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Novel antineoplastic compound medicine

An anti-tumor drug and anti-tumor technology, applied in the field of medicine

Inactive Publication Date: 2007-09-26
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, the interaction of one or two of ginseng, Ophiopogon japonicus, Schisandra chinensis, cantharidin or its derivatives or its analogues, and toad venom is used to prepare anti-tumor drugs, and there is no report yet.

Method used

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  • Novel antineoplastic compound medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0189] Example 1 Preparation of toad venom extract

[0190] Take toad venom, crush it into fine powder, add 20 times the amount of 80% ethanol to soak, grind, refrigerate overnight, filter the next day, recover the ethanol from the filtrate until it has no alcohol smell, add 10 times the amount of water, mix well, refrigerate, and stand for 24 hours , filtered, and the filtrate was concentrated to a relative density of 1.10 to 1.15, spray-dried, and obtained.

[0191] Three batches of toad venom extract were prepared according to the above process, and the yields are shown in Table 7.

[0192] Identification of toad venom extract

[0193] Take toad venom extract 0.1g, add ethanol 10ml, heat and reflux for 30 minutes, filter, put the filtrate in a 10ml measuring bottle, add ethanol to the mark, and use it as the test solution. Separately take 0.2 g of the reference medicinal material of toad venom, and make a solution of the reference medicinal material in the same way. Then...

Embodiment 2

[0208] Example 2 Preparation of Ginseng Extract

[0209] Preparation of Total Ginsenosides

[0210] Take the ginseng medicinal material, crush it into fine particles, add 10 times the amount of ethanol to reflux and extract twice, each time for 3 hours, combine the extracts, refrigerate, filter, recover the ethanol from the filtrate and concentrate it to a thick paste, add water to an appropriate amount (so that each 1ml is equivalent to 1 g of the original medicinal material), stir well, refrigerate, filter, add the filtrate to the treated macroporous resin column, first use 2 to 3 times the volume of the column to elute, discard the washing solution, and then use 3 Elute with 80% ethanol twice the volume of the column, collect the eluent, recover the ethanol and concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35, and dry it in vacuum to obtain the product.

[0211] Three batches of total ginsenosides were prepared respectively, and the ...

Embodiment 3

[0241] Example 3 Preparation of Ophiopogon japonicus Extract

[0242] Take the Ophiopogon japonicus medicinal material, crush it into fine particles, add 8 times the amount of water to decoct twice, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add ethanol to make the alcohol content reach 80%, refrigerate Stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to a thick paste, add ethanol to make the alcohol content reach 85%, place it in refrigeration for 24 hours, filter, recover ethanol and concentrate to a thick paste, add water to an appropriate amount (make each 1ml is equivalent to 2g of the original medicinal material), stirred well, refrigerated, filtered, and the filtrate was spray-dried to obtain.

[0243] Three batches of Ophiopogon japonicus extracts were prepared respectively, and the yields are shown in Table 10.

[0244] The yield of the Ophiopogon japonicus extract prepared by the process i...

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Abstract

The invention discloses an antineoplastic medicinal composition containing at least ginseng or its extract, ophiopogon root or its extract, schisandra fruit or its extract, the process for preparation and use thereof, wherein the medicament is one or two selected from cantharidin or derivatives or analogues, and toad venoms. The composition can be used for treating hepatic carcinoma, esophagus cancer, cardiac cancer, lung carcinoma, breast cancer, intestinal cancer, malignant lymphoma, hepatitis and cirrhosis.

Description

1. Technical field [0001] The invention relates to a composition comprising ginseng or its extract, Ophiopogon japonicus or its extract, Schisandra chinensis or its extract, and at least one antitumor drug composition, its preparation method and application, and belongs to the field of medical technology . 2. Background technology [0002] Cancer is a kind of disease that seriously threatens human life and health. According to statistics, about 1 million cancer patients are newly discovered in my country every year, while the world kills about 6 million people every year, and puts 10 million people on the verge of death. With the deteriorating environment of human beings, the occurrence of cancer The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human beings in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgical treatment combined with radiotherapy and chemothera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P35/00A61K35/56A61K31/365A61K35/65
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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