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Compound closantel sodium-ivermectin injection for animal and preparation method thereof

A technology for compound cylindronate sodium and cylioxide sodium is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. The formula is cumbersome and other problems, to achieve the effect of simple preparation, reduced viscosity, low residual human and animal and the environment

Inactive Publication Date: 2006-12-13
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, abamectin, levamisole, fenbendazole, etc. have been listed as the first choice drugs for the treatment of parasitic diseases. Due to long-term repeated use, the parasites have developed tolerance to the drugs and the curative effect has been reduced; and now Some compound antiparasitic drugs have cumbersome formulas, relatively complicated preparations and expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Take 30g of glycerin formal and heat to 80°C, add 8g of abamectin and stir to dissolve, add 115g of iodosalex sodium and stir to dissolve to form a primary solution.

[0033] (2) Get 8g of phenylethyl alcohol and join in the above-mentioned primary solution, stir evenly and add 550g of propylene glycol to make a kind of veterinary compound closantamide sodium-abamectin injection.

Embodiment 2

[0035] (1) Take 40g of glycerol formal and heat to 60°C, add 10g of avermectin and stir to dissolve, add 125g of iodosalex sodium and stir to dissolve to form a primary solution.

[0036] (2) Get 9g of phenylethyl alcohol and join in the above-mentioned primary solution, stir evenly and add 570g of propylene glycol to make a kind of veterinary compound closantamide sodium-abamectin injection.

Embodiment 3

[0038] (1) Take 45g of glycerol formal and heat to 70°C, add 11g of avermectin and stir to dissolve, add 130g of iodosalex sodium and stir to dissolve, forming a primary solution.

[0039] (2) Get 11g of phenylethyl alcohol and join in the above-mentioned primary solution, stir and add 580g of propylene glycol and promptly make a kind of veterinary compound iodosalex sodium-abamectin injection.

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PUM

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Abstract

The invention relates to a Closantel sodium and avermectin compound injection for animals and process for preparation, wherein the injection is prepared from Closantel sodium, avermectin, glycerol formal, benzyl carbinol and methyl glycol as raw material through mixing homogeneously under predetermined conditions.

Description

technical field [0001] The invention relates to a veterinary antiparasitic drug, in particular to a veterinary compound closamide sodium-abamectin injection and a preparation method thereof. Background technique [0002] Parasitic diseases are one of the most common diseases in animals. In mild cases, parasitic diseases lead to slow growth of animals and reduced feed utilization; in severe cases, they lead to animal malnutrition, reduced quality, and even a significant increase in mortality due to low animal disease resistance . For decades, abamectin, levamisole, fenbendazole, etc. have been listed as the first choice drugs for the treatment of parasitic diseases. Due to long-term repeated use, the parasites have developed tolerance to the drugs and the curative effect has been reduced; and now Some compound antiparasitic drugs have cumbersome formulations, relatively complicated preparations and expensive prices. [0003] Closantamide sodium and abamectin are commonly us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61K31/275A61K47/10A61K47/08A61P33/00
Inventor 魏宗生耿强斌
Owner TIANJIN SHENGJI GRP CO LTD
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