35 results about "Pentacyclic triterpenoids" patented technology

The invention relates to an extraction method of lupin alkane type pentacyclic triterpenoids in the leaves of Schefflera octophylla (Lour.) Harms through ionic liquid extraction. The method comprisesthe following steps: mixing the dried Schefflera octophylla (Lour.) Harms leaf powder with extractant; carrying out ultrasonic extraction at room temperature; centrifugalizing to obtain supernatant liquid after the ultrasonic extraction is finished; taking the supernatant so that the triterpenoids is obtained. The extractant consists of ionic liquid ([BMIM] BF4, [BMIM] Br, [BMIM] PF6 or [HMIM] PF6) and 70 percent of ethanol. The experiments prove that the total content of compound A (3 alpha-hydroxy-lup-20(29)-alkene-23,28-diacid) and compound B (3 alpha- hydroxy-lup-20(29)-alkene-23,28-diacid28-0-alpha-L-rhamnosyl-(1->4)-o-beta-D-glucose-(1->6)-beta-D-glucoside) was 288.03 mg / g (n=6). Compared with the traditional extraction method, the total extraction rate of the two compounds in the leaves of Schefflera octophylla (Lour.) Harms after the addition of ion liquid can reach 28.80%.

The invention relates to an anti-fatigue chewing gum containing bamboo rutabaga extract. Its main components and weight percent content are: 40%-55% of gum base; 5%-10% of pentacyclic triterpenoids extracted from Zhuru; 30%-40% of powdered sugar; 4%-6% of glycerin; glucose pulp 3%-6%; peppermint oil 0.5%-1%. The formula of the chewing gum is scientific and reasonable. It not only has the attributes and taste of ordinary chewing gum, but also has anti-fatigue effect because of the extract of bamboo rutabaga. It stays in the oral cavity for a longer time, making it easier for people to absorb, and the health care effect is more obvious.

Disclosed are a pentacyclic triterpene compound represented by general formula (I) and pharmaceutical compositions containing the compound. Also disclosed is use of the compound in preparation of a PS1 / BACE1 interaction inhibitor, and uses thereof in preparation of drugs for treating Alzheimer's disease. Disclosed for the first time is that a pentacyclic triterpene compound represented by general formula (I) can be used as a PS1 / BACE1 inhibitor, having activity of inhibiting PS1 / BACE1 interaction, and can reduce generation of Aβ and be used in preparation of drugs for treating Alzheimer's disease.

The invention relates to novel gypsophila elegans oleanane type pentacyclic triterpenoids represented by structure formulae (I, II, III and IV). The invention further relates to a pharmaceutical composition containing the components serving as active components, and application of the compounds and the pharmaceutical composition in medicines for treating gastric adenocarcinoma and adenocarcinoma of the lung. The structure formulae are shown in the specification.

The invention discloses a metformin / ursolic acid nanometer oral preparation and a preparation method thereof, which uses self-assembly nanotechnology to self-assemble metformin and pentacyclic triterpenoid natural product ursolic acid into a particle size of 180-220 nm left and right nanoparticles, and together with the main auxiliary materials, additional auxiliary materials, and stabilizers to make nano oral preparations, the nano oral preparations obtained in the present invention have the effect of sustained release, and can reduce the side effects caused by common oral metformin hydrochloride preparations.

The present invention relates to a pentacyclic triterpenoid compound represented by general formula (I) and a preparation method thereof, a pharmaceutical composition containing the compound, the application of the compound in the preparation of a drug for treating type 2 diabetes, and the The application of said compound in the treatment of type 2 diabetes.

The invention discloses a method for preparing a non-pollution feed additive containing active ingredients of apricot leaves. In the invention, the apricot leaves are used as raw materials, cell walls of the apricot leaves are decomposed by adopting the method of Yeast fermentation, and then the active ingredients and nutritive matters in cells are completely released, thereby greatly increasing the types and the contents of the active ingredients of the apricot leaves in feed additive finished products, and removing poison materials (prussiate) at the same time. By adopting the method, the prepared non-pollution feed additive containing the active ingredients of the apricot leaves does not contain any chemical composition and toxic matters, is safe and environment-friendly, has high levels of the contents of pentacyclic triterpenoids, flavone, dietary fiber and protein, and is a novel, green and efficient.

The invention provides a method for detecting pentacyclic triterpenoids by using APCI as an ion source and using LC / MS. The method does not need to be derivatized and can detect three isomers within 6 minutes ,high sensitivity.

