Non-oily doramectin injection as well as preparation method and application thereof

A doramectin and non-oily technology, which is applied in the field of non-oily doramectin injection and its preparation, can solve the problems of easy rancidity or discoloration of oil, high difficulty of filtration sterilization, and poor application effect, so as to promote dissolution , The preparation method is simple and efficient, and the use effect is good

Active Publication Date: 2017-11-24
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oils are prone to rancidity or discoloration when exposed to light or air, resulting in poor stability
In addition, the viscosity of doramectin injection is very high, it is difficult to filter and sterilize, and it is difficult to withdraw the needle during use, and it is easy to accumulate bulges at the injection site, which will cause pain reactions, strong irritation, and poor application effect

Method used

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  • Non-oily doramectin injection as well as preparation method and application thereof
  • Non-oily doramectin injection as well as preparation method and application thereof
  • Non-oily doramectin injection as well as preparation method and application thereof

Examples

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preparation example Construction

[0036] A preparation method of the above-mentioned non-oily doramectin injection, comprising the following steps:

[0037] Take 0.1%-10% doramectin by weight percentage, and add it into a solvent mixed with glycerol formal and propylene glycol, wherein the mass ratio of the glycerol formal to the propylene glycol is (4-8): (2- 6);

[0038] The solvent and the doramectin are mixed, stirred evenly, subpackaged by blowing nitrogen, capped, sterilized, passed the light inspection and packaged to obtain the non-oily doramectin injection.

[0039] In addition, it is also necessary to provide a non-oily doramectin injection for preventing, treating or controlling parasites in animals.

[0040] The non-oily doramectin injection in the present invention can be used for deworming in vivo and in vitro of poultry, livestock and other animals. For example, the injection can be used for subcutaneous or intramuscular injection of animals for in vivo deworming, or the injection can be appli...

Embodiment 1

[0043] Weigh each raw material with the following weight percentage (take the total amount of 100ml as an example)

[0044] Doramectin 1%, glycerin formal 59.4% and propylene glycol 39.6%.

[0045] 1) Add glycerin formal and propylene glycol into the stirring tank, and mix well;

[0046] 2) Add the doramectin into the mixing tank in step 1), and stir for 15 minutes until it is completely dissolved;

[0047] 3) The solution obtained in step 2) is subpackaged by blowing nitrogen, capped, sterilized, passed the lamp inspection and packaged to obtain the non-oily doramectin injection 1.

Embodiment 2

[0049] Weigh each raw material with the following weight percentage (take the total amount of 100ml as an example)

[0050] Doramectin 1%, glycerin formal 39.7% and propylene glycol 59.3%.

[0051] The preparation method of this non-oily doramectin injection 2 is the same as that of Example 1.

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Abstract

The invention relates to non-oily doramectin injection as well as a preparation method and an application thereof. The non-oily doramectin injection is prepared from the following components: doramectin, glycerolformal and propylene glycol, wherein doramectin accounts for 0.1%-10% of the non-oily doramectin injection by weight, a mixed solvent is prepared from glycerolformal and propylene glycol, and the mass ratio of glycerolformal to propylene glycol in the mixed solvent is (4-8):(2-6). The non-oily doramectin injection is good in stability and low in irritation.

Description

technical field [0001] The technical field of antiparasitic drugs of the present invention, in particular relates to a non-oily doramectin injection and its preparation method and application. Background technique [0002] Doramectin (CAS accession number is 11774-25-3) is a new generation of macrolide antiparasitic drugs, the chemical name is 25-cyclohexyl-5-0-desmethyl-25-des(1- Methylpropyl) Abamectin Ala, the chemical formula is C 50 h 74 o 14 . Compared with traditional avermectin drugs, doramectin has good pharmacokinetic characteristics, and its drug effect maintenance time is increased by 30% compared with ivermectin. Therefore, doramectin has a good market prospect as a veterinary antiparasitic drug. [0003] The insecticidal mechanism of doramectins is mainly to interfere with the neurophysiological activities of parasites, which can stimulate arthropods, nematodes and other parasites to release inhibitory neurotransmitters (such as GABA), and then paralyze an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/10A61P33/10A61P33/00
CPCA61K9/0019A61K9/08A61K31/7048A61K47/10
Inventor 李成应元晓琪付良凯孙迎江国亮
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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