High-expansion degradable nasal cavity filling hemostasis material and preparation method thereof

A hemostatic material and nasal cavity technology, applied in the field of medical biomaterials, can solve the problems that the product cannot be put into the nasal cavity as a whole, cannot fully exert the hemostatic effect of filling, poor biocompatibility, etc., achieves superior physical and chemical properties, and avoids secondary damage to the mucosa Sexual bleeding, strong plasticity

Inactive Publication Date: 2017-02-22
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, a calcium alginate sponge medical dressing disclosed in invention patent 102258801A has the characteristics of good biocompatibility, compliance and liquid absorption, and gelation occurs when it contacts with blood or wound secretion sodium salt, which can play a better role. However, because it is too soft, it liquefies rapidly after sodium-calcium exchange, so that the compression force is not enough to fully exert the hemostatic effect of filling; the invention patent CN100341933C discloses a water-swellable carboxymethyl chitosan sponge, which uses calcium ions Cross-linking, environmentally friendly process an

Method used

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  • High-expansion degradable nasal cavity filling hemostasis material and preparation method thereof
  • High-expansion degradable nasal cavity filling hemostasis material and preparation method thereof
  • High-expansion degradable nasal cavity filling hemostasis material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0042] Embodiment 1,

[0043] (1) 0.5 g of medical carboxymethyl chitosan with a degree of substitution of 80% and a viscosity-average molecular weight of 150,000 is placed in 100 g of 50° C. purified water and stirred and dissolved to obtain an aqueous solution of carboxymethyl chitosan, and then a 4-g length Bacterial cellulose with a thickness of 100 μm was added to the above solution for homogenization to obtain a microfiber-suspended carboxymethyl chitosan solution.

[0044] (2) Add 0.1g activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide to the amino group and carboxyl group of carboxymethyl chitosan in the suspension to carry out activation treatment, will The feed liquid was poured into the corresponding mold, and left for 1 hour, carboxymethyl chitosan self-crosslinked to form a hydrogel, washed with purified water to remove the activator EDC, and vacuum freeze-dried for 24 hours to obtain an intermediate product, a loose porous sponge.

[0045](3) 100 g of a so...

Example Embodiment

[0046] Embodiment 2,

[0047] (1) 10 g of medical carboxymethyl chitosan with a degree of substitution of 85% and a molecular weight of 200,000 is placed in 100 g of 50° C. purified water and stirred and dissolved to obtain an aqueous solution of carboxymethyl chitosan, and then 0.1 g of the carboxymethyl chitosan with a length of 150 μm Bacterial cellulose was added to the above solution for homogenization treatment to obtain microfiber suspension carboxymethyl chitosan solution.

[0048] (2) Add 5g activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide to the amino group and carboxyl group of carboxymethyl chitosan in the suspension to carry out activation treatment, the material The solution was poured into corresponding molds and left for 8 hours. Carboxymethyl chitosan self-crosslinked to form a hydrogel, washed with purified water to remove the activator EDC, and vacuum freeze-dried for 48 hours to obtain an intermediate product, a loose porous sponge.

[0049] (3) Pr...

Example Embodiment

[0050] Embodiment 3,

[0051] (1) 4g of medical carboxymethyl chitosan with a degree of substitution of 90% and a molecular weight of 300,000 is placed in 100g of 50°C purified water and stirred and dissolved to obtain an aqueous solution of carboxymethyl chitosan, and then 2g of bacteria with a length of 350 μm The cellulose is added into the above solution for homogenization treatment to obtain a microfiber suspension carboxymethyl chitosan solution.

[0052] (2) Add 2g activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide to the amino group and carboxyl group of carboxymethyl chitosan in the suspension to carry out activation treatment, the material The solution was poured into corresponding molds and left for 8 hours. Carboxymethyl chitosan self-crosslinked to form a hydrogel, washed with purified water to remove the activator EDC, and vacuum freeze-dried for 36 hours to obtain a loose porous sponge as an intermediate product.

[0053] (3) 100 g of a solution of the de...

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Abstract

The invention discloses a high-expansion degradable nasal cavity filling hemostasis material and a preparation method thereof. The hemostasis material is a product prepared by taking carboxymethyl chitosan, bacterial cellulose, water, an activating agent and a degradation regulating agent as raw materials. According to the hemostasis material, the implantation size is small, the hemostasis material not only can be integrally implanted into the nasal cavity, but also can be implanted after being trimmed as needed, and clinic use is flexible and convenient; the liquid absorbing speed is high, the hemostasis material can absorb liquid to be completely expanded within 20 seconds, and the expanding size reaches 10 times that of the self size; the material is low in weight, flexible, rich in elasticity, high in plasticity, full and uniform in oppression to the mucosa, good in patient comfort, great in market application and popularization potential and wide in social benefit prospect.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a high-expansion degradable nasal cavity filling hemostatic material and a preparation method thereof. Background technique [0002] A large number of people around the world are troubled by nasal diseases such as sinusitis, nasal polyps, and nasal cavity tumors. Especially in my country, with the rapid economic development in recent years, environmental problems have become increasingly serious, and air pollution has spread widely. The resulting external stimuli have increased the number of patients with nasal cavity diseases year by year. At present, the effective means to solve such diseases clinically is intranasal Endoscopic surgery, and postoperative patients need nasal packing to stop bleeding. Therefore, the convenience of using hemostatic materials and the pain relief or rebleeding reduction caused by the extraction process to patients have always been the focus of clin...

Claims

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Application Information

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IPC IPC(8): A61L24/08
CPCA61L24/08A61L2400/04C08L5/08C08L1/02
Inventor 郭刚赵庆凯张素花徐秀周颖孙先昌王彬
Owner YANTAI ZHENGHAI BIO TECH
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