Preparation method of decoquinate solution

Abstract

The invention discloses a preparation method of a decoquinate solution. The decoquinate solution comprises a solvent, a cosolvent and a pH modifier, wherein the solvent is dimethylformamide, twain, absolute ethyl alcohol, polyethylene glycol and glycerolformal. The preparation is prepared by the following steps at normal temperature and pressure: (1) stirring dimethylformamide and the cosolvent, adding decoquinate to stir and dissolve, adjusting the pH value of the mixed solution to 3.0-4.5 by virtue of the pH modifier, and stirring evenly for later use; (2) adding absolute ethyl alcohol to polyethylene glycol, heating, stirring, and adding dioxolane-4-methanol after 30 minutes, wherein the heating temperature is 70-80 DEG C; and (3) mixing the solution prepared from the step (1) with the solution prepared from the step (2) evenly, naturally cooling to room temperature, adding twain, stirring evenly, precisely filtering and bulking. The production process of the preparation method is safe; the decoquinate solution can be prepared at normal temperature and pressure; the preparation process is simple; the effect for preventing ball insect diseases of poultry is effect; and compared with other anticoccidial drugs, the cost is relatively low.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a preparation method of decoquinate solution. Background technique [0002] Decoxyquinate is white or off-white crystalline powder, slightly soluble in ethanol, insoluble in water, and can play a role in the asexual reproduction stage of coccidia. After entering the coccidian spore cells, it prevents its development by interfering with DNA synthesis. It works early in the worm's life cycle to avoid damage to the poultry gut. However, decoquinate is expensive, insoluble in water, and the cost of preparing a solid additive is relatively high, resulting in high feed cost; moreover, the drug effect has a great relationship with the particle size of the additive. Today, as the feed industry is becoming more and more meager, it is difficult to promote its use in feed. Although several factories in China have synthesized decoquinate API, its price still prevents it from bei...

AI Technical Summary

Problems solved by technology

The Chinese patent No. CN102106814A, published on June 29, 2011, discloses a new type of high-efficiency anticoccidial drug decoxyquinate solution and its preparation method, but the preparation process requires high temperature and high pressure sterilization, and the process flow is relatively cumbersome

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