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102 results about "Treatment side effects" patented technology

Side effects (treatment) includes the side effects arising from all treatment but drug therapy which is covered in the article Side effects (drug) Surgery, of course, may have a number of undesirable or harmful after effects, such as infection, hemorrhage, inflammation, scarring, loss of function, changes in local blood flow, and so on.

Chimeric antigen receptor and expression gene thereof, double-antigen regulated type T cell modified by chimeric antigen receptor, and application thereof

The invention relates to a chimeric antigen receptor and an expression gene thereof, a double-antigen regulated type T cell modified by the chimeric antigen receptor, and application thereof. The expression gene of the chimeric antigen receptor comprises a first fusion protein expression gene and a second fusion protein expression gene, wherein the first fusion protein expression gene comprises a mucoprotein-1 antibody expression gene, a notch receptor expression gene and a Gal4-VP64 transcription activating protein expression gene which are sequentially connected; the second fusion protein expression gene comprises a Gal4-UAS promoter expression gene and an anti-mesothelin expression gene which are sequentially connected. By adopting the innovative design, the chimeric antigen receptor has the advantages that the chimeric antigen receptor can be successfully imported into the T cell to form the T cell modified by the chimeric antigen receptor; the immune reaction cannot be produced until the mucoprotein-1 and the anti-mesothelin signals simultaneously exist, so as to reach the controllable immune reaction of the chimeric antigen receptor, fewer side effects in treatment, and high specificity.
Owner:深圳华云生物技术有限公司
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