High-expansion degradable nasal cavity filling hemostasis material and preparation method thereof

Abstract

The invention discloses a high-expansion degradable nasal cavity filling hemostasis material and a preparation method thereof. The hemostasis material is a product prepared by taking carboxymethyl chitosan, bacterial cellulose, water, an activating agent and a degradation regulating agent as raw materials. According to the hemostasis material, the implantation size is small, the hemostasis material not only can be integrally implanted into the nasal cavity, but also can be implanted after being trimmed as needed, and clinic use is flexible and convenient; the liquid absorbing speed is high, the hemostasis material can absorb liquid to be completely expanded within 20 seconds, and the expanding size reaches 10 times that of the self size; the material is low in weight, flexible, rich in elasticity, high in plasticity, full and uniform in oppression to the mucosa, good in patient comfort, great in market application and popularization potential and wide in social benefit prospect.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a high-expansion degradable nasal cavity filling hemostatic material and a preparation method thereof. Background technique [0002] A large number of people around the world are troubled by nasal diseases such as sinusitis, nasal polyps, and nasal cavity tumors. Especially in my country, with the rapid economic development in recent years, environmental problems have become increasingly serious, and air pollution has spread widely. The resulting external stimuli have increased the number of patients with nasal cavity diseases year by year. At present, the effective means to solve such diseases clinically is intranasal Endoscopic surgery, and postoperative patients need nasal packing to stop bleeding. Therefore, the convenience of using hemostatic materials and the pain relief or rebleeding reduction caused by the extraction process to patients have always been the focus of clin...

AI Technical Summary

Problems solved by technology

Among them, a calcium alginate sponge medical dressing disclosed in invention patent 102258801A has the characteristics of good biocompatibility, compliance and liquid absorption, and gelation occurs when it contacts with blood or wound secretion sodium salt, which can play a better role. However, because it is too soft, it liquefies rapidly after sodium-calcium exchange, so that the compression force is not enough to fully exert the hemostatic effect of filling; the invention patent CN100341933C discloses a water-swellable carboxymethyl chitosan sponge, which uses calcium ions Cross-linking, environmentally friendly process and no residue, but the product still has major performance defects such as brittleness and fragility, which greatly limits its use; a hemostatic sponge disclosed in the invention patent NL2002931 (C) uses polyether ester and polyurethane The polymeric sponge synthesized by synthetic polymer has rich elastic support and ideal self-degradation performance in vivo, but the biocompatibility is poor and the product cannot be put into the nasal cavity as a whole; while the traditional collagen hemostatic sponge is mostly cross-linked by aldehyde chemical reagents , chemical residues in the process will inevitably cause tissue toxicity

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