Production method of bone tissue engineering scaffold material artificial tooth root capable of improving synostosis

Abstract

The invention provides a production method of a bone tissue engineering scaffold material artificial tooth root. The method includes the six steps of: preparing a steel model, preparing an initial green body of the artificial tooth root, processing pores, filling the pores with a PLLA / nHA composite, spray-coating the green body with a PGA / nHA composite coating, and performing surface degradation.In the invention, the initial green body of the artificial tooth root is prepared with a PEEK and HA crystal whisker composite material as a bone tissue engineering scaffold material, wherein at corresponding positions on the green body, pores are processed and are filled with the degradable PLLA / nHA active composite material; finally, the green body is spray-coated with the PGA / nHA bioactive coating and then surface degradation is carried out to produce the bone tissue engineering scaffold material artificial tooth root capable of improving synostosis function. The artificial tooth root can be combined with bone through self-repairing on bones with bone induction cells, so that the elasticity modulus of the tooth root is matched with alveolar bone better, and bone absorption of the alveolar bone is not liable to be caused. The artificial tooth root is greatly better than a common artificial tooth root.

Description

technical field [0001] The invention relates to a preparation method of an artificial tooth root, in particular to a preparation method of an artificial tooth root of a bone tissue engineering scaffold material capable of enhancing osseointegration, and belongs to the technical field of preparation technology of dental medical materials. Background technique [0002] Bone tissue engineering is a science that uses the principles of cell biology and engineering to research and develop biological substitutes for repairing and improving the shape and function of damaged bone tissue. Tooth root also belongs to a kind of tough bone tissue, and tooth extraction will greatly damage the bone tissue. How to replace the shape and function of the tooth root with bio-substitute materials, and make it more stable with the alveolar bone, is the key research direction of bone tissue engineering scaffold materials for artificial tooth roots. Now all over the world, metal titanium with better...

AI Technical Summary

Problems solved by technology

Referring to foreign materials, it can be found that: ①Wang et al. studied nano-TiO 2 Oral administration to mice can trigger an inflammatory response in the heart, and nanoparticles accumulate in the liver, leading to hepatic lobular necrosis; ②SaKai found that nano-TiO 2 It will cause DNA damage and cell apoptosis; ③ Hoyt research believes that once nano-TiO 2 Particles are inhaled by humans or other organisms through breathing. When the Brownian motion in the body exceeds a certain amount, it may destroy the human defense system

In addition, bone resorption around the titanium-based artificial tooth root is a complicated problem. In addition to the toxic effects of titanium, the elastic modulus of titanium metal is too high at 105Gpa, while the elastic modulus of bone is only 19-21Gpa. The difference between the two is too large, and it is easy to cause occlusion Phenomenon, causing bone resorption, and oral hygiene problems, etc., are also one of the causes of bone resorption

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