Biologic hemostatic powder and preparation method thereof

A hemostatic powder and biological technology, applied in the field of biomedicine, can solve the problems of slow hemostasis and poor hemostatic effect of hemostatic powder, and achieve the effects of preventing thrombus formation, excellent repair function, and promoting healing

Inactive Publication Date: 2018-12-21
FOSHAN SENANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a biological hemostatic powder and its preparation method in view of the poor hemostatic effect and slow hemostatic speed of the current hemostatic powder

Method used

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  • Biologic hemostatic powder and preparation method thereof

Examples

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preparation example Construction

[0019] The preparation method of starch is:

[0020] Take cassava starch and add deionized water according to the mass ratio of 1~3:10~15, heat up to 75~85°C, stir and mix for 1~3h, cool to room temperature, keep vacuum at -60~-50°C for 18~24h, repeat vacuum insulation Process 2~4 times, dry to get starch;

[0021] The preparation method of chelating additive is:

[0022] Take γ-polyglutamic acid and add deionized water according to the mass ratio of 1~5:80~100, heat up to 40~45°C and stir and mix for 20~30min, then add 50~60% chlorinated γ-polyglutamic acid Calcium, stir and mix at 500r / min for 18~24h to obtain the mixture, take the mixture according to the mass ratio of 1~3:8~10, add absolute ethanol, let it stand for 1~3h, take the precipitate, rotary evaporate, freeze-dry, and obtain the chelate additive;

[0023] The preparation method of epidermal growth-stimulating additive is:

[0024] Take collagen and add it into MES buffer with pH5.6 and 5% mass fraction accordi...

Embodiment 1

[0032] The preparation method of starch is:

[0033] Take cassava starch and add deionized water according to the mass ratio of 1:10, heat up to 75°C and mix for 1 hour, cool to room temperature, keep vacuum at -60°C for 18 hours, repeat the vacuum heat preservation process twice, and dry to obtain starch;

[0034] The preparation method of chelating additive is:

[0035] Take γ-polyglutamic acid and add deionized water at a mass ratio of 1:80, heat up to 40°C and stir and mix for 20 minutes, then add calcium chloride with 50% of the mass of γ-polyglutamic acid, and stir and mix at 500r / min for 18 hours. To obtain the mixture, take the mixture and add absolute ethanol at a mass ratio of 1:8, let it stand for 1 hour, take the precipitate and rotary evaporate, and freeze-dry to obtain the chelating additive;

[0036] The preparation method of epidermal growth-stimulating additive is:

[0037]Take collagen and add it into MES buffer solution with pH 5.6 and 5% mass fraction acc...

Embodiment 2

[0045] The preparation method of starch is:

[0046] Take cassava starch and add deionized water according to the mass ratio of 3:15, heat up to 85°C, stir and mix for 3 hours, cool to room temperature, keep vacuum at -50°C for 24 hours, repeat the vacuum heat preservation process 4 times, and dry to obtain starch;

[0047] The preparation method of chelating additive is:

[0048] Take γ-polyglutamic acid and add deionized water at a mass ratio of 5:100, heat up to 45°C and stir and mix for 30 minutes, then add calcium chloride with 60% of the mass of γ-polyglutamic acid, and stir and mix at 500r / min for 24 hours. To obtain the mixture, take the mixture and add absolute ethanol at a mass ratio of 3:10, let it stand for 3 hours, take the precipitate and rotary evaporate, and freeze-dry to obtain the chelating additive;

[0049] The preparation method of epidermal growth-stimulating additive is:

[0050] Take collagen and add it into MES buffer solution with pH5.6 and 5% mass ...

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Abstract

The invention discloses biologic hemostatic powder and a preparation method thereof, which belongs to the field of biological medicine. Cassava starch is used as a raw material to form a loose porousstructure, coagulation of blood platelets can be accelerated, the blood coagulation can be promoted, and the hemostatic time can be shortened; gamma-polyglutamic acid and calcium chloride are used asraw materials to be chelated with calcium ions to prepare chelate additive gamma-polyglutamic acid on a bleeding site, and the existence of the calcium ions on a wound can further accelerate the bloodcoagulation; collagen is mixed a cross-linking agent genipin to combine heparin sodium and collagen to obtain an epidermal growth promotion additive, the healing and cell activation rebuilding of a bleeding wound can be promoted, and the restoration function is excellent; and chitosan and dodecyl aldehyde are added to generate Schiff base, so that the probability of mesoporous additive remainingin blood can be reduced, the safety performance can be ensured, and the irritation action for the wound can be reduced. The problems that the existing hemostatic powder is poor in hemostatic effect and low in hemostatic speed can be solved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a biological hemostatic powder and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of wounds and foreign bodies, and play an import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L24/02A61L24/04A61L24/10
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/046A61L24/08A61L24/102A61L24/108A61L2300/236A61L2300/412A61L2300/414A61L2300/418A61L2300/42A61L2400/04C08L3/02C08L77/04
Inventor 胡次兵路芸卢星
Owner FOSHAN SENANG BIO TECH CO LTD
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