External nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof

Abstract

The invention discloses external nano-hydroxyapatite / polydopamine wet adhesion type styptic powder and a preparation method thereof. The styptic powder is nano-hydroxyapatite loaded with polydopamine.The preparation method comprises the following steps: adding nano-hydroxyapatite and dopamine into a weakly alkaline solution, and reacting at room temperature; and carrying out freeze drying on theproduct to obtain the nano-hydroxyapatite / polydopamine needle-like composite styptic powder. The material has a multifunctional hydroxyapatite and polydopamine structure, and can be further modified with many substrates. The material can be applied to hemostasis in different forms in different dosage forms, can be prepared into emergency lifesaving powder, hemostasis hydrogel, self-adhesive dressing, hemostasis antibacterial sponge and the like by being integrated with other medical materials and medical instruments, and the novel drug delivery carrier can be prepared by doping or crosslinkingantibacterial, wound healing promoting and pain relieving drugs and nano-hydroxyapatite or reacting the drugs with polydopamine, and multifunctional integration of the hemostatic material is realized.

Description

Technical field [0001] The invention specifically relates to a nano-hydroxyapatite / polydopamine wet adhesion type hemostatic powder for external use and a preparation method thereof, belonging to the field of biomedical hemostatic materials. Background technique [0002] Uncontrollable bleeding is considered to be the primary cause of death in operations, wars, traffic accidents, etc. The research on hemostatic materials at home and abroad is mostly limited to mild bleeding, and the research on hemostasis of uncontrollable bleeding is still a research blank. At present, the most common solution for uncontrollable bleeding is still to take gauze bandage to compress the bleeding site to achieve hemostasis. Although it can have a certain hemostasis effect, the compression hemostasis method often leads to secondary bleeding after the compression is relieved. Hemostatic materials that can not only adhere to the wound to prevent bleeding, but also form a stable blood clot at the wound ...

AI Technical Summary

Problems solved by technology

[0005] Hydroxyapatite is the main component of human bones and teeth. It has good biocompatibility, non-toxicity, non-irritation, no human rejection, no aging, sensitization and carcinogenicity, and can chemically combine with bone tissue. It is widely used as bone substitute materials, plastic and cosmetic surgery materials, dental materials, chromatography purification materials, calcium supplements, etc., but there are no related reports on hemostatic materials.

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