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Method for preparing modified regenerated cellulose/alginate hemostatic composite material

A technology of regenerated cellulose and regenerated cellulose sodium, applied in the field of biomedical composite materials, can solve the problems of low mechanical strength and stability, unsatisfactory hemostatic effect, etc., to promote the formation of prothrombin activator and improve the structural integrity Sex, the effect of accelerating the process of hemostasis

Active Publication Date: 2014-09-03
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a modified regenerated cellulose / alginate hemostatic composite material in order to solve the technical problems of unsatisfactory hemostatic effect, structural integrity, low mechanical strength and stability of the existing alginate materials. Preparation

Method used

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  • Method for preparing modified regenerated cellulose/alginate hemostatic composite material
  • Method for preparing modified regenerated cellulose/alginate hemostatic composite material
  • Method for preparing modified regenerated cellulose/alginate hemostatic composite material

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specific Embodiment approach 1

[0018] Embodiment 1: The preparation method of the modified regenerated cellulose / alginate hemostatic composite material in this embodiment is carried out according to the following steps:

[0019] 1. Preparation of oxidized regenerated cellulose sodium / sodium alginate aqueous solution: mix oxidized regenerated cellulose sodium and sodium alginate powder with a mass ratio of 1 to 6:9 to form the total mass concentration of oxidized regenerated cellulose sodium and sodium alginate It is a 1.5-5% blend solution, stirred at 30-50°C until uniformly mixed to obtain a mixed aqueous solution of oxidized regenerated cellulose sodium / sodium alginate;

[0020] 2. Forming of hemostatic composite material: Pour the mixed aqueous solution of oxidized regenerated cellulose sodium / sodium alginate into the mold, pre-freeze at -10℃~-20℃ for 40-20 hours, and place the mold in a freeze dryer after the pre-freezing is completed In the process, under the conditions of temperature of -56°C to -20°C...

specific Embodiment approach 2

[0022] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, oxidized regenerated cellulose sodium and sodium alginate powder are formulated into a blend solution in a mass ratio of 2:9. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0023] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in step 1, stir at 40°C until the mixture is uniform. Others are the same as those in the first or second embodiment.

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Abstract

The invention discloses a method for preparing a modified regenerated cellulose / alginate hemostatic composite material, and relates to a method for preparing a hemostatic material, belonging to the technical field of biomedical composite materials. The invention aims to solve the technical problem that an existing alginate material has an unsatisfactory hemostatic effect, poor structure integrity, and relatively low mechanical strength and stability. The method comprises a first step of modification of regenerated cellulose; a second step of preparation of an oxidized regenerated cellulose / sodium alginate water solution; a third step of molding of the hemostatic composite material; and a fourth step of cross-linking and solidification of the hemostatic composite material. According to the modified regenerated cellulose / alginate hemostatic composite material, due to the introduction of a sodium carboxylic acid structure at the C6 site of the regenerated cellulose molecule through the selective oxidization of a TEMPO-NaClO-NaBr oxidation system, the hemostatic property, structure integrity, mechanical strength and stability of the modified regenerated cellulose / alginate hemostatic composite material are improved, and the defects of poor wet strength, low mechanical integrity and easy deformation of ordinary alginate non-woven fabrics are overcome.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic material, belonging to the technical field of biomedical composite materials. Background technique [0002] Alginic acid is a polysaccharide composed of mannuronic and guluronic acids that has been used as a dressing matrix material for decades. As a dressing matrix, alginic acid is highly biocompatible and can absorb a large amount of wound exudate to form a gel, providing a "moist" healing environment for wound healing, protecting the wound surface, reducing the rate of wound infection, and promoting wound healing. Reduce patient discomfort during dressing changes. These superior properties of alginic acid bring broad prospects for its application in medical dressings. [0003] However, pure alginate-based materials suffer from low wet strength and mechanical integrity, poor flexibility, and limited hemostatic performance. Polymer blending or compounding is a common method to solve thes...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/62
Inventor 贺金梅李纪伟黄玉东吴亚东程玮璐李大龙尉枫
Owner HARBIN INST OF TECH
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