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Preparation method for zeolite-containing hemostatic gel dressing

A technology of hemostatic gel and zeolite, which is used in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as increasing the difficulty of cleaning wounds for doctors, patient pain, and blood vessel blockage, and achieves optimization of pore-forming effect, promotion of cross-linking reaction, and hemostasis. The effect of shortening time

Active Publication Date: 2017-10-20
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the external hemostatic products currently on the market are zeolite hemostatic powder. When in use, zeolite hemostatic powder can be directly sprinkled on the wound, but it has the following disadvantages: first, directly sprinkle zeolite on the patient's wound, because zeolite will absorb water and release it. Second, zeolite is directly sprinkled on the wound, and it needs to be cleaned up after hemostasis, which not only increases the difficulty for doctors to clean up the wound, but also the remaining wound remains Zeolite particles may cause clogged blood vessels

Method used

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  • Preparation method for zeolite-containing hemostatic gel dressing
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  • Preparation method for zeolite-containing hemostatic gel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of Hemostatic Gel Dressing Containing Zeolite

[0024] Step 1: Take 10 mL of a water-soluble human-like collagen solution with a mass concentration of 100 mg / mL, add zeolite at a mass ratio of zeolite to water-soluble human-like collagen of 1:10, and then add a cross-linking agent with a concentration of 1% β-diimide zinc complex and 1,2,7,8-diepoxyoctane each 1 mL, then add 10mg / mL KCl 2mL, mix well, and adjust the pH of the solution with dilute hydrochloric acid and sodium hydroxide solution 4.5;

[0025] Step 2: Dispense the mixed solution in step 1 into a mold, keep it at 50°C for 2h, then transfer it to a high-pressure steam sterilizer and keep it at 121°C for 20min to obtain the initial gel;

[0026] Step 3: Soak and wash the preliminary gel in Step 2 for 5 days in distilled water, change the washing water every 6 hours to remove salt and residual crosslinking agent; transfer the washed preliminary gel to the autoclave to continue Keep it at 121°C...

Embodiment 2

[0030] Example 2 Preparation of Hemostatic Gel Dressing Containing Zeolite

[0031] Step 1: Take 10 mL of a water-soluble human-like collagen solution with a mass concentration of 200 mg / mL, add zeolite at a mass ratio of zeolite to water-soluble human-like collagen of 1:15, and then add a crosslinking agent with a concentration of 1% β-diimide zinc complex and 1,2,7,8-diepoxyoctane each 2 mL, then add 10mg / mL Na 2 SO 4 2mL, mix well, and adjust the pH of the solution to 4 with dilute hydrochloric acid and sodium hydroxide solution;

[0032] Step 2: Dispense the mixed solution in step 1 into a mold, keep it in a 60°C water bath environment for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 110°C for 30 minutes to obtain the initial gel;

[0033] Step 3: Soak and wash the preliminary gel in Step 2 for 5 days in distilled water, change the washing water every 6 hours to remove salt and residual crosslinking agent; transfer the washed preliminary gel to th...

Embodiment 3

[0036] Example 3 Preparation of Hemostatic Gel Dressing Containing Zeolite

[0037] Step 1: Take 10 mL of a water-soluble human-like collagen solution with a mass concentration of 400 mg / mL, add zeolite at a mass ratio of zeolite and water-soluble human-like collagen of 1:20, and then add a cross-linking agent with a concentration of 1% 4 mL each of β-diimide zinc complex and 1,2,7,8-diepoxyoctane, then add 10mg / mL NaCl 2mL, mix well, and adjust the pH of the solution with dilute hydrochloric acid and sodium hydroxide solution 5;

[0038] Step 2: Dispense the mixed solution in step 1 into a mold, keep it in a 70°C water bath environment for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 121°C for 15 minutes to obtain a gel product;

[0039] Step 3: Soak and wash the preliminary gel in Step 2 for 5 days in distilled water, change the washing water every 6 hours to remove salt and residual crosslinking agent; transfer the washed preliminary gel to the aut...

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Abstract

The invention relates to a preparation method for a porous zeolite-containing hemostatic gel dressing based on human-like collagen and zeolite. According to the weight ratio (1:10) to (1:20) of zeolite to human-like collagen, an appropriate amount of zeolite is added into LHC solution to obtain a mixture, inorganic salt, zinc beta-diiminate complex as a compound cross-linking agent and 1,2,7,8-diepoxyoctane are added into the mixture and uniformly stirred, the pH value of the solution is regulated to the acidic condition, the solution is put into 40 DEGC-80 DEG C water bath and kept for 0.5 to 5 hours, high-temperature vapor treatment and washing are then carried out twice to remove salt and cross-linking agent residues, and after drying and Co-60 sterilization, the zeolite-containing hemostatic gel dressing is obtained. The material has good air permeability, adhesion resistance and a quick hemostatic effect, moreover, the gel medium disperses the zeolite particles, so that the problem of heat release of the zeolite in the process of exerting the hemostatic effect is greatly mitigated, and compared with gel without zeolite, the porous zeolite-containing hemostatic gel dressing remarkably shortens the hemostatic time to 15 to 25 seconds on average.

Description

Technical field [0001] The invention relates to a preparation method of a zeolite-containing hemostatic gel dressing, belonging to the technical field of medical hemostatic materials. Background technique [0002] Zeolite is a general term for porous hydrated aluminosilicate crystals with a framework structure. Zeolite has a strong framework structure, there are cavities, pores and other large-volume voids inside. At the same time, there are many uniformly sized micropores and channels inside the crystal lattice, which can account for more than 50% of the volume of the zeolite. The pores and channels are connected to each other, giving the zeolite a huge surface area. Therefore, zeolite has a high water absorption rate and water absorption. When zeolite is used in a hemostatic material, it can absorb water in the blood, condense platelets and clotting factors, and achieve the purpose of hemostasis. The use of zeolite hemostatic dressings has been widely accepted. However, it is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/24C08L89/00
CPCA61L26/0004A61L26/0033A61L26/008A61L26/0085A61L2400/04C08J3/243C08J2389/00C08L89/06
Inventor 范代娣惠俊峰段志广郑晓燕李伟娜姜西娟
Owner NORTHWEST UNIV(CN)
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