Medical flocking hemostasis material, preparation thereof and application

A hemostatic material and flocking technology, applied in the field of flocking medical materials, can solve the problems of affecting the hemostatic effect, loss, difficult to control, etc.

Active Publication Date: 2012-07-25
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various powdered hemostatic materials (including fiber powder and microporous microspheres) have the characteristics of particles. When applied to the bleeding site, the p

Method used

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  • Medical flocking hemostasis material, preparation thereof and application
  • Medical flocking hemostasis material, preparation thereof and application
  • Medical flocking hemostasis material, preparation thereof and application

Examples

Experimental program
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Effect test

Embodiment 1

[0065]Sample preparation: (1) Preparation of flocking hemostatic sponge: Dissolve 3g of sodium alginate in 100ml of water, stir evenly, adjust the pH to 6.0, inject about 40ml of the solution into the mold to obtain a liquid-absorbing layer, the liquid-absorbing The layer is gel-like; 2g chitosan and 2g collagen are dissolved in 100ml of aqueous solution containing 3% acetic acid (volume percentage concentration) respectively, then the two solutions are mixed, stirred evenly, and the pH value is adjusted to 6.0 to obtain a mixed solution. Gently inject about 30ml of the mixed solution into the surface of the liquid-absorbing layer in the mold to obtain a hemostatic layer. The hemostatic layer is gel-like; the upper surface of the hemostatic layer is flocked by electrostatic flocking, and the length of the fluff is about 1 mm. , the fineness is 1.5-4.5dtex, the fluff components are medical chitosan fibers and collagen fibers, and the flocking amount is 5mg / cm 2 After flocking, ...

Embodiment 2

[0083] (1) Preparation of flocking hemostatic material: Dissolve 2g of collagen in 100ml of an aqueous solution containing 3% acetic acid (volume percentage concentration), and add glutaraldehyde dropwise while stirring until the final concentration of glutaraldehyde is 0.05% (volume percentage concentration). Concentration), adjust the pH value to be 6.0, inject the solution of about 40ml in the mold to get the gel base layer; adopt the mechanical flocking method to flock on the upper surface of the base layer, the hair length is about 2 mm, and the fineness is 2.0-4.5dtex, the fluff is collagen fibers, and the final flocking amount is 8.0mg / cm 2 , 0.5% acetic acid (volume percentage concentration) aqueous solution ultrasonic atomization spray (cross-linking agent), flocking is completed using 36 to 40 hours of freeze-drying to obtain the flocked hemostatic sponge of this embodiment. Among them, when performing mechanical flocking, the functional fibers are first cut into 2mm...

Embodiment 3

[0097] (1) Preparation of flocking hemostatic film: dissolve 1.5g sodium alginate and 1.5g carboxymethyl cellulose in 100ml water, stir evenly, adjust the pH value to 6.0, inject about 40ml of the solution into the mold, and absorb Liquid layer, the liquid-absorbing layer is gel-like; Dissolve 2g chitosan and 2g gelatin in 100ml aqueous solution containing 3% acetic acid (volume percentage concentration) respectively, mix the two solutions, add dropwise while stirring Glutaraldehyde to glutaraldehyde final concentration is 0.05% (volume percentage concentration), adjusts the pH value to be 6.0, gently injects the mixed solution of about 40ml into the surface of the liquid-absorbing layer in the mould, obtains the hemostatic layer, and this hemostatic layer is the coagulation layer. Colloidal; the upper surface of the hemostatic layer is flocked by electrostatic flocking method, the length of the fluff is about 5mm, the fineness is 2.0-5.5dtex, the fluff component is a blended f...

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Abstract

The invention relates to a medical flocking hemostasis material for stopping bleeding and protecting arteries, veins and wounds of tissues, application of the medical flocking hemostasis material and a method for preparing the medical flocking hemostasis material. The medical flocking hemostasis material comprises a flocking layer and a base layer, the flocking layer is used as a wound contacting layer and made of functional fibers, and the functional fibers are fixed on the upper surface of the base layer in a flocking method. The flocking method comprises a mechanical flocking method and an electrostatic flocking method. The medical flocking hemostasis material can be used for stopping bleeding and protecting the arteries, the veins and the wounds of the tissues, and further can be used as a medicine slow-release carrier. The invention further discloses method for controlling bleeding of the arteries, bleeding of the veins and bleeding of the wounds of the tissues by the aid of the medical flocking hemostasis material. Compared with a hemostasis material in the prior art, the medical flocking hemostasis material has the advantages that a hemostasis performance, comfortableness and the like are greatly improved.

Description

technical field [0001] The invention relates to a flocking medical material used for hemostasis and protection of arteries, veins and tissue wounds, its application and a method for preparing the flocking medical material. Background technique [0002] Usually, in the case of normal blood coagulation function of human blood itself, general tissue trauma can self-repair, superficial bleeding or venous bleeding can self-coagulate, however, arterial bleeding, large venous bleeding, more serious tissue trauma or most During surgical operations, the blood cannot self-coagulate in time and achieve the function of self-protection. If measures are not taken in time, it will lead to severe bleeding, and excessive blood loss is often life-threatening. Especially in various situations such as battlefields, wild accidents, earthquake-like natural disasters, and surgical operations, it is particularly important to use fast and effective hemostatic materials. [0003] In recent years, mo...

Claims

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Application Information

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IPC IPC(8): A61F13/00A61L15/42A61K47/36A61K47/42A61K47/34A61K47/04
Inventor 吴昌琳
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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