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Graphene oxide grafted modified oxidized regenerated cellulose hemostatic material and preparation method thereof

A technology of regenerated cellulose and graft modification, applied in medical science, bandages, absorbent pads, etc., can solve the problems of small improvement in hemostatic performance, poor mechanical strength and biological absorption, and achieve the effect of reducing hemostasis time

Active Publication Date: 2015-03-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problems of existing modified materials of oxidized regenerated cellulose, such as poor mechanical strength and bioabsorption, and small improvement in hemostatic performance, and to provide a graphene oxide grafted modified oxidized regenerated cellulose Hemostatic material and preparation method thereof

Method used

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specific Embodiment approach 1

[0025] Specific embodiment 1: This embodiment is a graphene oxide grafted modified oxidized regenerated cellulose hemostatic material prepared from graphene oxide and oxidized regenerated cellulose containing amino groups on the surface; the surface contains amino groups The mass ratio of graphene oxide to oxidized regenerated cellulose is (0.01~3):100.

[0026] The graphene oxide described in this embodiment is oxidized by the Hummers method, and then washed, dried, and ground to obtain the oxidation product; then the oxidation product is added to N,N-dimethylformamide and ultrasonic After treatment, use a rotary evaporator to remove N,N-dimethylformamide to obtain graphene oxide.

[0027] In this embodiment, the amino groups in the graphene oxide containing amino groups on the surface and the carboxyl groups in the oxidized regenerated cellulose structure react to form an amide bond, thereby branching the graphene oxide to the oxidized regenerated cellulose.

[0028] Advantages of...

specific Embodiment approach 2

[0032] Specific embodiment two: this embodiment is different from specific embodiment one in that: the carboxyl content in the oxidized regenerated cellulose is 16%-24%; the oxidized regenerated cellulose is made of short filaments, filaments or fabrics. The form exists. The other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0033] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the method for preparing graphene oxide containing amino groups on the surface is completed in the following steps:

[0034] 1. Preparation of acyl chlorinated graphene oxide: ①. Add graphene oxide to N,N-dimethylformamide, then ultrasonically treat 15min~60min under the ultrasonic power of 160W~400W, then add thionyl chloride , Stir for 16h~48h at a temperature of 60℃~100℃ and a stirring speed of 300r / min~750r / min, then cool to room temperature naturally, and then use a rotary evaporator for rotary evaporation to obtain mixture A; ②, Using dichloromethane as a cleaning agent, use a rotary evaporator to rotate the mixture A; ③, repeat step 1 ② 2 to 6 times to obtain acylated graphene oxide;

[0035] The volume ratio of the mass of graphene oxide described in step one to the volume of N,N-dimethylformamide is (0.004g~0.05g): 1mL;

[0036] The volume ratio of the mass of graphene oxide to thionyl...

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Abstract

The invention discloses a graphene oxide grafted modified oxidized regenerated cellulose hemostatic material and a preparation method thereof, relating to a hemostatic material and a preparation method thereof. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material aims to solve the problems that a modified material of the existing oxidized regenerated cellulose is poor in mechanical strength and biological absorption of the material and small in improvement degree of hemostatic performance. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material is prepared from graphene oxide containing amino groups on the surface and oxidized regenerated cellulose. The preparation method comprises the following steps: I, preparing graphene oxide subjected to acylating chlorination; II, preparing graphene oxide containing the amino groups; and III, performing chemical grafting to obtain the graphene oxide grafted modified oxidized regenerated cellulose hemostatic material. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material disclosed by the invention can be used for reducing the bleeding-stopping time by 7-17% when the material is used for stopping bleeding. The graphene oxide grafted modified oxidized regenerated cellulose hemostatic material and the preparation method thereof can be obtained according to the invention.

Description

Technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] Various accidents inevitably occur in daily life. During emergency treatment and surgery, hemorrhage may lead to medical accidents and even death. Therefore, local and effective rapid hemostasis in patients is very important, and effective control of bleeding and reducing bleeding time have become important measures to reduce patient mortality. Commonly used clinical hemostatic materials such as hemostatic gauze, hemostatic fibers, and hemostatic bandages have their limitations in use. For example, the hemostasis time is long, it is easy to adhere to the wound and is not easy to change the dressing, and it can do nothing for wound infection and suppuration. Rapid hemostasis and functional hemostasis will be the direction of the future development of hemostatic drugs. [0003] Commonly used absorbable hemostatic materials include fibrin glue, gelati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/44
Inventor 吴亚东黄玉东贺金梅王芳
Owner HARBIN INST OF TECH
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