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Curcumin Pickering emulsion with colon targeted transmission function, preparation method and application thereof

A colon-targeting, curcumin technology, applied in non-active ingredients medical preparations, applications, food ingredients functions, etc., can solve problems such as limiting the application of Pickering emulsions, achieve excellent load properties, enhance stability, and improve safety. sexual effect

Active Publication Date: 2020-04-14
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the solid particles used to stabilize Pickering emulsions mainly include silicon dioxide and synthetic latex. Due to the safety problems of these particles, the application of Pickering emulsions in the food industry is limited.

Method used

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  • Curcumin Pickering emulsion with colon targeted transmission function, preparation method and application thereof
  • Curcumin Pickering emulsion with colon targeted transmission function, preparation method and application thereof
  • Curcumin Pickering emulsion with colon targeted transmission function, preparation method and application thereof

Examples

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preparation example Construction

[0036] The preparation method of required material and solution among the present invention is as follows:

[0037] Preparation of carboxymethyl konjac glucomannan (CMKGM): Weigh 5g of konjac glucomannan and dissolve it in 40mL of 70% (v / v) ethanol, add 40% (w / v) NaOH solution, dissolve in Stir in a water bath at 50°C for 1 h for alkalization. After alkalization and swelling, according to the chloroacetic acid:NaOH molar ratio of 1:1~3:1, add the aqueous solution of chloroacetic acid, react at 50°C for 2 hours, adjust the pH of the solution to 7 with 1.0mol / L HCl, collect the precipitate, and use Washed several times with 70% (v / v) ethanol, 95% (v / v) ethanol and absolute ethanol, dried with hot air at 50°C to constant weight, obtained a degree of substitution of 0.28~0.74 and a potential of -26.9mV~- CMKGM of 38.6mV.

[0038]1% (w / v) ovalbumin stock solution: Accurately weigh 1g of ovalbumin and dissolve it in 100mL deionized water, stir at constant temperature for 30min und...

Embodiment 1

[0052] The preparation method of curcumin Pickering emulsion delivery system in the present embodiment may further comprise the steps:

[0053] 1. Mix 0.2% (w / v) ovalbumin aqueous solution and 0.2% (w / v) carboxymethyl konjac glucomannan aqueous solution with a degree of substitution of 0.28 and a potential of -26.9mV according to the volume of 5:1 Mix them together, adjust the pH value of the solution to 2.5, and react at 25°C to prepare ovalbumin-carboxymethyl konjac glucomannan complex soft gel.

[0054] 2. Disperse the soft gel obtained in step 1 for 20 minutes at a rotational speed of 10000 r / min to obtain ovalbumin-carboxymethyl konjac glucomannan microgel.

[0055] 3. Add 0.22% (w / v) dihydromyricetin as a crosslinking agent to the microgel obtained in step 2, adjust the pH value to 3, and stir at a speed of 4000r / min for 6h to prepare soft solid particles.

[0056] 4. Mix the soft solid particles obtained in step 3 with 10 mg / mL curcumin oil phase at a volume ratio of 4...

Embodiment 2

[0061] The preparation method of curcumin Pickering emulsion delivery system in the present embodiment may further comprise the steps:

[0062] 1. Mix 0.4% (w / v) ovalbumin aqueous solution and 0.4% (w / v) carboxymethyl konjac glucomannan aqueous solution with a degree of substitution of 0.44 and a potential of -32.3mV according to the volume of 4:1 Mix them together, adjust the pH value of the solution to 4, and react at 30°C to prepare ovalbumin-carboxymethyl konjac glucomannan complex soft gel.

[0063] 2. Disperse the soft gel obtained in step 1 for 25 minutes at a rotational speed of 11,000 r / min to obtain ovalbumin-carboxymethyl konjac glucomannan microgel.

[0064] 3. Add 0.1% dihydromyricetin as a cross-linking agent to the microgel obtained in step 2, adjust the pH value to 3.5, and stir at a speed of 3500 r / min for 7 hours to prepare soft solid particles.

[0065] 4. Mix the soft solid particles obtained in step 3 with 11mg / mL curcumin oil phase at a volume ratio of 6...

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Abstract

The invention provides a curcumin Pickering emulsion with colon targeted transmission function, a preparation method and application thereof. The method includes: firstly mixing ovalbumin with carboxymethyl konjac glucomannan to form polyelectrolyte compound soft gel, then conducting high-speed homogeneous dispersion to form microgel, then taking soft solid particles formed by crosslinking of dihydromyricetin as an emulsifier, and taking a medium-chain triglyceride solution of curcumin as the oil phase to prepare the curcumin Pickering emulsion. According to the invention, the curcumin Pickering emulsion with colon targeted transmission function can be prepared by changing the soft gel, the microgel and the dihydromyricetin crosslinking conditions. The curcumin Pickering emulsion preparedby the preparation method disclosed by the invention not only reserves the colon targeted transmission properties of carboxymethyl konjac glucomannan, but also can avoid the adverse effects of the environment on curcumin, and the bioavailability of curcumin is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of targeted release, and in particular relates to curcumin Pickering emulsion with colon targeted delivery function, its preparation method and application. Background technique [0002] Curcumin is the active ingredient of the perennial herb turmeric, which has pharmacological effects such as anti-oxidation, anti-inflammation, anti-cancer, anti-tumor, anti-allergy, enhancing fiber activity and anti-Alzheimer's disease. Various cell signal transduction pathways, such as inhibiting colon cancer cell cycle progression, reducing angiogenesis and inducing apoptosis. Due to the strong intermolecular and intramolecular hydrogen bonds, the solubility and dissolution rate of curcumin in water are extremely low, which makes the compatibility of curcumin with other food raw materials during food processing extremely poor, and the bioavailability in the body is extremely low , and curcumin is also very sensitive to en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/42A61K47/36A61K47/14A61K31/12A61P29/00A23L33/105A23L29/00A23L29/30A23L29/10
CPCA23V2002/00A61K9/10A61K31/12A61K47/14A61K47/36A61K47/42A23L29/045A23L29/10A23L29/30A23L33/105A61P29/00A23V2200/222A23V2200/30A23V2250/2112A23V2250/5428
Inventor 黄国清肖军霞曹亚倩李康昱
Owner QINGDAO AGRI UNIV
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