Swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection and preparation method thereof

A technology for porcine epierythrocytes and long-acting oxytetracycline, which is applied in the directions of extracellular fluid diseases, medical preparations containing active ingredients, anti-inflammatory agents, etc.

Inactive Publication Date: 2011-01-26
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, under acidic conditions, long-acting sustained-release oxytetracycline suspoemulsion is not conducive to long-term stable storage

Method used

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  • Swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection and preparation method thereof
  • Swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection and preparation method thereof
  • Swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The formula of 100mL of this injection is as follows:

[0028] Oxytetracycline Hydrochloride 30g

[0029] Roxars Arsenic 3g

[0030] Acetaminophen 8g

[0031] Organic solvent (V glycerol formal: V polyethylene glycol 200 = 2:1) 50mL

[0032] Magnesium chloride 6g

[0033] Sodium formaldehyde sulfoxylate 0.6g

[0034] Polyvinylpyrrolidone K12 7.5g

[0035] Monoethanolamine 6mL

[0036] Make up to 100mL with water for injection

[0037] Specific steps:

[0038] 1) Weigh the prescribed amount of magnesium chloride, sodium formaldehyde sulfoxylate and water for injection into a liquid mixing tank that can provide anaerobic environment and temperature control by flushing nitrogen, stir evenly, and make A liquid;

[0039] 2) Weigh the prescription amount of compound organic solvent (composed of glycerol methylal and polyethylene glycol 200 in an appropriate proportion), control the temperature at 50°C-55°C, and flush into nitrogen to remove the oxygen in the liquid mi...

Embodiment 2

[0044] The formula of 100mL of this injection is as follows:

[0045] Oxytetracycline Hydrochloride 25g

[0046] Roxars Arsenic 3g

[0047] Acetaminophen 8g

[0048] Organic solvent (V glycerol formal: V polyethylene glycol 400 = 3:1) 45mL

[0049] Magnesium chloride 5g

[0050] Sodium formaldehyde sulfoxylate 0.5g

[0051] Polyvinylpyrrolidone K12 5g

[0052] Monoethanolamine 5mL

[0053] Make up to 100mL with water for injection

Embodiment 3

[0055] The formula of 100mL of this injection is as follows:

[0056] Oxytetracycline Hydrochloride 20g

[0057] Roxars Arsenic 3g

[0058] Acetaminophen 10g

[0059] Organic solvent (V glycerin formal: V dimethylacetamide 400=3:1) 40mL

[0060] Magnesium chloride 4g

[0061] Sodium formaldehyde sulfoxylate 0.4g

[0062] Polyvinylpyrrolidone K12 5g

[0063] Monoethanolamine 4mL

[0064] Make up to 100mL with water for injection

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PUM

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Abstract

The invention discloses swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection, which comprises the following components in part by mass: oxytetracycline hydrochloride (or alkaloids thereof), roxarsone, acetaminophen, glycerol formal, polyvinylpyrrolidone K12, polyvinylpyrrolidone K17, polyethylene glycol 200, polyethylene glycol 400, magnesium chloride, sodium formaldehyde sulphoxylate, monoethanol amine and water for injection. Due to the compatibility of the oxytetracycline hydrochloride (or the alkaloids thereof), the roxarsone and the acetaminophen and synergistic action of each medicament component, the injection treats both symptoms and root causes of swine eperythrozoonosis so as to fulfill the aim of quick and effective treatment.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a compound long-acting oxytetracycline injection capable of rapidly and effectively treating porcine eperythrozoonosis from two aspects of etiology and disease and a preparation method thereof. technical background [0002] Porcine Eperythrozoonosis is an infectious disease caused by Eperythrozoon porcine and small Eperythrozoon that only infects pigs. It is clinically characterized by fever, anemia and jaundice. Eperythrozoon porcine parasitizes on the surface of red blood cells, plasma and bone marrow of pigs, destroys red blood cells in the blood, deforms red blood cells, invaginates hemolysis, and loses its oxygen-carrying function, resulting in decreased resistance of pigs and easy to be infected with other diseases. As a result, piglets' physique deteriorated, anemia, intestinal and respiratory infections increased; daily gain of fattening pigs decreased, acute he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K31/285A61K31/167A61K9/08A61P31/00A61P29/00A61P7/06
Inventor 欧阳五庆刘伟李雅
Owner NORTHWEST A & F UNIV
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