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Norcantharidin and production method thereof

The technology of norcantharidin and composition is applied in the field of norcantharidin and its production, which can solve the problems of low cure rate, poor safety and the like, and achieve the effects of low cost, improved utilization rate, and remarkable and reliable curative effect.

Inactive Publication Date: 2014-08-06
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to be effectively used for cancer and overcome the defects of poor drug safety and low cure rate in the prior art

Method used

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  • Norcantharidin and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A pharmaceutical composition of norcantharidin, which is prepared from the following raw materials with a weight ratio:

[0024] 2 parts of Norcantharidin, 200 parts of Oldenlandia diffusa, 200 parts of Triangle, 100 parts of Poria cocos, 100 parts of Saponaria spp, 80 parts of Nepeta, 80 parts of Scutellaria barbata, 50 parts of thistle, 50 parts of Trichosanthes, Acanthopanax senticosus 50 parts and honey honeycomb 20 parts.

[0025] The preparation method is:

[0026] Take Triangle, Poria, Saponaria japonicus, Chinensis, Acanthopanax senticosus, add 70% ethanol for half an hour, reflux extraction twice, 1 hour each time, combine the extracts, filter, and concentrate to a relative density of 1.2g / ml of extract, dried at 80°C, crushed into powder, which is compound A;

[0027] Take Oldenlandia diffusa, Nepeta, Scutellaria barbata, thistle, dew honeycomb, decoct and extract twice with water, add 5 times the weight of water for the first time, decoct and extract for 0.5 hours,...

Embodiment 2

[0044] Zoological experiment

[0045] Acute toxicity experiments with mice showed that: compared with the blank control group, there was no significant difference in mice after administration. The experiment was observed for two consecutive weeks, and the mice's general condition, food intake, drinking water, and weight gain were normal. On the day of administration and within two weeks after administration, no animal deaths were seen, indicating that the drug has low acute toxicity and is safe for clinical use.

Embodiment 3

[0047] Pharmacodynamic experiment:

[0048] 1. Anti-tumor effect experiment

[0049] 1. Experimental materials: drugs: A: the drugs prepared in Example 1 of the present invention; B: control group: Longyuan Huikang-norcantharidin tablets (Shandong Plain Pharmaceutical). Tumor strain: mouse sarcoma S 180 . Animals: Kunming mice, 18-24g.

[0050] 2. Methods and results: Inhibition of transplanted tumors in animals: ① Inhibition of mouse S180: Take the tumor-derived animals that have been inoculated for 7-10 days, extract the ascites tumor fluid under sterile conditions, and inoculate subcutaneously in the right axilla of each mouse 1×10 6 Tumor cells were randomly divided into groups after 24 hours and started to be administered, once a day, with a dosage of 0.2g / kg for 9-11 days. The control group was given sterile saline. The mice were sacrificed the next day after the drug was discontinued, the weight was weighed and the subcutaneous tumor mass was stripped, the tumor weight was...

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Abstract

The invention relates to norcantharidin and a production method thereof. The norcantharidin is prepared from the following raw medicinal materials in parts by weight: 2 parts of norcantharidin, 200 parts of oldenlandia diffusa, 200 parts of rhizoma sparganii, 100 parts of poria, 100 parts of spina gleditsiae, 80 parts of schizonepeta, 80 parts of sculellaria barbata, 50 parts of circium japonicum, 50 parts of trchosahthes kirilowii maxin, 50 parts of manyprickle acanthopanax root and 20 parts of nidus vespae. According to the production method, the peak-valley phenomenon occurring when conventional preparations are administrated frequently can be avoided, and the drug utilization and the compliance of patient administration can be improved, so that the aims of improving curative effects of medicines and reducing adverse response of medicines can be achieved. The norcantharidin has an excellent application prospect.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating tumors and a preparation method thereof, belonging to the field of medicine technology, and in particular to a norcantharidin and a production method thereof. Background technique [0002] Cancer is a type of disease that seriously threatens human life and health. According to statistics, there are about 1 million newly discovered cancer patients in my country each year, and about 6 million lives are claimed every year in the world, and 10 million people are placed on the brink of death. With the deteriorating human living environment, cancer occurs. The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of mankind in the 21st century. The current modern medical treatment of cancer is mainly surgery combined with radiotherapy and chemotherapy. Although surgery can remove the primary lesion, it cannot fundamentally...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/902A61P35/00A61K35/64A61K31/34
Inventor 林凡儒林凡友赵振桥
Owner 仁和堂药业有限公司
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