Gold nanorod-polymer composite injectable hydrogel and its preparation method and application

A technology of gold nanorods and polymers, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of being unsuitable for industrial production, poor targeting of cancer cells, and inability to release, etc., and is conducive to large-scale batch production , Satisfying the effect of safe and long-term use and reducing side effects

Active Publication Date: 2022-06-24
NANJING UNIV OF POSTS & TELECOMM
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Problems solved by technology

[0003] At present, conventional drug carrier materials have the following disadvantages: poor targeting of cancer cells, unable to release in time at the lesion site; unstable structure, low drug loading capacity; poor biocompatibility; not suitable for industrial production, etc.
On the other hand, the single drug loading and single functionalization of the drug delivery system can no longer meet the treatment needs of complex diseases in the future

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  • Gold nanorod-polymer composite injectable hydrogel and its preparation method and application
  • Gold nanorod-polymer composite injectable hydrogel and its preparation method and application
  • Gold nanorod-polymer composite injectable hydrogel and its preparation method and application

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[0049] The technical solution of the present invention is further described in detail below in conjunction with the accompanying drawings: the present embodiment is implemented on the premise of the technical solution of the present invention, and provides a detailed implementation manner and a specific operation process, but the protection authority of the present invention does not Limited to the following examples.

[0050] The present invention proposes a gold nanorod-polymer composite injectable hydrogel, which comprises DOX-loaded nanoparticles and photothermal conversion nanomaterial gold nanorods (AuNRs) and polymer materials. The doxorubicin (DOX)-loaded nanoparticles and AuNRs are buried in the polymer material. co - The phenylboronic acid groups on the surface of polyethylene glycol methyl ether methacrylate react, and the hydrogel is a polymer vinylbenzene boronic acid- co -Phenylboronic acid groups and polymer 3-methacrylamido dopamine on the surface of polyethyl...

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Abstract

The present invention proposes a gold nanorod-polymer composite injectable hydrogel, the gold nanorod-polymer composite injectable hydrogel is a block copolymer doped with drug-loaded nanoparticles and photothermal materials formed by reacting in an alkaline aqueous solution; the block copolymer comprises poly(3-methacrylamido dopamine- co ‑polyethylene glycol methyl ether methacrylate) and poly(vinylphenylboronic acid‑ co ‑polyethylene glycol methyl ether methacrylate). The hydrogel drug delivery system provided by the invention has the advantages of simple design, convenient operation and low cost, and is favorable for large-scale batch production.

Description

technical field [0001] The invention relates to a gold nanorod-polymer composite injectable hydrogel, a preparation method and application thereof, and belongs to the technical field of polymer biological materials. Background technique [0002] Since the 21st century, cancer has posed a huge threat to human health and life in both developed and developing countries. Currently, chemotherapy (chemotherapy) is one of the main methods used for cancer treatment worldwide. However, chemotherapy has disadvantages such as large cytotoxic side effects and low drug utilization rate. Therefore, researchers have carried out extensive research on drug carrier materials to overcome the shortcomings of traditional chemotherapy methods, reduce toxic side effects, and improve therapeutic effects. According to reports, Professor Jiao Tifeng's research group and Yan Xuehai's research group successfully prepared gold nanoparticles-collagen composite hydrogels through supramolecular self-assem...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/704A61K41/00A61K47/32A61P35/00C08F293/00B82Y5/00
CPCA61K9/06A61K9/0024A61K41/0052A61K31/704A61K47/32A61P35/00B82Y5/00C08F293/00A61K2300/00
Inventor 杨文静曹彦鹏汪联辉沈琦张颖
Owner NANJING UNIV OF POSTS & TELECOMM
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