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Medicinal composition of oxymatrine and polysaccharide

A composition, the technology of matrine, applied in the field of medicine, to achieve the effect of ensuring safety, small quality difference and definite curative effect

Inactive Publication Date: 2007-12-05
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, it has not been reported that matrine, Ganoderma lucidum or Ganoderma lucidum polysaccharide interacts with Lentinan to prepare a medicine for treating cancer or hepatitis.

Method used

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  • Medicinal composition of oxymatrine and polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Example 1 Preparation of Ganoderma lucidum polysaccharide

[0124] Take Ganoderma lucidum medicinal materials, crush them into coarse particles, add 4 times the amount of water to wet overnight, decoct three times the next day, add 12 times the amount of water for 3 hours for the first time, add 10 times the amount of water for 2 hours for the second time, and decoct for 2 hours for the second time. Add 10 times the amount of water three times and cook for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.15, filter, remove the protein from the filtrate by the Sevage method, filter, add ethanol to the filtrate until the alcohol content is 60%, stir well, refrigerate for 24 hours, filter, collect the filter cake, add an appropriate amount of water and stir to dissolve, filter, add ethanol to the filtrate until the alcohol content is 85%, stir well, refrigerate for 24 hours, filter Then, collect the filter cake, add appropri...

Embodiment 2

[0135] Preparation of 2 KLX composition powder for injection

[0136] 1. Prescription:

[0137] Matrine 400g

[0138] Ganoderma lucidum polysaccharide 28.8g (equivalent to 3kg of the original medicinal material)

[0139] Mushroom polysaccharide 8g

[0140] Polysorbate 80 50g

[0141] Mannitol 300g

[0142] Sterile water for injection added to 5000ml

[0143]

[0144] A total of 1000 pieces were prepared

[0145] 2. Specific steps:

[0146] 1) First, aseptically treat the container for liquid dispensing, antibiotic glass bottle, rubber stopper, etc.

[0147] 2) Weigh the raw materials and auxiliary materials according to the prescription amount.

[0148] 3) Add an appropriate amount of water for injection to matrine and mannitol, heat and stir to dissolve, take 70% of sterile water for injection, add polysorbate 80, heat and stir to dissolve, and then add the prescription amount of Ganoderma lucidum polysaccharide and shii...

Embodiment 3

[0156] Example 3 Preparation of KLX composition water injection

[0157] 1. Prescription:

[0158] Matrine 400g

[0159] Ganoderma lucidum polysaccharide 28.8g (equivalent to 3kg of the original medicinal material)

[0160] Mushroom polysaccharide 8g

[0161] Polysorbate 80 50g

[0162] Add water for injection to 5000ml

[0163]

[0164] A total of 1000 pieces were prepared

[0165] 2. Specific steps:

[0166] 1) Dispose of the pipelines and containers for liquid dispensing one day in advance, and rinse with fresh water for injection before use.

[0167] 2) Add an appropriate amount of water for injection to matrine, heat and stir to dissolve, take 70% sterile water for injection, add polysorbate 80, heat and stir to dissolve, then add the prescription amount of Ganoderma lucidum polysaccharide and lentinan, and stir Completely dissolved. Combine the above solutions and add sterile water for injection to 5000ml.

[0168] 3) Add 0....

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Abstract

The present invention belongs to the field of medicine technology, and discloses one kind of mechanical composition, which consists of kurarione, glossy ganoderma or glossy ganoderma polysaccharide, and lentinan. It is used in treating liver cancer, lung cancer, osophagus cancer, hepatitis, etc and may be also used in the operational treatment, radiotherapy and chemotherapy of cancer. It has synergistic effect of the components, may be prepared into different forms and possesses wide application foreground.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of matrine, Ganoderma lucidum or Ganoderma lucidum polysaccharide and lentinan, a preparation method and application thereof, and belongs to the technical field of medicine. 2. Background technology [0002] Cancer is a kind of disease that seriously threatens human life and health. According to statistics, about 1 million new cancer patients are discovered in my country every year, while the world kills about 6 million people every year and puts 10 million people on the brink of death. With the deterioration of the human living environment, the occurrence of cancer The rate is increasing year by year. The World Health Organization predicts that cancer will become the "number one killer" of mankind in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgery combined with radiotherapy and chemotherapy. Although surgery can remove the primary lesion, i...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K31/715A61K31/4375A61K9/08A61K9/00A61P35/00A61P1/16
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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