20 results about "Treatment side effects" patented technology

Embodiments are directed to a new imaging modality called X-ray-induced acoustic computed tomography (XACT) technology and can be combined with traditional pulse and echo ultrasound imaging. It has the capability of real-time monitoring of geometric and morphological misalignments of the X-ray field with respect to the target tissue, thus improving radiotherapy tumor eradication and limiting treatment side effects. The XACT / US image-guided radiotherapy system according to embodiments holds great potential for personalized cancer treatment and better outcomes.

The invention discloses a multi-frequency cancer cell cleaning cabin for cancer patients and application, and relates to the field of cancer treatment equipment. The cleaning cabin comprises a cabin main body, a multi-frequency generation module, a targeted positioning module, a temperature control module, a monitoring module and a central control unit, an adjustable lying platform and an electromagnetic shielding layer are arranged in the cabin main body, the multi-frequency generation module comprises three independent frequency generators and a directional radiation antenna, and the targeted positioning module positions cancer cells through an infrared thermal imaging assembly and an ultrasonic imaging assembly. Cancer cell information is obtained through targeted positioning, the central control unit regulates and controls the multi-frequency generation module to output adaptive frequency, and low-damage cleaning of cancer cells of different depths is achieved in combination with temperature control and real-time monitoring. The traditional Chinese medicine composition solves the problems of large side effect and narrow application range in the existing treatment, has the advantages of small side effect, wide application range, safety and controllability, and is suitable for postoperative residue removal of cancers and middle and advanced palliation treatment.

The invention discloses a composition for regulating overall metabolic balance, inhibiting cancer cell growth and resisting tumors. The composition comprises the following raw materials: lucid ganoderma, crocodile peptide, astragalus membranaceus, anoectochilus formosanus, ginseng, turmeric, clove, poria cocos, golden camellia, glutathione-rich yeast, cordyceps militaris, endothelium corneum gigeriae galli, peach kernels, compound probiotics and cardamine violifolia. According to the invention, the modern medical science concept and the theory of'caking caused by blood stasis and qi stagnation 'in the traditional Chinese medicine are fused, the raw materials have a synergistic effect, and mitochondria is protected from being damaged and mutated through the ways of increasing the blood oxygen content, resisting inflammation, improving the metabolic function, promoting blood circulation to remove blood stasis and the like; by means of supplementing composite probiotics and the like, intestinal flora is conditioned, immunity is enhanced, finally, the purposes of softening hardness to dissipate stagnation, adjusting overall metabolic balance, inhibiting cancer cell growth, resisting tumors and relieving tumor treatment side effects are achieved, and the application prospect is wide.

The application discloses a kind of composition of adjusting overall metabolic balance, inhibiting cancer cell growth, antitumor, raw material includes ganoderma lucidum, crocodile peptide, astragalus, polypodium pinnatum, ginseng, turmeric, clove, poria cocos, camellia sinensis, rich glutathione yeast, cordyceps militaris, gizzard gold, peach kernel, compound probiotics, brassica campestris l.var.rapa.The application fuses modern medical scientific concept and traditional Chinese medicine "blood stasis and stagnation and cause mass" theory, raw material synergistic effect, by improving blood oxygen content, anti-inflammatory, improve metabolic function, blood circulation and other ways, realize protection mitochondria from damage, anti-mutation;And through the way such as supplementing compound probiotics, regulate intestinal flora, enhance immunity, finally realize soft and hard knot, adjust overall metabolic balance, inhibit cancer cell growth, antitumor, relieve tumor treatment side effect, application prospect is wide.

The disclosure, in one aspect, relates to methods for treating cancer in a subject, the methods including at least the steps of administering at least one drug from each of at least two classes selected from an inhibitor of poly-ADP ribose polymerase (PARP inhibitor), an inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs inhibitor), an inhibitor of wild-type isocitrate dehydrogenase (IDH inhibitor), an inhibitor of histone acetyltransferase (HAT inhibitor), an inhibitor of histone deacetylase (HDAC inhibitor), an inhibitor of DNA polymerase Θ (POLΘ inhibitor), an inhibitor of platelet-derived growth factor receptor (PDGFR inhibitor), and a DNA alkylating agent to the subject. In any of these aspects, the disclosed method allows for administering lower doses of the drugs in combination compared to administration as single drugs while preventing the recurrence of the cancer, preventing drug resistance of the cancer, and reducing side effects associated with cancer treatment.