The invention relates to an application of an oleanane-type pentacyclic triterpene compound in preventing and treating bacterial diseases of agricultural crops and a method for preventing and treating bacterial diseases of agricultural crops using the oleanane-type pentacyclic triterpene compound. The present invention does not utilize the direct bacteriostasis of oleane-type pentacyclic triterpenoids, but improves the resistance of crops to bacterial diseases by soaking seeds before sowing or soaking roots before transplanting or spraying leaves after transplanting ability, and ultimately achieve the purpose of disease resistance. More importantly, the prevention and control method provided by the present invention only needs to be used once before planting to achieve the purpose of alleviating bacterial diseases, which greatly reduces the control cost of conventional pesticides.

The invention provides a pentacyclic triterpene compound and its application as an inhibitor of human intestinal carboxylesterase, belonging to the technical field of biomedicine. The pentacyclic triterpenoids have a 11-deoxy-glycyrrhetinic acid skeleton structure, which can potently and selectively inhibit the activity of human intestinal carboxylesterase subtype 2, thereby improving the bioavailability of oral prodrugs , and reduce the intake of intestinal esters. In addition, the inhibitor can also slow down the delayed diarrhea caused by irinotecan. In vitro activity assays found that the IC50 of this type of compound inhibiting human carboxylesterase 2 can reach 0.02 micromolar, and the ratio of the IC50 of inhibiting human carboxylesterase 1 to the IC50 of inhibiting human carboxylesterase 2 can reach 1020, and this type of compound The safety is good, and it also has the advantages of simple preparation process and high yield, suggesting that this type of compound has a good application prospect.

The present invention relates to a pharmaceutical composition, which comprises two components, the first component is selected from forskolin, isofaskolin or pharmaceutically acceptable salts thereof; the second component is selected from five Cyclic triterpenoids or pharmaceutically acceptable salts thereof. The pharmaceutical composition of the present invention uses forskolin / iforeskolin and pentacyclic triterpenoids in combination, compared with using the two components alone, it can prevent and treat metabolic, fibrosis, and liver diseases It has a significant synergistic effect, so it has broad medicinal prospects in the treatment, prevention, and improvement of diseases such as obesity, non-alcoholic fatty liver, liver injury, and liver fibrosis.

The invention relates to the application of an oleanane-type pentacyclic triterpene compound in preventing and treating fungal diseases of crops and a method for using the same to prevent and control fungal diseases of crops. The present invention does not utilize the direct antibacterial effect of oleanane-type pentacyclic triterpenes, but improves the resistance of crops to fungal diseases by soaking seeds before sowing or soaking roots before transplanting or spraying leaves after transplanting ability, and finally achieve the purpose of disease resistance. More importantly, the prevention and control method provided by the invention only needs to be applied once before planting to achieve the purpose of alleviating the disease, which greatly reduces the control cost of conventional pesticides.

The invention belongs to the field of pharmacy of traditional Chinese medicines, relating to an extract of effective parts of total saponins in pterocephalus hookeri as well as a preparation method and application thereof. By taking the content of the total saponins in the pterocephalus hookeri as an index, the extract of the total saponins in the pterocephalus hookeri provided by the invention has the characteristics of high content of the total saponins, controllable and stable quality and obvious drug effect. The main component of the extract is oleanane type pentacyclic triterpene saponins, and the content of the total saponins is 50%-90%. The preparation method provided by the invention is economical and simple in extraction technique and is applicable to industrial production. The obtained extract has obvious function of restraining the tumor cell proliferation, and can be applied in preparation of anti-tumor drugs.

The invention discloses an application of phthalic acid in hair growth promotion. The phthalic acid can be used as a unique active component for preparing a medicine or a reagent for promoting hair growth. The phthalic acid is an oleanolic acid derivative and belongs to a pentacyclic triterpenoid derivative, experiments prove that the phthalic acid group has a promoting effect on mouse hair growth, and hair growth is rapid; the invention provides a new application of the phthalic acid in promoting hair growth, and active ingredients of the phthalic acid are high in safety and small in toxic and side effects, so that the phthalic acid has a wide application prospect in the fields of pharmaceutical preparations, cosmetics, care products, beauty products and the like for preventing, nursing and treating less hair and alopecia and promoting hair health and growth.

Provided are a caffeoyl substituted pentacyclic triterpene derivative as represented by formula (I) and pharmaceutical composition containing the same. Also provided are uses of the derivative in the preparation of drugs or health-care products for preventing and treating brain injury induced by cerebral ischemia, glucose deprivation, and cerebral anoxia, and / or nervous dysfunction, and / or cognitive dysfunction.