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Hemostatic material

A hemostatic material and fiber technology, applied in the field of hemostatic materials, can solve the problems of insufficient fiber absorption, no antibacterial performance, harsh reaction conditions, etc., and achieve good liquid absorption performance and antibacterial performance, good vertical absorption performance, and reaction conditions mild effect

Active Publication Date: 2017-01-04
JIANGSU NEWVALUE MEDICAL PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these modification methods, on the one hand, have harsh reaction conditions, cumbersome steps, and are not easy to control; on the other hand, the distribution position and quantity of substituents on the molecular chain of the product obtained from the reaction are uncertain, making it difficult to effectively control the liquid absorption performance of the product.
In addition, the above products do not have antimicrobial properties either
These problems will greatly limit the clinical application of dressings prepared from chitin fibers, especially in the treatment of burns and chronic wounds.
[0005] In particular, in the past chitin fibers, people often control the liquid absorption performance of the fiber by controlling the degree of substitution, but the inventors of the present invention found that if the substitution is too low, the liquid absorption of the fiber is insufficient, and if the substitution is too high, Although the liquid absorption is significantly increased, the fiber shape is difficult to maintain, that is, the fibers will be dissolved or dispersed by the absorbed liquid
At this time, the outflow of liquid will cause a certain degree of loss of suction function.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.25, disperse them in 50 mL of isopropanol, add 2.54 g of 2-hydroxyethyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.0, soak for 1 hour, and then separate the soaked fiber from the mixture , washed 3 times with 80% (v / v) methanol aqueous solution, dehydrated, and dried at 40°C to obtain a liquid-absorbent fiber with a viscosity-average molecular weight (Mη) of 3 million and a degree of substitution of acryl group total substance of 0.17.

[0113] Dissolve absorbent fibers ...

Embodiment 2

[0115] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.10, disperse them in 50 mL of isopropanol, add 7.09 g of 2-hydroxypropyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.0, soak for 1 hour, and then separate the soaked fiber from the mixture , washed three times with 80% (v / v) methanol aqueous solution, dehydrated, and dried at 40°C to obtain a liquid-absorbent fiber with a viscosity-average molecular weight of 3 million and a degree of substitution of acryl group total substance of 0.30.

[0116] Dissolve absorbent fibers ...

Embodiment 3

[0118] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.10, disperse them in 80 mL of isopropanol, add 14.17 g of 2-hydroxypropyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.5, soak for 1 hour, and then separate the soaked fiber from the mixture , shake dry, and place in saturated CaCl 2 Soak in the solution for 1 hour, take out the fiber, wash 3 times with 80% (v / v) methanol aqueous solution, and dry at 40°C after dehydration to obtain a viscosity-average molecular weight of 500,000 and a total substitution degree of acryloyl...

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Abstract

The invention aims to provide fiber suitable for clinical application, in particular to the application of hemostasis, scalding, chronic wound treatment and others. The invention is a hemostatic material, wherein the hemostatic material includes fiber, and the material is possessed of biodegradability; the hemostatic material is characterized in that the fiber includes a polymer expressed by the following structural formula: FORMULA, wherein R is at least one of groups consisting of -NH2, -CH2CH20H, -OCH2CH2CH2OH, -OH, -ONa, -OK, -OCa; m, n and p respectively represent the quantity percent of corresponding repeat unit in the polymer molecule and can meet the following relationship formula: m+n+p=1, p / (m+n+p)=0.05-0.30; the degree of substitution D is defined as m / (m+n+p), the total degree of substitution of fiber is defined as Ds, and the degree of substitution of polymer at the center of the fiber cross section is defined as D0; when the degree of substitution of the edge of the fiber cross section is defined as D, the following relationship formula can be satisfied: Ds=0.09-0.8, Do / D=0-0.7.

Description

technical field [0001] The present invention relates to a hemostatic material, in particular, to a hemostatic material comprising fibers capable of absorbing liquid through swelling, and the material can be degraded in the human body. Background technique [0002] Chitin has good biocompatibility, biodegradability, hemostasis, and promotion of wound healing, making it suitable for various tissue engineering scaffold materials such as absorbable surgical sutures, wound dressings, drug carrier materials, and artificial skin has broad application prospects. [0003] Chitin is dissolved in organic acid or inorganic acid to form a viscous colloid. After spinning, coagulation, washing, drying and other processes, chitin fibers can be obtained, which can be used to prepare wound dressings. Chinese patent document CN1129748A (deacetylated chitosan fiber and its manufacturing method and application), Chinese patent document CN1149093A (chitin fiber and its preparation method), Chine...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L24/00A61L24/08D01F9/00
CPCA61L15/28A61L15/42A61L15/44A61L24/001A61L24/08A61L2300/232A61L2400/04D01F9/00C08L5/08
Inventor 周应山徐礼勤龚祖光杨柳清王立平蒋锐
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
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