Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof

A technology of combining alkyl chitosan and graphene, which is applied in the field of medical materials, can solve the problems such as the decline of blood absorption performance, and achieve the effects of shortening hemostasis time, reducing blood loss, and enhancing blood absorption capacity.
CN109966544AActive Publication Date: 2019-07-05INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
Publication Date
2019-07-05

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to alkyl chitosan-graphene oxide composite sponge and a preparation method and application thereof. The composite sponge comprises alkyl chitosan and graphene oxide adsorbed on alkyl chitosan, and adsorption capacity of graphene oxide is 3-28%. The composite sponge obtained by taking alkyl chitosan as a matrix and compositing graphene oxide and alkyl chitosan has excellent hemostatic performance and blood absorbing capacity. Embodiment results show that when the composite sponge is used for hemostasis,in-vitro whole blood coagulation time is less than 58s, hemostasis time of a rabbit femoral artery bleeding model is less than 155s, bleeding amount is less than 5.4g, and hemostasis effect is betterthan pure alkyl chitosan sponge or graphene oxide powder.
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Description

technical field

[0001] The invention belongs to the technical field of medical materials, and in particular relates to an alkyl chitosan-graphene oxide composite sponge and its preparation method and application. Background technique

[0002] Excessive blood loss is one of the main causes of death in battlefields and accidents. Therefore, the design and development of a safe and efficient hemostatic material has always been one of the hot spots that people pay attention to.

[0003] Chitosan is a positively charged natural polymer with good biocompatibility, mucoadhesion, antibacterial and hemostatic properties, but its hemostatic effect on acute massive bleeding wounds is not stable, so it is necessary to The polysaccharide material was modified to further enhance its hemostatic properties. Studies have shown that grafting a certain amount of alkyl groups on chitosan amino groups can effectively improve the hemostatic properties of chitosan, but compared with ungrafted chi...

Claims

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