Nanogold/lysine/oxidized regenerated cellulose composite hemostatic material and preparation method thereof

A technology of regenerated cellulose and hemostatic materials, applied in the field of hemostatic materials and their preparation, can solve the problems of low hemostatic performance improvement and hindering material bioabsorption, and achieve the effect of reducing hemostatic time

Active Publication Date: 2015-03-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that existing modified oxidized regenerated cellulose is used as a hemostatic material, and mammalian skin and other body cells in the contact point are irritated, and a large whitish granulation mass is formed at the position of use. , hinder the bioabsorption of the material and the problem of low hemostatic performance improvement, and provide a nano-gold / lysine / oxidized regenerated cellulose composite hemostatic material and its preparation method

Method used

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0022] Specific Embodiment 1: This embodiment is a composite hemostatic material of nano gold / lysine / oxidized regenerated cellulose prepared from nano gold and oxidized regenerated cellulose grafted with lysine on the surface; the nano gold and the surface The mass ratio of the oxidized regenerated cellulose grafted with lysine is (0.01-0.5):100.

[0023] The advantage of this implementation mode:

[0024] 1. This embodiment aims to propose a more suitable method to modify oxidized regenerated cellulose on the basis of maintaining the advantages of the oxidized regenerated cellulose absorbable hemostatic material; the advantage of this embodiment is that the surface of the oxidized regenerated cellulose material Physical adsorption of nano-gold particles, thereby improving the hemostatic performance of the material, without damaging the mechanical strength of oxidized regenerated cellulose, and ensuring the bioabsorbability of oxidized regenerated cellulose;

[0025] 2. Using...

specific Embodiment approach 2

[0027] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the preparation method of oxidized regenerated cellulose grafted with lysine on the surface is specifically completed according to the following steps:

[0028] Immerse oxidized regenerated cellulose to a concentration of 1.0 × 10 -4 g / mL~9.0×10 -4 g / mL lysine aqueous solution, and then use an oscillator to vibrate for 1h to 48h to obtain oxidized regenerated cellulose soaked in lysine aqueous solution; immerse the oxidized regenerated cellulose soaked in lysine aqueous solution into absolute ethanol 4h to 24h, and then washed with absolute ethanol for 5 to 8 times, and then vacuum-dried at a temperature of -70 to -20°C for 24h to 72h to obtain oxidized regenerated cellulose grafted with lysine on the surface;

[0029] The carboxyl content in the oxidized regenerated cellulose is 16% to 24%;

[0030] The quality and concentration of the oxidized regenerated cellulose are 1....

specific Embodiment approach 3

[0031]Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the oxidized regenerated cellulose exists in the form of short filaments, filaments or fabrics. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a nanogold/lysine/oxidized regenerated cellulose composite hemostatic material and a preparation method thereof, relates to a hemostatic material and a preparation method thereof, and aims at solving the problems of obstruction to the biological absorption of a hemostatic material and slight improvement of the hemostatic performance due to a fact that the skin of a mammal is irritant to other body cells at a contact position and a large whitish granulation lump is formed at a use position in the use process of an existing oxidized regenerated cellulose modified material serving as the hemostatic material. The nanogold/lysine/oxidized regenerated cellulose composite hemostatic material is prepared from the nanogold and the oxidized regenerated cellulose on the surface of which the lysine is grafted; the preparation method of the hemostatic material comprises the steps of firstly, chemically grafting the lysine to the oxidized regenerated cellulose, secondly, preparing the aqueous dispersion of the nanogold, and 3, carrying out self-assembling of the nanogold, thereby obtaining the nanogold/lysine/oxidized regenerated cellulose composite hemostatic material. The invention successfully provides the nanogold/lysine/oxidized regenerated cellulose composite hemostatic material and the preparation method thereof.

Description

technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] Various accidents inevitably occur in daily life. During emergency treatment and operation, medical accidents or even death may be caused by massive bleeding. Therefore, local and effective rapid hemostasis of patients is very important, and effective control of bleeding and reducing bleeding time have become important measures to reduce the mortality of patients. Commonly used clinical hemostatic materials such as hemostatic gauze, hemostatic fiber, and hemostatic bandage have limitations in use, such as longer hemostasis time, easy adhesion to the wound and difficult dressing change, and powerlessness to wound infection and suppuration. Rapid hemostasis and functional hemostasis will be the development direction of hemostatic drugs in the future. [0003] Commonly used absorbable hemostatic materials include fibrin glue, gelatin sponge, ox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/20
Inventor 吴亚东黄玉东贺金梅王芳
Owner HARBIN INST OF TECH
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