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Veterinary long-acting oxytetracycline injection liquid and preparation method thereof

A long-acting oxytetracycline and injection technology, which is applied in the directions of inactive medical preparations, pharmaceutical formulations, inorganic inactive ingredients, etc., can solve the problem of slow release of active pharmaceutical ingredients, reduce the production cost of farmers, and prolong the injection Storage time and other issues to achieve the effect of reducing toxic side effects, increasing drug action time, and improving storage time

Inactive Publication Date: 2020-01-17
成都新亨药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The injection has high quality stability, prolongs the storage time of the injection, and effectively solves the problem of easy discoloration and precipitation of the injection for long-term storage, resulting in a decrease in the effective content. At the same time, the absorption is fast after intramuscular injection, and the active ingredient of the drug is released slowly in the animal body. , to achieve the purpose of long-term effect, reduce the frequency of administration, and reduce the production cost of farmers

Method used

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  • Veterinary long-acting oxytetracycline injection liquid and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 11 g of oxytetracycline dihydrate, 1.5 g of magnesium oxide, and 0.4 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 20g, polyvinylpyrrolidone K12 1g, polyethylene glycol-400 40g, monoethanolamine 1.2g, and the balance is water for injection.

[0028] Its preparation method is as follows: add 10ml of water for injection into a stainless steel bucket, add 0.4g of sodium formaldehyde sulfoxylate during the stirring process, and stir until completely dissolved to obtain a spare solution A; add 10ml of water for injection into the liquid preparation pot, and stir while stirring Add 20g of glycerol methylal, 40g of polyethylene glycol-400, and 1g of polyvinylpyrrolidone K12 in sequence, and stir until completely dissolved to obtain stock solution B; add stock solution A to stock solution B, stir evenly, and h...

Embodiment 2

[0030] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 22 g of oxytetracycline dihydrate, 1.7 g of magnesium oxide, and 0.5 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 30g, polyvinylpyrrolidone K12 5g, polyethylene glycol-400 20g, monoethanolamine 1.4g, and the balance is water for injection.

[0031] Its preparation method is as follows: add 15ml of water for injection into a stainless steel bucket, add 0.5g of sodium formaldehyde sulfoxylate during the stirring process, and stir until it is completely dissolved to obtain a spare solution A; add 15ml of water for injection into the liquid preparation pot, and stir while stirring Add 30g of glycerol methylal, 20g of polyethylene glycol-400, 5g of polyvinylpyrrolidone K12 in sequence, stir until completely dissolved, and obtain stock solution B; add stock solution A to stock solution B, stir well, and hea...

Embodiment 3

[0033] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 22 g of oxytetracycline dihydrate, 1.7 g of magnesium oxide, and 0.5 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 30g, polyvinylpyrrolidone K12 2g, polyethylene glycol-400 20g, monoethanolamine 1.4g, and the balance is water for injection.

[0034] Its preparation method is as follows: add 15ml of water for injection into a stainless steel bucket, add 0.5g of sodium formaldehyde sulfoxylate during the stirring process, and stir until it is completely dissolved to obtain a spare solution A; add 15ml of water for injection into the liquid preparation pot, and stir while stirring Add 30g of glycerol methylal, 20g of polyethylene glycol-400, and 2g of polyvinylpyrrolidone K12 in sequence, and stir until completely dissolved to obtain reserve solution B; add reserve solution A to reserve solution B, stir e...

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Abstract

The invention discloses veterinary long-acting oxytetracycline injection liquid and a preparation method thereof. The veterinary long-acting oxytetracycline injection liquid contains oxytetracycline dihydrate, magnesium oxide, sodium formaldehyde sulfoxylate, glycerol formal, polyvinylpyrrolidone K12, polyethylene glycol-400, monoethanolamine and water for injection. According to the veterinary long-acting oxytetracycline injection liquid, the combined action of the oxytetracycline dihydrate with the low impurity content and the high purity, the sodium formaldehyde sulfoxylate, the magnesium oxide and the glycerol formal improves stability of the injection liquid, and the storage time of the injection liquid is prolonged; after the polyethylene glycol-400 is adopted to conduct intramuscular injection, the blood concentration peak can be reached in short time, so that intramuscular injection is easier; and by adopting the polyvinylpyrrolidone K12, drugs are slowly released, the drug action time is prolonged, the injection interval time is prolonged, the injection dosage is decreased, and animal stress response is reduced.

Description

technical field [0001] The invention relates to a veterinary injection preparation, in particular to a veterinary long-acting oxytetracycline injection and a preparation method thereof. Background technique [0002] Oxytetracycline is a tetracycline broad-spectrum antibiotic, which not only inhibits Gram-positive bacteria and negative bacteria, but also inhibits Rickettsia, Mycoplasma, Chlamydia, Spirochetes, Actinomycetes and some protozoa. It has a strong effect on Gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, Bacillus anthracis, Clostridium tetani and Clostridium, and has a strong effect on Gram-negative bacteria such as Escherichia coli, Salmonella, Brucella and Pasteurella. Bacteria are more sensitive. Oxytetracycline injection was first developed by Pfizer Pharmaceutical Company of the United States. In 2013, the Ministry of Agriculture of my country also approved two specifications of oxytetracycline injection for animals, 10% and 20%, but t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/08A61K47/02A61K47/22A61K47/10A61K47/32A61K31/65A61P31/04A61P33/02
CPCA61K9/0019A61K9/08A61K31/65A61K47/02A61K47/08A61K47/10A61K47/22A61K47/32A61P31/04A61P33/02
Inventor 戴永德张兴元
Owner 成都新亨药业有限公司
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