial application value.