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Method for determining content of glycerol formal by gas chromatography external standard method

A technology of glycerol formal and gas chromatography, which is applied in the field of gas chromatography external standard method for determining the content of glycerol formal

Inactive Publication Date: 2021-09-24
泰州骏道立同生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Check the literature, some scholars use high performance liquid chromatography to determine the two components (glycerol and formaldehyde) of glycerin formal, and some scholars use spectrophotometry to determine the content of free formaldehyde in glycerol formal, but there is no external standard method using gas chromatography. Method for Determination of Glycerol Formal Content by Instrument

Method used

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  • Method for determining content of glycerol formal by gas chromatography external standard method
  • Method for determining content of glycerol formal by gas chromatography external standard method
  • Method for determining content of glycerol formal by gas chromatography external standard method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Gas chromatography external standard method is used to determine the content of glycerin formal, and the specific method is as follows:

[0036] (1) Prepare samples and instruments:

[0037] Glycerol formal for testing was provided by Chengdu Kelong Chemical Co., Ltd., AR grade, and the batch numbers were 2019082203 and 2020042303;

[0038] Glycerin formal reference substance was provided by Shanghai Aladdin Biochemical Technology Co., Ltd., batch number G141045, with a content of 98.1%.

[0039] Mettler ESJ60-4 electronic balance, Shimadzu GC-2030 high-efficiency gas chromatograph.

[0040] (2) preparation of glycerol formal need testing solution:

[0041] a. Accurately weigh 500 mg of glycerol formal for the test, place it in a 50 mL volumetric flask, add methanol and shake to mix, set the volume to the mark, and use it as the stock solution of glycerol formal for the test;

[0042] b. Precisely measure 2.5mL of the glycerol formal test product stock solution, tran...

Embodiment 2

[0057] Method validation for the determination of glycerol formal content by gas chromatography external standard method:

[0058] 1. System suitability

[0059] According to the method of step (2) in embodiment 1, glycerol formal test sample is replaced into glycerin, formaldehyde respectively and obtains glycerol stock solution and formaldehyde stock solution;

[0060] According to the method of step (3) in embodiment 1, glycerol formal test sample is replaced into glycerin, formaldehyde respectively and obtains glycerin positioning solution and formaldehyde positioning solution;

[0061] Mixed test solution: Accurately measure 2.5mL of glycerol formal stock solution, 0.5mL of glycerol stock solution and 0.5mL of formaldehyde stock solution prepared in Example 1, pipette into a 5mL volumetric flask, add methanol and shake to mix, set To the mark, as a mixed test solution;

[0062] Precisely measure 1 μ L of glycerol formal reference substance solution, glycerol positioning...

Embodiment 3

[0096] Using the chromatographic conditions and measurement method of the present invention "determining the content of glycerol formal by gas chromatography external standard method", two batches of AR grade glycerol formal from the same manufacturer (batch numbers are 2019082203, 2020042303, and the specification is 500mL) are used for content determination. The results are as follows: Table 7 shows.

[0097] It can be seen from Table 7 that the contents of two batches of AR grade glycerol formal from the same manufacturer are 99.43% and 99.09% respectively, which is consistent with the range indicated on the label, which indirectly shows that the glycerol formal content determination method of the present invention is feasible.

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Abstract

The invention relates to a method for determining the content of glycerol formal by a gas chromatography external standard method, and belongs to the technical field of analysis and detection. The invention discloses a method for determining the content of glycerol formal by a gas chromatography external standard method, which adopts gas chromatography to qualitatively analyze the glycerol formal and adopts the external standard method to quantitatively analyze the glycerol formal, and can accurately, sensitively, simply, conveniently and quickly test the content of the glycerol formal. The vacancy of the content determination item in the existing glycerol formal quality standard is filled, and the glycerol formal can be conveniently used for preparing safer and more effective related medicinal preparations.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and relates to a method for determining the content of glycerin formal by a gas chromatography external standard method. Background technique [0002] Glycerol formal (Glycerolformal) is the product of the condensation reaction of glycerin and formaldehyde (refined by the condensation reaction of a certain amount of glycerin and formaldehyde under the action of a dehydrating agent and a catalyst), and is a colorless and transparent liquid. Glycerol formal is a commonly used medical and veterinary drug excipient, and it is a substitute for glycerin, propylene glycol and pyrrolidone. As a solvent, glycerin formal can be compatible with propylene glycol, water, glycerin, ether, acetone, refined oil, ethanol and other solvents in any proportion. It is a special solvent for ivermectin injection of American company. Since glycerol formal has almost no toxicity, no side effects, and no s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8631G01N2030/025
Inventor 罗永煌何丽杰蒲青秀
Owner 泰州骏道立同生物科技有限公司
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