36 results about "Pentacyclic triterpenoids" patented technology

The invention relates to an anti-fatigue chewing gum containing bamboo rutabaga extract. Its main components and weight percent content are: 40%-55% of gum base; 5%-10% of pentacyclic triterpenoids extracted from Zhuru; 30%-40% of powdered sugar; 4%-6% of glycerin; glucose pulp 3%-6%; peppermint oil 0.5%-1%. The formula of the chewing gum is scientific and reasonable. It not only has the attributes and taste of ordinary chewing gum, but also has anti-fatigue effect because of the extract of bamboo rutabaga. It stays in the oral cavity for a longer time, making it easier for people to absorb, and the health care effect is more obvious.

Disclosed are a pentacyclic triterpene compound represented by general formula (I) and pharmaceutical compositions containing the compound. Also disclosed is use of the compound in preparation of a PS1 / BACE1 interaction inhibitor, and uses thereof in preparation of drugs for treating Alzheimer's disease. Disclosed for the first time is that a pentacyclic triterpene compound represented by general formula (I) can be used as a PS1 / BACE1 inhibitor, having activity of inhibiting PS1 / BACE1 interaction, and can reduce generation of Aβ and be used in preparation of drugs for treating Alzheimer's disease.

The invention relates to novel gypsophila elegans oleanane type pentacyclic triterpenoids represented by structure formulae (I, II, III and IV). The invention further relates to a pharmaceutical composition containing the components serving as active components, and application of the compounds and the pharmaceutical composition in medicines for treating gastric adenocarcinoma and adenocarcinoma of the lung. The structure formulae are shown in the specification.

The invention discloses a metformin / ursolic acid nanometer oral preparation and a preparation method thereof, which uses self-assembly nanotechnology to self-assemble metformin and pentacyclic triterpenoid natural product ursolic acid into a particle size of 180-220 nm left and right nanoparticles, and together with the main auxiliary materials, additional auxiliary materials, and stabilizers to make nano oral preparations, the nano oral preparations obtained in the present invention have the effect of sustained release, and can reduce the side effects caused by common oral metformin hydrochloride preparations.

The invention discloses a method for preparing a non-pollution feed additive containing active ingredients of apricot leaves. In the invention, the apricot leaves are used as raw materials, cell walls of the apricot leaves are decomposed by adopting the method of Yeast fermentation, and then the active ingredients and nutritive matters in cells are completely released, thereby greatly increasing the types and the contents of the active ingredients of the apricot leaves in feed additive finished products, and removing poison materials (prussiate) at the same time. By adopting the method, the prepared non-pollution feed additive containing the active ingredients of the apricot leaves does not contain any chemical composition and toxic matters, is safe and environment-friendly, has high levels of the contents of pentacyclic triterpenoids, flavone, dietary fiber and protein, and is a novel, green and efficient.

The invention provides a pentacyclic triterpene compound and its application as an inhibitor of human intestinal carboxylesterase, belonging to the technical field of biomedicine. The pentacyclic triterpenoids have a 11-deoxy-glycyrrhetinic acid skeleton structure, which can potently and selectively inhibit the activity of human intestinal carboxylesterase subtype 2, thereby improving the bioavailability of oral prodrugs , and reduce the intake of intestinal esters. In addition, the inhibitor can also slow down the delayed diarrhea caused by irinotecan. In vitro activity assays found that the IC50 of this type of compound inhibiting human carboxylesterase 2 can reach 0.02 micromolar, and the ratio of the IC50 of inhibiting human carboxylesterase 1 to the IC50 of inhibiting human carboxylesterase 2 can reach 1020, and this type of compound The safety is good, and it also has the advantages of simple preparation process and high yield, suggesting that this type of compound has a good application prospect.

The present invention relates to a pharmaceutical composition, which comprises two components, the first component is selected from forskolin, isofaskolin or pharmaceutically acceptable salts thereof; the second component is selected from five Cyclic triterpenoids or pharmaceutically acceptable salts thereof. The pharmaceutical composition of the present invention uses forskolin / iforeskolin and pentacyclic triterpenoids in combination, compared with using the two components alone, it can prevent and treat metabolic, fibrosis, and liver diseases It has a significant synergistic effect, so it has broad medicinal prospects in the treatment, prevention, and improvement of diseases such as obesity, non-alcoholic fatty liver, liver injury, and liver fibrosis.

The invention belongs to the field of pharmacy of traditional Chinese medicines, relating to an extract of effective parts of total saponins in pterocephalus hookeri as well as a preparation method and application thereof. By taking the content of the total saponins in the pterocephalus hookeri as an index, the extract of the total saponins in the pterocephalus hookeri provided by the invention has the characteristics of high content of the total saponins, controllable and stable quality and obvious drug effect. The main component of the extract is oleanane type pentacyclic triterpene saponins, and the content of the total saponins is 50%-90%. The preparation method provided by the invention is economical and simple in extraction technique and is applicable to industrial production. The obtained extract has obvious function of restraining the tumor cell proliferation, and can be applied in preparation of anti-tumor drugs.