Water-soluble oxidized regenerated cellulose hemostatic material and preparation method thereof

Abstract

The invention relates to a water-soluble oxidized regenerated cellulose hemostatic material and a preparation method thereof, solving the problem that the traditional oxidized regenerated cellulose materials are water-insoluble and have the defects of high polymerization degree, poor biological absorbability and slow haemostatic speed. The water-soluble oxidized regenerated cellulose hemostatic material is prepared from an alcoholic solution of oxidized regenerated cellulose and strong alkali. The preparation method comprises the following steps of: (1) neutralizing and modifying; (2) washing; and (3) drying. The product provided by the invention can be used in the medical hemostasis field.

Description

technical field

[0001] The invention relates to an oxidized regenerated cellulose hemostatic material and a preparation method thereof. Background technique

[0002] Oxidized regenerated cellulose products mainly use regenerated cellulose as raw material, and carry out selective oxidation of the primary hydroxyl position through suitable oxidants, such as gas phase or liquid phase nitrogen dioxide and TEMPO system, to obtain carboxyl content of 16% to 24%. The oxidized regenerated cellulose is obtained through washing, drying, disinfection, sealing and sterilization, and the corresponding medical hemostatic products can be obtained. The most widely used product of this type is the SURGICEL series of absorbable hemostatic products produced by Johnson&Johnson——SURGICEL TM 、SURGICEL TM Nu-Knit, SURGICEL TM Fibrillar, the ingredients of this series of products are all oxidized regenerated cellulose, the main difference is reflected in the external form.

[0003] Oxidized r...