External nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof

A nano-hydroxyapatite and polydopamine technology, applied in the field of biomedical hemostatic materials, achieves the effects of high repeatability, small batch-to-batch variation, and superior biocompatibility

Inactive Publication Date: 2020-07-28
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Hydroxyapatite is the main component of human bones and teeth. It has good biocompatibility, non-toxicity, non-irritation, no human rejection, no aging, sensitization and carcinogenicity, and can chemically combine with bone tis

Method used

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  • External nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof
  • External nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof
  • External nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] Add 0.50g nano-hydroxyapatite and 0.01g dopamine to 100mL pH=7.5 disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution or disodium hydrogen phosphate-dipotassium hydrogen phosphate buffer solution, add 0.50g nano-hydroxyapatite and 0.01g dopamine, ultrasonic for 15min, react at room temperature for 12h ; The product is freeze-dried for 6 hours to prepare the HAP / PDA nano mesh composite material. by figure 1 (a) (50:1) HAP / PDA transmission electron microscope image and figure 1 (b) (50:1) The XRD pattern of HAP / PDA shows that the HAP / PDA nano-needle composite material is prepared.

Example Embodiment

[0030] Example 2

[0031] Add 1.00g nano-hydroxyapatite and 0.05g dopamine to 100mL pH=8.5 tris(hydroxymethyl)aminomethane-hydrochloric acid buffer solution or boric acid-borax buffer solution, ultrasonic for 15min, reaction at room temperature for 24h; product freeze-drying for 12h , Made SiO 2 / PDA nano needle composite material. by figure 1 (a) (20:1) HAP / PDA transmission electron microscope image and figure 1 (b) (20:1) The XRD pattern of HAP / PDA shows that the HAP / PDA nano-needle composite material is prepared.

Example Embodiment

[0032] Example 3

[0033] In 100mL pH=9.5 sodium carbonate-sodium bicarbonate buffer solution or sodium barbiturate-hydrochloric acid buffer solution, add 2.00g nano-hydroxyapatite and 0.20g dopamine, ultrasonic for 15min, reaction at room temperature for 36h; product freeze-drying for 24h, Prepared HAP / PDA nano-needle composite material. by figure 1 (a) (10:1) HAP / PDA transmission electron microscope image and figure 1 (b) (10:1) XRD pattern of HAP / PDA shows that the HAP / PDA nano-needle composite material is prepared.

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Abstract

The invention discloses external nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and a preparation method thereof. The styptic powder is nano-hydroxyapatite loaded with polydopamine.The preparation method comprises the following steps: adding nano-hydroxyapatite and dopamine into a weakly alkaline solution, and reacting at room temperature; and carrying out freeze drying on theproduct to obtain the nano-hydroxyapatite/polydopamine needle-like composite styptic powder. The material has a multifunctional hydroxyapatite and polydopamine structure, and can be further modified with many substrates. The material can be applied to hemostasis in different forms in different dosage forms, can be prepared into emergency lifesaving powder, hemostasis hydrogel, self-adhesive dressing, hemostasis antibacterial sponge and the like by being integrated with other medical materials and medical instruments, and the novel drug delivery carrier can be prepared by doping or crosslinkingantibacterial, wound healing promoting and pain relieving drugs and nano-hydroxyapatite or reacting the drugs with polydopamine, and multifunctional integration of the hemostatic material is realized.

Description

Technical field [0001] The invention specifically relates to a nano-hydroxyapatite / polydopamine wet adhesion type hemostatic powder for external use and a preparation method thereof, belonging to the field of biomedical hemostatic materials. Background technique [0002] Uncontrollable bleeding is considered to be the primary cause of death in operations, wars, traffic accidents, etc. The research on hemostatic materials at home and abroad is mostly limited to mild bleeding, and the research on hemostasis of uncontrollable bleeding is still a research blank. At present, the most common solution for uncontrollable bleeding is still to take gauze bandage to compress the bleeding site to achieve hemostasis. Although it can have a certain hemostasis effect, the compression hemostasis method often leads to secondary bleeding after the compression is relieved. Hemostatic materials that can not only adhere to the wound to prevent bleeding, but also form a stable blood clot at the wound ...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02A61L24/04
CPCA61L24/001A61L24/0015A61L24/02A61L24/046A61L2300/402A61L2300/404A61L2300/412A61L2400/04A61L2400/12C08L79/04
Inventor 乔卫红龚孟翔柳春玉刘宸宇
Owner DALIAN UNIV OF TECH
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