A system for monitoring organ health during treatment for cancer and the like that utilizes physiological imaging of the type used for treatment monitoring and organ-specific processing to provide a comprehensive assessment of treatment side effects.

The invention discloses an electroacupuncture and PNF collaborative ACLR afterbrain limb integrated precise rehabilitation method and system, and relates to the technical field of clinical medicine rehabilitation treatment, and the method comprises the steps: S1, baseline function and iconography evaluation; s2, preparing center modulation; s3, peripheral motion driving is carried out; s4, quantitative acquisition and response evaluation; s5, performing parameter adjustment and periodic execution; according to the invention, quantified physiological and functional indexes are embedded as a closed-loop adjustment basis, so that the electroacupuncture parameters and PNF strength of each treatment can be optimized in a data-driven manner. Through periodical evaluation of clinical knee joint function scores, balance parameters, SEMG and central function activation and adjustment and intervention according to preset rules, the method realizes transformation from empirical rehabilitation to evidence-driven and individualized rehabilitation. According to the closed-loop design, benefits of individuals on intervention can be amplified, and adverse reactions or overload risks can be recognized in real time, so that the possibility of treatment side effects or function degradation is reduced.

A biomarker composition for diagnosing side effects upon radiation exposure to the lower abdomen according to an embodiment of the present invention is composed of 12 types of blood metabolites that change upon radiation exposure to a local radiation site, wherein the blood metabolites are obtained from a radiotherapy model for prostate cancer patients, diarrhea is diagnosed as a side effect of radiation upon local radiation exposure to the lower abdomen, substances that increase at least 1.5 fold among the blood metabolites are cinnamaldehyde, oleamide, guanidinosuccinic acid, or 2-tridecanone, and substances that decrease at least 2.0 fold among the blood metabolites are isatin, acetylcarnitine, 1-(1-ethyl-1H-pyrrol-2-yl)ethanone, 1-methylhistamine, ecgonine, hexanoylglycine, boschniakine, or 4-phenylpyridine.

The invention discloses a rumen ball strain and application thereof, belongs to the technical field of biology, and aims to solve the problems of side effects of antibiotic treatment, limitation of total fecal fungus transplantation and the limitation of insufficiency of probiotics in treatment of sepsis-related lung injury in the existing detection technology. The invention provides a ruminococcus sp. Strain Rum-307, which is separated from excrement of healthy people, has a unique gene sequence, and can be rapidly colonized after antibiotic treatment, reduce intestinal permeability and prevent endotoxin transfer; by regulating CD4 + T cell subtypes, the level of proinflammatory factors (TNF-alpha and IL-6) is reduced, the anti-inflammatory factor (IL-10) is improved, and immune balance is achieved. In a CLP sepsis model, the Rum-307 can significantly improve the wet / dry ratio, the pathological score and the survival rate of the lung. The strain Rum 307 can be prepared into capsules, oral liquid and other dosage forms, is easy to produce, is suitable for treating sepsis, acute respiratory distress syndrome, intestinal sepsis and other diseases, and has remarkable clinical and commercial prospects.

The disclosure, in one aspect, relates to methods for treating cancer in a subject, the methods including at least the steps of administering at least one drug from each of at least two classes selected from an inhibitor of poly-ADP ribose polymerase (PARP inhibitor), an inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs inhibitor), an inhibitor of wild-type isocitrate dehydrogenase (IDH inhibitor), an inhibitor of histone acetyltransferase (HAT inhibitor), an inhibitor of histone deacetylase (HDAC inhibitor), an inhibitor of DNA polymerase Θ (POLΘ inhibitor), an inhibitor of platelet-derived growth factor receptor (PDGFR inhibitor), and a DNA alkylating agent to the subject. In any of these aspects, the disclosed method allows for administering lower doses of the drugs in combination compared to administration as single drugs while preventing the recurrence of the cancer, preventing drug resistance of the cancer, and reducing side effects associated with cancer treatment.

The invention relates to a combination therapy of glucocorticoid and ginsenoside. The present invention relates to a ginsenoside formulation comprising a PPT-type ginsenoside at least partially integrated in a micelle, preferably at least partially integrated in the outer layer of the micelle, said micelle having a molecular weight of at least 10,000 Da, and to ginsenoside for use in a method for preventing or treating side effects of a glucocorticoid (GC) treatment, the methods comprise administering ginsenoside to a subject suffering from or at risk of suffering from one or more GC treatment side effects. The present invention also relates to a combination of glucocorticoid (GC) and ginsenoside for use in a method of preventing or treating inflammatory diseases, wherein the method comprises administering GC and PPT ginsenoside in specific molar ratios.

