The invention relates to health-care medicinal liquor capable of tonifying the kidney, strengthening yang and enhancing immunity and a preparation method thereof. The medicinal liquor is characterized by being prepared by soaking the following traditional Chinese medicines with white spirit: wild ginseng, cordyceps sinensis, pilose antler powder, deer penis, deer tendons, sea otters, hippocampus japonicus, gecko, glossy ganoderma, herba epimedii, cistanche deserticola, saffron crocus, dogwood, morinda officinalis, rehmanniae praeparatum, schisandra chinensis, gastrodia elata, cinnamomum cassia, rhizoma cibotii, fructus psoraleae, rape pollen, fructus ziziphi jujubae, the bark of eucommia, radix astragali powder and medlar. According to the theory of the traditional Chinese medicine that the kidney is the root of congenital constitution, the health-care medicinal liquor is mainly used for tonifying the kidney and strengthening yang. The medicinal liquor is prepared by adopting a fine scientific technology and carrying out four times of soaking, filtration, preparation and ageing on 20 various of precious traditional Chinese medicines which are capable of prolonging the life span ofhuman body cells. The medicinal liquor has a good effect and specific functions of enhancing of physical strength and sexual function when being drunk, and is particularly suitable for crowns with diseases such as deficiency of the kidney, impotence, premature ejaculation, lumbago, lacking in strength, prematurely senile and the like.