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Application of mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora

A technology for regulating intestinal flora and extracts, applied in the field of traditional Chinese medicine, can solve problems such as no report on the regulation effect of jelly grass on intestinal microecological structure.

Active Publication Date: 2020-12-15
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, there has been no report on the regulating effect of jellygrass on the intestinal microecological structure

Method used

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  • Application of mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora
  • Application of mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora
  • Application of mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of ethanol extract of jelly jelly.

[0037] Pulverize the herbal jelly, reflux extraction with 50 times the amount of ethanol solution with a volume fraction of 50±10% for 30 minutes, repeat twice, filter, combine the filtrates, concentrate by rotary evaporation, and freeze-dry to obtain the jelly jelly extract. Prepare the required mass concentration with pure water before administration, and store at 4°C for later use.

Embodiment 2

[0039] A jellygrass granule, prepared by the following method: Weigh 80 g of the jelly jelly extract prepared in Example 1, 20 g of maltodextrin, spray an appropriate amount of ethanol to moisten the granules, dry the granules below 80°C, and then granulate the granules to obtain .

Embodiment 3

[0041] A kind of jelly jelly oral liquid, prepared by the following method: Weigh 20g jelly jelly extract prepared in Example 1, 50g glucose syrup, after dissolving with an appropriate amount of ethanol, add deionized water to 100mL, mix evenly, stand and filter After that, bottle it with 10mL per bottle.

[0042] The following is the content of the effect test example.

[0043] Experimental materials used in the following test examples: Rat, species: SD, grade: SPF grade, male, 180-220 g. The high-fat feed is SPF grade sterilized feed. The basic feed was sterilized feed, and the litter was provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. Drinking water is sterile distilled water. The rats had free access to water, the temperature of the feeding environment was controlled at 20-25°C, and the humidity was at 50-60°C. The day and night cycle was 12h:12h. All operations strictly complied with the relevant regulations and conf...

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Abstract

The invention provides application of a mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora and relates to the technical field of traditional Chinese medicines. According to the application, experiments prove that the mesona chinensis extract can be used for regulating an intestinal flora structure of a high-fat rat, promoting growth of beneficial bacteria, i.e., akkermansia muciniphila, improving a ratio of firmicutes / bacteroidetes, regulating the content of short-chain fatty acids, improving disorder of the intestinal florae, promoting metabolism of fats and inhibiting accumulation of the fats, thereby playing a role in reducing blood fat and protecting liver.

Description

technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to the application of Herba jellygrass extract in the preparation of medicines or health care products for regulating intestinal flora, especially in promoting the growth of intestinal probiotic Akkermansia, regulating and improving Firmicutes Phylum / Bacteroidetes ratio, increase intestinal short-chain fatty acid production, blood lipid-lowering drugs or applications in health food. Background technique [0002] With the improvement of living standards, people's lifestyles have undergone tremendous changes. Obesity and related metabolic diseases caused by improper lifestyle and unreasonable eating habits have become a major global public health problem that threatens individuals, families and even society. The incidence of hyperlipidemia in China is increasing year by year, and the damage to human health is mainly manifested in the damage to the cardiov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P1/00A61P3/06
CPCA61K36/53A61P1/00A61P3/06
Inventor 严萍詹若挺宋晓娟卢晓莹林翠清曾唯雅罗桂花肖鸬华
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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