The invention discloses a traditional Chinese medicine composition for treating asthma in a non-acute attack stage and a preparation method thereof, and belongs to the field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cassia twig, poria cocos, peach kernel, radix paeoniae rubra, moutan bark, ginger, Chinese date, honey-fried licorice root, magnolia flower and cocklebur fruit. According to the traditional Chinese medicine composition, traditional Chinese medicine differentiation and a modern pathological mechanism are combined, a treatment scheme which is accurate in formula, clear in mechanism, exact in curative effect and high in safety is provided, and multi-target intervention is carried out aiming at the complex pathological state of the lung deficiency fluid retention and blood stasis syndrome in the non-acute attack period of asthma; the problems that existing traditional Chinese medicine compound syndromes are incomplete in coverage, western medicine treatment is large in side effect, single in mechanism and the like are effectively solved, and a new choice is provided for clinical treatment of the asthma in the non-acute attack stage (the syndrome of lung deficiency, fluid retention and blood stasis).

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic cerebral circulation insufficiency. The traditional Chinese medicine composition comprises the following components: gastrodia elata, desert cistanche, lucid ganoderma, fructus broussonetiae, fructus lycii, rhodiola rosea, semen cuscutae, tribulus terrestris, pseudo-ginseng and motherwort fruit. The traditional Chinese medicine composition can effectively solve the problems of large side effects and limited curative effects of existing western medicine treatment, adopts natural traditional Chinese medicine components, does not have obvious toxic or side effects, can realize consideration of both symptoms and root causes from the pathogenesis of'deficiency in root and excess in superficies', avoids the problems of gastrointestinal tract injury, liver and kidney function injury and the like caused by long-term administration of western medicine, has a more lasting curative effect and is not easy to relapse; the problems that an existing traditional Chinese medicine formula is single and poor in synergistic effect are solved, the limitation of single blood circulation promoting and blood stasis removing is broken through, a multi-target-point formula system is constructed through kidney tonifying, essence replenishing, blood circulation promoting and blood stasis removing, qi tonifying, nerve soothing, liver calming and collateral dredging, all the components achieve the synergistic effect, the disease pathogenesis is comprehensively matched, and the medicine effect is stable and remarkable.

The application discloses a multimodal magnetic resonance visualization tremor treatment target positioning method and device and a UDP image acquisition method. The multimodal magnetic resonance visualization tremor treatment target positioning method comprises the following steps: acquiring a preoperative UDP image of a patient to be positioned; acquiring a preoperative UDN image of the patient to be positioned; acquiring a postoperative best lesion location heat map LS of the patient to be positioned; generating a superimposed display image according to the preoperative UDP image of the patient to be positioned and the preoperative UDN image of the patient to be positioned; superimposing the postoperative best lesion location heat map LS of the patient to be positioned in the superimposed display image, so as to acquire a final view. The application can enhance the clear boundary of a treatment target and an axial position pyramidal tract and a medial lemniscus structure, and facilitate accurate delineation of a temperature monitoring volume (Temperature Monitoring Volume) to avoid treatment side effects.

The application discloses a cancer patient psychological health evaluation and intervention method and system, and the method comprises the following steps: acquiring community interaction behavior data and clinical diagnosis and treatment characteristic data of a target user on a platform; performing natural language processing and voice emotion recognition on the community interaction behavior data, and extracting original emotion characteristics; generating a current physiological state baseline and a treatment side effect expected window of the target user based on the clinical diagnosis and treatment characteristic data; inputting the original emotion characteristics into a joint analysis model, weighting and correcting original emotion characteristic values by using the physiological state baseline and the treatment side effect expected window, and calculating a psychological health index; comparing the dynamic psychological health index with a preset risk threshold, determining a psychological health risk level of the user, and triggering a corresponding grading intervention mechanism. The application can accurately distinguish between physiological distress and pathological depression, and realizes dynamic monitoring and accurate management of the psychological state of a cancer patient in an off-hospital rehabilitation period.

