19 results about "Total blood" patented technology

The invention relates to a method for determining a total fluid volume flow (1) in the region of an implanted vascular support system (2), comprising the following steps: a) determining a reference temperature (3) of the fluid, b) determining a motor temperature (4) of an electric motor (5) of the support system (2), c) determining the thermal dissipation loss (6) of the electric motor (5), d) ascertaining the total fluid volume flow (1) using the reference temperature (3), the motor temperature (4), and the thermal dissipation loss (6) of the electric motor (5).

The invention provides a real-time drift correction electronic sensing system based on a smart phone and a detection method. The real-time drift correction electronic sensing system comprises a sensing integrated chip, an electronic signal acquisition circuit and terminal equipment, the sensing integrated chip is in communication connection with the terminal equipment through the electronic signal acquisition circuit; the sensing integrated chip is an AuNPs / MXene modified working electrode and is used for sensing and detecting a target myocardial marker in whole blood; the electronic signal acquisition circuit is used for connecting the sensing integrated chip and terminal equipment to realize signal acquisition and transmission; and the terminal equipment receives, processes and displays the sensing signal, and gives an alarm when the detected concentration exceeds a normal range. According to the invention, a double-signal real-time drift correction mechanism is adopted, so that the stability is improved. And full-process detection and intelligent early warning can be completed within 5 minutes. The integrated design realizes rapid home detection, does not need professional operation, and provides an efficient and portable scheme for early diagnosis of myocardial infarction.

The utility model discloses a blood pad blood volume counting and counting device, a lifting belt of each blood pad is provided with an electronic tag, the blood pad blood volume counting and counting device comprises an electronic scale and a carrying disc, the electronic scale comprises a shell, a weighing table and a display table, and the weighing table is arranged on the top surface of the shell and located on the rear side of the shell; the display table is arranged on the top surface of the shell and is positioned on the front side of the shell; the carrying disc is suitable for being placed on the weighing table and is used for storing a used blood pad; the electronic scale further comprises a supporting table used for supporting the lifting belt of the blood pad, and the supporting table is provided with a tag reader used for reading the electronic tag. The display table is configured to be capable of displaying the total blood content of the blood pads and the number of the blood pads. According to the counting and counting device for the blood volume of the blood pad, the dual functions of counting the blood pad and measuring the blood volume can be automatically completed, and the efficiency and the accuracy of measuring the blood volume in the operation process are improved.

A method for determining minimum or maximum total blood volume of a donor for a blood processing procedure, using a blood processing device including a controller. The method includes inputting at least one donor characteristic for a donor, performing at least two separate total blood volume calculations to produce at least a first total blood volume and a second total blood volume, and selecting the lowest total blood volume as the minimum total blood volume of the donor or selecting the highest total blood volume for the maximum total blood volume of a donor.

A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and / or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

A method for collecting blood components using a medical system, the method comprising: receiving data associated with a subject by the medical system, the data associated with the subject including the subject's initial hematocrit value; determining the amount of subject-specific pure component to be collected by the medical system, the amount of subject-specific pure component to be collected by the medical system being determined using the subject's hematocrit value, the subject's total blood volume, and a target change in the hematocrit value; and performing a component collection process using the medical system to collect the determined amount of subject-specific pure component.

The invention discloses a pulsating flow blood injury assessment system and method for a double-loop nested low-pre-charge medical instrument, and belongs to the technical field of medical instruments. The system comprises a physiological pulsating pressure simulation loop and an instrument test blood carrying loop. The physiological pulsating pressure simulation loop is composed of a mechanical human body circulation simulation system and comprises a left ventricle, an aorta compliance cavity, a pipeline, a sensor and a power system. The instrument test blood carrying loop comprises a flexible blood bag, a blood carrying pipeline and a to-be-tested medical instrument. The two loops are nested and coupled through the flexible blood bag, and the flexible blood bag is immersed in water-glycerol liquid of the physiological pulsating pressure simulation loop to realize non-contact pressure transmission. The total blood pre-filling amount of the system is smaller than 500 mL, an SEBS blood bag and a heparinization coating are adopted, a non-contact sensor and an actuator are combined, and extra blood damage is remarkably reduced. According to the invention, low-pre-charge and high-biocompatibility pulsating flow blood injury accurate evaluation is realized, and the method is suitable for blood compatibility test of medical instruments such as a ventricular assist device and the like.

A method for acquiring a blood component using a medical system includes: receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including an initial hematocrit of the subject; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system being determined using a hematocrit of the subject, a total blood volume of the subject, and a target change in hematocrit; and performing, using the medical system, a component donation process to acquire the identified subject-specific pure component to be acquired.

