Polysaccharide hemostatic dressing as well as preparation method and application thereof

A technology of hemostatic dressing and polysaccharide, which is applied in the field of medicine and biology, can solve the problems of limited functional effect of chitosan and unsatisfactory dressing effect, and achieve the effects of shortening the hemostatic time, significant hemostatic effect, and good biocompatibility

Inactive Publication Date: 2019-02-22
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These reports usually make chitosan into water-insoluble chitosan powder, chitosan film, chitosan sponge, chitosan fiber and fabric, etc., but due to the limited functional effect of chitosan itself, the prepared The effect of the dressing is not ideal, and chitosan needs to be used in combination with other materials to improve the overall performance of the dressing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of oxidized starch

[0012] Weigh 15g of starch, put it into a 500ml glass triangular flask, add 200ml of water, heat and stir to dissolve, adjust the pH value to pH5.5 with 5% (weight percentage, the same below) acetic acid aqueous solution, add the oxidant NaIO 4 3.5g, seal, and stir oxidation reaction at room temperature for 24h in the dark. After the reaction was completed, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, protected from light, and dialyzed with distilled water at 4°C for 24 hours, wherein the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 13.5 g of oxidized starch containing dialdehyde groups, and the percentage content of dialdehyde groups was 12.5% ​​(the percentage content of dialdehyde groups refers to polysaccharide The percentage of sugar units containing dia...

Embodiment 2

[0013] Embodiment 2: the preparation of oxidized carboxymethyl cellulose

[0014] Weigh 15g of carboxymethyl cellulose powder, add it to a 1000ml glass conical flask, add 800ml of water, stir to dissolve, adjust the pH value to pH5.5 with 5% acetic acid aqueous solution, add the oxidizing agent KIO 4 8g, seal, and stir the oxidation reaction at room temperature for 60h in the dark. After the reaction is completed, add 4 times the volume of 95% ethanol aqueous solution under stirring, precipitate, and filter the precipitate with suction, wash 3 times with 95% ethanol aqueous solution, dehydrate with absolute ethanol, and dry in vacuo to obtain dialdehyde group-containing oxidized carboxyl Methylcellulose 12.1g, its dialdehyde percentage content is 62.5%.

Embodiment 3

[0015] Embodiment 3: the preparation of oxidized alginic acid

[0016] Weigh 15g of sodium alginate, add it to a 1000ml glass conical flask, add 800ml of water, stir to dissolve, adjust the pH value to pH5.0 with 1mol / L hydrochloric acid aqueous solution, add oxidant KIO 4 9g, seal, and stir the oxidation reaction at 4°C for 36h in the dark. After the reaction was completed, the reaction solution was put into a dialysis bag with a molecular weight cut-off of 3000 Daltons, protected from light, and dialyzed with distilled water at 4°C for 24 hours, wherein the distilled water was replaced every 6 hours. After the dialysis, the liquid in the dialysis bag was freeze-dried in a freeze dryer for 48 hours to obtain 13 g of oxidized sodium alginate containing dialdehyde groups, and the percentage content of dialdehyde groups was 48.5%.

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PUM

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Abstract

The invention discloses a polysaccharide hemostatic dressing as well as a preparation method and an application thereof. The polysaccharide hemostatic dressing is membrane or sponge-like product prepared by carrying out a cross-linking reaction on aminopolysaccharides and oxidized polysaccharides, wherein the aminopolysaccharides refer to one or more of hyaluronic acid, chondroitin sulfate, heparin, chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, sulfonated chitosan, hydroxybutyl chitosan, carboxymethyl chitosan, succinyl chitosan or other chitosan derivatives; the oxidized polysaccharides refer to one or more of oxidized polysaccharides containing dialdehyde groups; and saccharide units containing the dialdehyde groups account for 1-70% of total saccharide units of the polysaccharide molecule. The polysaccharide hemostatic dressing disclosed by the invention has an obvious hemostasis effect, is capable of obviously shortening the hemostasis time of the wound surface, is non-toxic, and has excellent biocompatibility. The polysaccharide hemostatic dressing can be used for preparing medical apparatuses and instruments for traumatic hemostasis and surgical hemostasis, servesas hemostatic dressing medical apparatuses and instruments to be developed, and has wide market prospects.

Description

technical field [0001] The invention relates to a polysaccharide biological material, in particular to a polysaccharide hemostatic dressing and its preparation method and application, belonging to the field of medical biotechnology. Background technique [0002] Clinically used medical dressings generally include hydrogel dressings, film dressings, sponge dressings, and powder dressings. Film dressings and sponge dressings often have good mechanical properties, can cover wounds, block microorganisms, and provide gas exchange. An ideal hemostatic dressing needs to have rapid hemostasis and healing-promoting properties, and at the same time have good liquid absorption and tissue compatibility, be able to cover the wound, protect the wound, and accelerate wound healing. Multifunctional hemostatic dressing has been the main research direction of hemostatic materials at home and abroad. [0003] Clinical hemostatic dressings mainly include hemostatic dressing products derived f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/42
CPCA61L15/20A61L15/28A61L15/42A61L2300/252A61L2300/418A61L2400/04
Inventor 韩宝芹彭燕飞蒋志雯常菁杨艳
Owner OCEAN UNIV OF CHINA
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