Long-acting veterinary ivermectin injection and preparation method thereof

Abstract

The invention relates to long-acting veterinary ivermectin injection. Every 1000ml long-acting veterinary ivermectin injection contains 10-15g of ivermectin, 500-600ml propylene glycol, 200-300ml of absolute ethyl alcohol, 80-120ml of glycerolformal and 80-120ml of benzyl alcohol. A preparation method of the long-acting veterinary ivermectin injection comprises the following steps: 1) adding ivermectin and propylene glycol into absolute ethyl alcohol, stirring, and dissolving; and 2) adding glycerolformal and benzyl alcohol into the solution obtained in the step 1), uniformly stirring, maintaining constant volume, carrying out sterile filtration, and encapsulating, thus the long-acting veterinary ivermectin injection is obtained. The long-acting veterinary ivermectin injection is stable in quality, effect can last for 72 hours, anthelminthic effect is remarkable, insect bodies inside and outside livestock and poultry can be dispelled, and diseases like swine, bovine and ovine horned toad can be treated by only injecting the long-acting veterinary ivermectin injection once.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a long-acting ivermectin injection for animals and a preparation method thereof. Background technique [0002] Ivermectin (Ivermectin, referred to as IVM) is a novel, highly efficient, low-toxic macrolide antiparasitic drug, which is the dihydrogen reduction product of Avermectin, and is especially effective against internal and external parasites. Both nematodes and arthropods have good repellent effect, and are widely used in animal husbandry production. It is mainly used for the prevention and treatment of livestock gastrointestinal nematodes (such as roundworms, esophageal mouth nematodes, trichocephala, Strongyloides, etc.), lung nematodes, renal nodular nematodes, mites and other parasitic insects (such as spleen, blood, etc.) , lice, cowhide bot, grain bot, sheep nose bot, etc.) disease. [0003] Ivermectin is widely used clinically, and the blood drug peaks in 2-4 hours...

AI Technical Summary

Problems solved by technology

Although the ivermectin injection has been developed, due to its extremely low water solubility, different solvents are used in the preparation, so that there are different problems in product quality

Moreover, ivermectin currently only has common preparations, and the maintenance time of each administration is short, and multiple administrations are required. For example, the efficacy of ivermectin can only be maintained for about 12 hours, and it needs to be injected every seven days, and three consecutive injections can cure the disease. If it does not recur, there are disadvantages such as inconvenient use and a waste of manpower and material resources. There is an urgent need to study new products to adapt to the rapid development of animal husbandry.