This disclosure provides Single cell Isotopomer Distributions and Energetics of Translation under Energetic Stress (SIDETES), a novel strategy to deconvolve metabolic heterogeneity in complex cellular environments, such as tumor and other tumor-resident cell populations, endocrine tissues, whole blood (Peripheral Blood Mononuclear Cells (PBMCs), or lymphoid organs. SIDETES can examine energetic dependence of a substrate, an inhibitor / activator, or a genetic change on rare cells in tumors, and obtain the network response for cells sorted by energy.

Methods and apparatus for multi-wavelength (MW) photoplethysmography (PPG)-based trend monitoring are used to monitor changes in total hemoglobin, fluid accumulation in circulation (plasma volume) and tissues (interstitial fluid volume), total blood volume, and tissue perfusion (microcirculation). The methods and systems provide integration of automated decision support in both medical-grade and non-medical grade wearables for continuous body fluid management guided by MW PPG measurements. Recommendations for optimizing physiological function, including management of fluid intake, restriction or removal, co-administration of cardiovascular medication, and red blood cell transfusion may be provided. Blood loss detection and transfusion-related recommendations may be made based in assessing whole-body hemoglobin mass changes by differentiating dilution-related variations in hemoglobin concentration from net changes in hemoglobin mass due to red blood cell loss or transfusion. Plasma dilution-related fluctuations in plasma volume and corresponding blood volume changes may also be monitored alongside fluctuations in tissue fluid volume and transcapillary fluid shifts. The system may provide clinically relevant trend data for clinician interpretation and real-time alerts for assessing fluid status, including intravascular and extravascular fluid accumulation, total blood volume changes, plasma volume, and net hemoglobin mass variations. Clinical guidance on fluid management, real-time alerts for imminent edema or dehydration risks, and notifications regarding potential blood loss or transfusion effects on hemoglobin levels may be provided. In a non-clinical setting, the system advises on fluid intake or restriction based on fluid accumulation trends in circulation and tissues which are an indication of plasma and tissue hydration status, and prompts users to seek medical attention when a significant reduction in hemoglobin is detected.

Methods and apparatus for multi -wavelength (MW) photoplethysmography (PPG)-based trend monitoring are used to monitor changes in total hemoglobin, fluid accumulation in circulation (plasma volume) and tissues (interstitial fluid volume), total blood volume, and tissue perfusion (microcirculation). The methods and systems provide integration of automated decision support in both medical-grade and non-medical grade wearables for continuous body fluid management guided by MW PPG measurements. Recommendations for optimizing physiological function, including management of fluid intake, restriction or removal, co-administration of cardiovascular medication, and red blood cell transfusion may be provided. Blood loss detection and transfusion- related recommendations may be made based in assessing whole-body hemoglobin mass changes by differentiating dilution-related variations in hemoglobin concentration from net changes in hemoglobin mass due to red blood cell loss or transfusion. Plasma dilution-related fluctuations in plasma volume and corresponding blood volume changes may also be monitored alongside fluctuations in tissue fluid volume and transcapillary fluid shifts. The system may provide clinically relevant trend data for clinician interpretation and real-time alerts for assessing fluid status, including intravascular and extravascular fluid accumulation, total blood volume changes, plasma volume, and net hemoglobin mass variations. Clinical guidance on fluid management, real-time alerts for imminent edema or dehydration risks, and notifications regarding potential blood loss or transfusion effects on hemoglobin levels may be provided. In a non-clinical setting, the system advises on fluid intake or restriction based on fluid accumulation trends in circulation and tissues which are an indication of plasma and tissue hydration status, and prompts users to seek medical attention when a significant reduction in hemoglobin is detected.

Apparatuses and methods for measuring total blood volume with ultrasound are disclosed. In one embodiment, a system for monitoring a blood volume of a patient includes an ultrasound transmitter configured for emitting an ultrasound toward a target blood vessel of the patient; and an ultrasound receiver configured for receiving the ultrasound reflected from the target blood vessel of the patient. The system also includes, a controller configured for: determining an expanded state of the blood vessel based on the ultrasound reflected from the target blood vessel; determining a collapsed stated of the blood vessel based on the ultrasound reflected from the target blood vessel; and determining the blood volume of the patient based on the ratio of the collapsed stated and the expanded stated of the blood vessel.

The invention discloses dynamic noninvasive blood glucose monitoring equipment based on fusion of multi-wavelength PPG and body temperature sensing, and relates to the technical field of noninvasive blood glucose monitoring, the equipment comprises an equipment shell, and a multi-wavelength PPG signal acquisition module, a body temperature sensing module, a signal processing module and a power management module which are arranged on the equipment shell, the multi-wavelength PPG signal acquisition module adopts at least three light sources with specific wavelengths which respectively correspond to characteristic absorption wavebands of an epidermal layer, a dermal papilla layer and a dermal reticular layer, and the layered blood volume contribution factor calculation unit quantifies contribution degrees of capillary networks of different skin layers to the total blood volume; a dynamic adaptive weight distribution unit dynamically distributes fusion weights for PPG signals of all wavelengths; the blood glucose calculation unit calculates the blood glucose concentration based on the fusion signal through a multi-branch CNN-BiLSTM mixed neural network, the equipment can overcome physiological interference such as body temperature fluctuation and movement, the precision and continuity of noninvasive blood glucose monitoring are improved, and the equipment is suitable for dynamic blood glucose monitoring of diabetic patients.

