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Veterinary pyridaben preparation for killing parasites and preparation method thereof

A technology for killing parasites and pyridaben, which is applied in the field of veterinary medicine, can solve the problems of polluting environmental water sources, large side effects of poultry and livestock, and unsuitable animals, and achieves the effects of energy saving, low toxicity, and increased penetration

Inactive Publication Date: 2018-05-22
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because the related products of pyridaben on the market, such as emulsion, are not veterinary drugs developed for animals, a large amount of organic solvents are used in their preparations. These organic solvents are highly toxic and have relatively large side effects on poultry and livestock. Cause animal discomfort, and also pollute the environment and water sources
The patent application number is 200810101134.7 Chinese patent "A water emulsion with pyridaben as active ingredient and its preparation method" and the patent application number is 200810101922.6 Chinese patent "A preparation method of pyridaben microemulsion", which are mainly aimed at It is used for crops and plants, and its solvents (xylene, toluene, dimethylformamide, etc.) and emulsifiers (33#, 34#, etc.) are mostly toxic preparations, not suitable for animals
In addition, as far as the solubility of pyridaben is concerned, only xylene or cyclohexane is more soluble and suitable as a solvent for pyridaben, while both xylene and cyclohexane are solvents with high toxicity and strong odor Not suitable for livestock and poultry use

Method used

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  • Veterinary pyridaben preparation for killing parasites and preparation method thereof
  • Veterinary pyridaben preparation for killing parasites and preparation method thereof
  • Veterinary pyridaben preparation for killing parasites and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 10% pyridaben parasite killing preparation, including the following components by mass percentage:

[0030]

[0031] Wherein the composite solvent is composed of 25% of glycerin formal, 5% of propylene glycol, 55% of dimethylacetamide, and the balance of purified water, calculated by mass percentage.

[0032] The penetration enhancer is obtained by mixing medium-chain fatty acid triglycerides and water-based azone at a mass ratio of 10:5.

[0033] Preparation method: Accurately weigh the original powder of pyridaben, add warm (45°C) composite solvent to dissolve pyridaben into a liquid, then add Tween 80 to fully stir and emulsify, mix at high speed (2000r / min) to form O / W state, then add the osmotic synergist and stir evenly, and finally add the remaining amount of purified water, and stir evenly to obtain 10% pyridaben parasite killing preparation.

[0034] After testing, the solubility of pyridaben in the composite solvent in this embodiment is about 332g / L.

Embodiment 2

[0036] 15% pyridaben microemulsion preparation, including the following mass percentage components:

[0037]

[0038] Wherein the composite solvent is composed of 25% of glycerin formal, 5% of propylene glycol, 55% of dimethylacetamide, and the balance of purified water, calculated by mass percentage.

[0039] The penetration enhancer is obtained by mixing medium-chain fatty acid triglycerides and water-based azone at a mass ratio of 10:5.

[0040] Preparation method: Accurately weigh the original powder of pyridaben, add warm (45°C) composite solvent to dissolve pyridaben into a liquid, then add Tween 80 to fully stir and emulsify, mix at high speed (2000r / min) to form In the O / W state, then add the penetration synergist and stir evenly, and finally add the remaining amount of purified water, and stir evenly to obtain 15% pyridaben parasite-killing preparation.

[0041] After testing, the solubility of pyridaben in the composite solvent in this example is about 333g / L.

Embodiment 3

[0043] 10% pyridaben killing parasite preparations, including the following mass percentage components:

[0044]

[0045] Wherein the composite solvent is composed of 25% of glycerin formal, 5% of propylene glycol, 55% of dimethylacetamide, and the balance of purified water; calculated by mass percentage.

[0046] The penetration enhancer is obtained by mixing medium-chain fatty acid triglycerides and water-based azone at a mass ratio of 10:5.

[0047] Preparation method: Accurately weigh the original powder of pyridaben, add warm (45°C) composite solvent to dissolve pyridaben into a liquid, then add Tween 80 to fully stir and emulsify, mix at high speed (2000r / min) to form O / W state, then add the osmotic synergist and stir evenly, and finally add the remaining amount of purified water, and stir evenly to obtain 10% pyridaben parasite killing preparation.

[0048] After testing, the solubility of pyridaben in the composite solvent in this example is about 331 g / L.

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PUM

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Abstract

The invention discloses a veterinary pyridaben preparation for killing parasites and a preparation method thereof, and belongs to the field of veterinary drugs. The preparation comprises following components in percentage by weight: 1 to 30% of pyridaben, 5 to 60% of composite solvent, 5 to 30% of emulsifier, 1 to 25% of osmosis synergist, and the balance being diluent, wherein the composite solvent is composed of glycerol formal, propylene glycol, dimethyl acetamide, and purified water. The preparation is made of medical grade and food grade substances with low toxicity; through compounding,pyridaben can be well dissolved, and the shortages of a conventional pyridaben preparation such as large toxicity, damage to health of animals, and the like, are solved. The preparation can be directly painted or smeared on the furs and hair of animals; the active components are diffused through the furs and hair, the in-vitro parasites are killed, and moreover, the preparation does not have any side or toxic effect, does not generate any residue, and is safe, economic and environmentally friendly.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a veterinary pyridaben parasite-killing preparation and a preparation method thereof. Background technique [0002] The chemical name of pyridaben is 2-tert-butyl-5-(4-tert-butylbenzylthio)-4-chloro-2H-pyridazin-3-one, which is a colorless crystal and belongs to the class of pyridazinone insecticides , Acaricide, no systemic absorption. Pyridaben is a low-toxic contact acaricide, which has obvious control effects on plant-eating harmful mites such as spider mites, panonychia, claw mites, and gall mites, and is effective against eggs, nymphs, and adults , It is also effective for the mobile period of adult mites. According to Wang Jianguo et al. "Observation on the curative effect of trichlorfon and pyridaben on swine scabies" (Wang Jianguo, Zhang Xianhui. Observation on the curative effect of trichlorfon and pyridaben on swine scabies[J]. Henan Animal Husbandry an...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/50A61K47/10A61K47/14A61K47/18A61K47/22A61K47/26A61P33/14
CPCA61K9/0017A61K9/1075A61K31/50A61K47/10A61K47/14A61K47/18A61K47/22A61K47/26
Inventor 刘肖娟谭志坚黎剑坤翁亚彪符德文袁增辉陈艺青
Owner FOSHAN STANDARD BIO TECH
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