Veterinary long-acting oxytetracycline injection liquid and preparation method thereof
A long-acting oxytetracycline and injection technology, which is applied in the directions of inactive medical preparations, pharmaceutical formulations, inorganic inactive ingredients, etc., can solve the problem of slow release of active pharmaceutical ingredients, reduce the production cost of farmers, and prolong the injection Storage time and other issues to achieve the effect of reducing toxic side effects, increasing drug action time, and improving storage time
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Embodiment 1
[0027] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 11 g of oxytetracycline dihydrate, 1.5 g of magnesium oxide, and 0.4 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 20g, polyvinylpyrrolidone K12 1g, polyethylene glycol-400 40g, monoethanolamine 1.2g, and the balance is water for injection.
[0028] Its preparation method is as follows: add 10ml of water for injection into a stainless steel bucket, add 0.4g of sodium formaldehyde sulfoxylate during the stirring process, and stir until completely dissolved to obtain a spare solution A; add 10ml of water for injection into the liquid preparation pot, and stir while stirring Add 20g of glycerol methylal, 40g of polyethylene glycol-400, and 1g of polyvinylpyrrolidone K12 in sequence, and stir until completely dissolved to obtain stock solution B; add stock solution A to stock solution B, stir evenly, and h...
Embodiment 2
[0030] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 22 g of oxytetracycline dihydrate, 1.7 g of magnesium oxide, and 0.5 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 30g, polyvinylpyrrolidone K12 5g, polyethylene glycol-400 20g, monoethanolamine 1.4g, and the balance is water for injection.
[0031] Its preparation method is as follows: add 15ml of water for injection into a stainless steel bucket, add 0.5g of sodium formaldehyde sulfoxylate during the stirring process, and stir until it is completely dissolved to obtain a spare solution A; add 15ml of water for injection into the liquid preparation pot, and stir while stirring Add 30g of glycerol methylal, 20g of polyethylene glycol-400, 5g of polyvinylpyrrolidone K12 in sequence, stir until completely dissolved, and obtain stock solution B; add stock solution A to stock solution B, stir well, and hea...
Embodiment 3
[0033] This embodiment provides a long-acting oxytetracycline injection for animals, which contains 22 g of oxytetracycline dihydrate, 1.7 g of magnesium oxide, and 0.5 g of sodium formaldehyde sulfoxylate per 100 ml of the long-acting oxytetracycline injection for animals , glycerol methylal 30g, polyvinylpyrrolidone K12 2g, polyethylene glycol-400 20g, monoethanolamine 1.4g, and the balance is water for injection.
[0034] Its preparation method is as follows: add 15ml of water for injection into a stainless steel bucket, add 0.5g of sodium formaldehyde sulfoxylate during the stirring process, and stir until it is completely dissolved to obtain a spare solution A; add 15ml of water for injection into the liquid preparation pot, and stir while stirring Add 30g of glycerol methylal, 20g of polyethylene glycol-400, and 2g of polyvinylpyrrolidone K12 in sequence, and stir until completely dissolved to obtain reserve solution B; add reserve solution A to reserve solution B, stir e...
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