The invention provides an image processing method to assess quantitative myocardial blood flow and / or myocardial flow reserve, comprising the steps of: (a) pre-processing of images comprises: (i) reconstructing dynamic cine 3D tomographic myocardial perfusion imaging (MPI) data, (ii) optionally, denoising to improve the quality of image, (iii) extracting blood input function from a region of interest (ROI) of the left ventricle blood cavity, (iv) estimating the distribution volume (DV), given by the ratio of uptake and washout rates (K1 / k2) to stabilize and improve estimation of K1, k2 and total blood volume (TBV) and subsequent myocardial blood flow measures, and (v) data normalization by dividing by the maximum of the blood input function; (b) assessing the individual signals pre-processed in step (a) to generate K1 and TBV parametric maps using artificial neural network; (c) post-processing of K1, k2 and TBV parametric maps; and of rest and stress myocardial blood flow to estimate myocardial flow reserve (MFR) and / or coronary flow reserve (CFR).

The method comprises the following steps: collecting a traditional Chinese medicine containing isoquinoline alkaloid, and finishing the property and flavor tropism and the cold-heat property of the traditional Chinese medicine; preparing liquid medicine with gradient concentration; the method comprises the following steps of: incubating a quail embryo egg, opening a hole to remove an upper shell membrane, dropwise adding PBS (Phosphate Buffer Solution) on the allantoic membrane of the survival quail embryo egg, observing the distribution condition of blood vessels, respectively injecting liquid medicine into the allantoic membrane of the quail embryo egg at a position without blood vessel development, sealing the hole, incubating, and taking all blood vessels connected with the quail embryo and the allantoic membrane of the quail embryo egg as blood vessel samples; the influence difference of the traditional Chinese medicine containing the isoquinoline alkaloids on the angiogenesis area, the total blood vessel number and the capillary vessel number of the quail embryo egg allantoic membrane is tested and evaluated through LSD-t; the method has the advantages that the method is fast, convenient and low in cost, and objective and accurate basis is provided for evaluating the cold-heat property of the traditional Chinese medicine.

The application discloses a blood volume determination method and device based on blood volume, a medium and a product, and relates to the technical field of voluntary blood donation. The method comprises the following steps: acquiring basic information of a blood donor, wherein the basic information of the blood donor comprises gender, weight and height; determining a body mass index of the blood donor based on the basic information of the blood donor; determining total blood volume of the blood donor based on the basic information and the body mass index of the blood donor; and determining a recommended blood donation volume of the blood donor based on the total blood volume of the blood donor. The application can improve blood donation safety and blood collection quality.

The disclosed total blood volume determination systems and methods provide for a faster, simpler, more practical, less invasive, and more flexibly deployable device for blood volume measurement. These systems and methods are based on measuring, in a patient's bloodstream, the resonance of an agent injected into the circulating blood that allows for assessment of the agent's concentration and determination of the total blood volume. The agent may take a variety of forms, including an agent that is detectable via a non-invasive technique such as ultrasound. The agent may be measured over time and fitting the measurement data to provide an accurate determination of total blood volume.

[Problem] To provide a technique that makes it possible to easily and efficiently select tumor-reactive T cells using an expression molecular marker as an index, while minimizing time, cost and labor. [Solution] The problem is solved by a method for producing tumor-reactive T cells, the method being characterized by comprising: (1) a candidate isolation step for isolating CD8-positive T cells from tumor-infiltrating lymphocytes (TIL) or whole blood obtained from a cancer patient, using, among antibodies found on the cell surfaces, PD-1 and / or 4-1BB as markers; (2) a tumor reactivity evaluation step for transducing a T cell receptor (TCR) gene of the T cells isolated in the candidate isolation step into T cells and identifying and evaluating a TCR having tumor reactivity; and (3) a treatment T cell acquisition step for proliferating T cells that react with a tumor in vitro to obtain tumor treatment T cells to be administered to the cancer patient.

To provide a composition that can promote the production of IL-10 in intestinal epithelial cells. [Solution] A composition containing dead lactic acid bacteria belonging to the genus Lactiplantibacillus, which has an effect of promoting IL-10 production in intestinal epithelial cells, promotes the production of IL-10, an anti-inflammatory immune-related cytokine, in intestinal epithelial cells, thereby increasing or suppressing the decrease in blood IL-10 concentration, preventing or improving liver function decline, preventing or improving cholestasis, reducing total blood cholesterol or LDL cholesterol, promoting the polarization of macrophages from M1 to M2, or suppressing the decline in skin barrier function.