The present invention relates to a composition for always resisting side effects in an anti-cancer treatment, which contains a Galium aparine extract or a graded product thereof as an active ingredient, and which has an excellent effect of preventing, improving or treating side effects in an anti-cancer treatment. The present invention relates to a pharmaceutical product, a food product or a cosmetic product which can be advantageously used for the purpose of inhibiting side effects of an anti-cancer treatment, including: for example, oxidative stress; immune decline or immunomodulatory abnormality; digestive tract injuries such as vomiting, diarrhea, gastrorrhagia or gastric ulcer; skin injuries such as skin redness, edema, blister, dermatitis, xerosis, keratinization or pigmentation, etc.

The invention relates to a nutritional composition for preventing and / or treating cancerous cachexia, and belongs to the technical field of biology. The invention provides a nutritional composition for preventing and / or treating cancerous cachexia. The composition comprises the following components: maltodextrin, solid corn syrup, fructo-oligosaccharide, galactooligosaccharide, whey protein, arginine, glutamine, fish oil, medium chain triglyceride, sunflower seed oil, linseed oil, compound macro minerals, compound vitamins and compound trace minerals. The composition not only can effectively improve adverse reactions caused by treatment, but also can comprehensively supplement key nutrients required for improving skeletal muscle states of tumor patients and promoting immune repair, accurately makes up for nutrition loss caused by disease consumption and treatment side effects of the tumor patients, relieves metabolic disorder and skeletal muscle consumption, and improves the curative effect of the tumor patients. The traditional Chinese medicine composition can improve physiological and immune functions of the body, relieve fatigue, anorexia and other symptoms, reduce the level of proinflammatory cytokines, improve body vitality and reduce the risk of treatment interruption.

The invention discloses a cancer patient psychological health assessment and intervention method and system. The method comprises the following steps: acquiring community interaction behavior data and clinical diagnosis and treatment feature data of a target user on a platform; performing natural language processing and voice emotion recognition on the community interaction behavior data, and extracting original emotion features; based on the clinical diagnosis and treatment feature data, generating a current physiological status baseline and a treatment side effect expected window of the target user; inputting the original emotional characteristics into a conjoint analysis model, performing weighted correction on the original emotional characteristics by using a physiological state baseline and a treatment side effect expectation window, and performing calculation to obtain a mental health index; and comparing the dynamic mental health index with a preset risk threshold, determining a mental health risk level of the user, and triggering a corresponding hierarchical intervention mechanism. Physiological pain and pathological depression can be accurately distinguished, and dynamic monitoring and accurate management of the psychological state of a cancer patient in the out-of-hospital rehabilitation period are achieved.

The invention relates to the technical field of medical instruments, in particular to a hematopoietic stem cell transplantation patient pressure management device and system based on laughter-induced interactive equipment, comprising a massage chair, a backrest is mounted in the massage chair, baffles are mounted on the left and right sides of the massage chair, an interaction mechanism is arranged on the outer side of the backrest, and the interaction mechanism is arranged on the outer side of the backrest. A detection assembly is arranged on the outer side of the baffle. Through arrangement of the interaction mechanism, combination with the massage chair and cooperation of the height adjusting assembly, the distance adjusting assembly and the angle adjusting assembly, the touch display screen is adjusted to the position comfortable for a patient, the comfort of the patient is improved, audiovisual content can be provided through the touch display screen, and a laughter mode can be selected according to preference; the method is suitable for children patients, a cartoonized interface and gamification interaction are designed, the attention of the patients on treatment side effects and isolation environment is transferred through interesting interaction, anxiety and depression scale scores are remarkably reduced, and treatment compliance is improved.

The disclosure, in one aspect, relates to methods for treating cancer in a subject, the methods including at least the steps of administering at least one drug from each of at least two classes selected from an inhibitor of poly-ADP ribose polymerase (PARP inhibitor), an inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs inhibitor), an inhibitor of wild-type isocitrate dehydrogenase (IDH inhibitor), an inhibitor of histone acetyltransferase (HAT inhibitor), an inhibitor of histone deacetylase (HDAC inhibitor), an inhibitor of DNA polymerase Θ (POLΘ inhibitor), an inhibitor of platelet-derived growth factor receptor (PDGFR inhibitor), and a DNA alkylating agent to the subject. In any of these aspects, the disclosed method allows for administering lower doses of the drugs in combination compared to administration as single drugs while preventing the recurrence of the cancer, preventing drug resistance of the cancer, and reducing side effects associated with cancer treatment.